<i>In vitro</i> fertilization treatment influences glucose tolerance in multiple pregnancy

Jones, Ben; Zöllner, Julia; Haynes, Sarah C.; Cheng, Feng; Dornhorst, Anne

doi:10.1111/j.1464-5491.2012.03761.x

Cited by 10 publications

(7 citation statements)

References 7 publications

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“…6,12 In particular, women requiring ART tend to be much older than women with SC. 6,12 Therefore, in an attempt to get rid of such a powerful interfering factor, we have paid much attention to select and match women with age. Also, we have included only singleton pregnancies as twin pregnancy, occurring more frequently in women with ART conception, could represent a greater and independent risk for GDM.…”

Section: Discussionmentioning

confidence: 99%

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Assisted reproductive technology, risk of gestational diabetes, and perinatal outcomes in singleton pregnancies

Bianchi

Brocchi

Baronti

et al. 2023

Diabetes Metabolism Res

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Aims To evaluate the impact of assisted reproductive technology (ART) on the risk of gestational diabetes mellitus (GDM) in single pregnancies. Materials and Methods We retrospectively collected clinical and anthropometric data of 219ART‐ and 256 age‐ and body mass index (BMI)‐matched women with spontaneous conception screened for GDM. The primary outcome was to evaluate GDM prevalence in ART women. Results There were no differences in age, BMI, and family history of diabetes in the two groups of women. ART‐women were more frequently primiparous, whereas the prevalence of previous GDM was higher in SC‐women. The prevalence of GDM in the whole cohort was 36.1% and was higher in ART‐women (52.3% vs. 23.4%; p < 0.0001). In the whole cohort, on multivariate analysis, family history of diabetes (OR 1.67; 95% CI: 1.03–2.69), previous GDM (OR 7.05; 95% CI: 2.92–17.04), pre‐pregnancy obesity (OR 2.72; 95% CI 1.21–6.13), and ART (OR 4.14; 95% CI 2.65–6.48) were independent risk factors for GDM. Among ART‐women, age over 40 years was associated with GDM. Preterm delivery was more common in ART‐women; gestational week at delivery, birth weight, ponderal index, and Apgar score were lower in ART‐women than in SC‐women, both in the whole cohort and in GDM women. Conclusions Among women undergoing ART treatment, at least one in two develops GDM. ART appears to be an independent risk factor for GDM in single pregnancies, particularly above the age of 40. ART treatment seems to be associated with an increased rate of preterm delivery and lower neonatal birth weight and Apgar score, especially in GDM women. Clinical Trial Registration The study was not registered as it is an observational retrospective evaluation.

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Section: Discussionmentioning

confidence: 99%

“…A higher incidence of GDM after ART might be due to multiple factors such as age, obesity, Polycystic ovary syndrome and multiple pregnancy, all conditions commonly occurring in women requiring ART 6,12 . In particular, women requiring ART tend to be much older than women with SC 6,12 .…”

Section: Discussionmentioning

confidence: 99%

Assisted reproductive technology, risk of gestational diabetes, and perinatal outcomes in singleton pregnancies

Bianchi

Brocchi

Baronti

et al. 2023

Diabetes Metabolism Res

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“…Women with PCOS had higher BMI than controls in both studies [11,48], but the increased risk for GDM in PCOS persisted after correcting for BMI. However, women with PCOS (28, 22) had required fertility treatment, which suggests a more severe PCOS phenotype and in vitro fertilization as well as assisted reproduction are associated with an increased risk of GDM [62]. Women with PCOS tended to be older than controls in the study by Mikola et al [11] (30.4 vs. 29.5 years, p=0.05), which could also have increased GDM risk [22].…”

Section: Pcosmentioning

confidence: 99%

Polycystic ovary syndrome and hyperglycaemia in pregnancy. A narrative review and results from a prospective Danish cohort study

Palm

Glintborg

Kyhl

et al. 2018

Diabetes Research and Clinical Practice

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“…No está de todo claro si los embarazos únicos con FIV tienen un mayor riesgo de DG en comparación con los embarazos únicos espontáneos. Estudios previos han informado una alta prevalencia de DG (11 % -43 %) en mujeres con FIV (14,32,33). En este estudio se encontró una diferencia significativa a favor del grupo de EMA y FIV (16,7 % vs. 5,9 %).…”

Section: Discussionunclassified

Influencia de la fecundación in vitro en los resultados maternos y neonatales en mujeres con edad materna avanzada

Karin¹,

Álvarez-Silvares²,

Bermúdez-González³

2022

RSOGV

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Objetivo: Establecer el efecto de la fecundación in vitro en la frecuencia de complicaciones maternoneonatales en gestantes con edad mayor o igual de 40 años. Métodos: Casos y controles anidados en cohorte, con recogida de datos retrospectiva y seguimiento prospectivo. Cohorte total de 207 gestantes. Casos o subcohorte con fecundación in vitro y grupo control con gestación espontánea. Se realizaron pruebas paramétricas y no paramétricas para determinar la asociación potencial entre las variables. Resultados: Las mujeres que lograron su gestación mediante fecundación in vitro tuvieron una edad media mayor (p = 0,03). En los casos fue más frecuente la primiparidad (44,4 % vs. 22,2 %, p = 0,02), la tasa de diabetes gestacional RR = 2,83 (IC95 %: 1,19-6,77; p = 0,023) y la tasa de cesáreas (p = 0,05). En las gestaciones espontáneas se observó mayor frecuencia de inicio de trabajo de parto espontáneo (56,86 % vs. 37,03 %, p = 0,019). No se encontraron diferencias en la prevalencia de diabetes pregestacional, estados hipertensivos del embarazo, prematuridad, restricción de crecimiento intrauterino, macrosomía fetal, test de Apgar, pH patológico, ingresos neonatales y hemorragia posparto. La tasa de mortalidad perinatal fue mayor en el grupo con gestación lograda mediante fecundación in vitro. Conclusión: La concepción por fecundación in vitro en una población gestante con edad materna avanzada confiere un riesgo añadido a la misma en los resultados adversos maternos y neonatales. Palabras clave: Embarazo; Edad materna; Morbilidad; Resultado del embarazo; Técnicas reproductivas; Fertilización in vitro.

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In vitro fertilization treatment influences glucose tolerance in multiple pregnancy

Cited by 10 publications

References 7 publications

Assisted reproductive technology, risk of gestational diabetes, and perinatal outcomes in singleton pregnancies

Assisted reproductive technology, risk of gestational diabetes, and perinatal outcomes in singleton pregnancies

Polycystic ovary syndrome and hyperglycaemia in pregnancy. A narrative review and results from a prospective Danish cohort study

Influencia de la fecundación in vitro en los resultados maternos y neonatales en mujeres con edad materna avanzada

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