<i>In Vitro</i> Exposure of Wounded Diabetic Fibroblast Cells to a Helium-Neon Laser at 5 and 16 J/cm<sup>2</sup>

Houreld, Nicolette Nadene; Abrahamse, Heidi

doi:10.1089/pho.2006.990

Cited by 71 publications

(28 citation statements)

References 15 publications

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“…23 It is described as ranging from 4 to 10 J/cm 2 for soft tissues. [35][36][37][38][39] In light of this information, the laser doses selected were 10 and 20 J/cm 2 in this investigation. Although some researchers reported that there is no relationship between the cortical bone thickness and the stability of the mini screw, [40][41][42] others reported an opposing argument.…”

Section: Discussionmentioning

confidence: 99%

Histomorphometric Evaluation of the Effects of Various Diode Lasers and Force Levels on Orthodontic Mini Screw Stability

Göymen

İşman

Taner

et al. 2015

Photomedicine and Laser Surgery

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Objective: The purpose of this study was to evaluate the effects of different laser dose and force levels on the stability of orthodontic mini screws used for anchorage, by histomorphometric analyses. Background data: Low-level laser therapy speeds up blood flow, improves the mechanism of the revitalization processes, reduces the risk of infection, boosts metabolic activities, and accelerates the healing of the damaged tissue. Although there are many research studies about low-level laser therapy applications in a variety of areas, no investigations were found concerning mini screw stability using various laser dose levels with different force level applications. Methods: Seventeen New Zealand white rabbits were used. A total of 68 cylindrical, self-drilling orthodontic mini screws were threaded at the fibula. Experimental subjects were divided into six groups; force application was not performed in the first three groups, whereas 150g of force was applied via nickel-titanium closed-coil springs placed between two mini screws in the other three groups. Measurements of the initial torque values (10 Ncm) were manipulated by a digital portable torque gauge. Various low-level laser doses were applied to the groups during the postoperative 10 days. After 4 weeks, bone-to-implant contact and cortical bone thickness were histomorphometrically analyzed. Results: In the 150g force plus 20 J/cm 2 dosage group, the highest bone-to-implant contact values were observed. ( p < 0.05) There were no statistically significant correlations between cortical bone thickness and bone-to-implant contact values; on the other hand, no significant difference was found among the same groups in terms of cortical bone thickness values ( p > 0.05). Conclusions: Low-level laser therapy was noticed to induce the mini screw-bone contact area. Low-level laser therapy may be a supplementary treatment method to increase the stability of the orthodontic mini screw.

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Section: Discussionmentioning

confidence: 99%

Histomorphometric Evaluation of the Effects of Various Diode Lasers and Force Levels on Orthodontic Mini Screw Stability

Göymen

İşman

Taner

et al. 2015

Photomedicine and Laser Surgery

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“…This finding is similar to literature data indicating that adjuvant LLLT therapy reduces gingival inflammation during periodontal treatment and gives better results than basic periodontal treatment alone. 15,[35][36][37][38][39][40][41] On the side of jaws subjected to combined therapy there was no difference in nuclear area between groups, suggesting that when LLLT and basic periodontal therapy are combined, patients with DM can achieve gingival health similar to that in persons without diabetes.…”

Section: Discussionmentioning

confidence: 99%

Low-Level Lasers as an Adjunct in Periodontal Therapy in Patients with Diabetes Mellitus

Obradoviç

Kesić²,

Mihailović³

et al. 2012

Diabetes Technology & Therapeutics

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Background: Diabetes mellitus (DM) increases the risk of periodontitis, and severe periodontitis often coexists with severe DM. The proposed dual pathway of tissue destruction suggests that control of chronic periodontal infection and gingival inflammation is essential for achieving long-term control of DM. The purpose this study is to evaluate the effects of low-level laser therapy (LLLT) by exfoliative cytology in patients with DM and gingival inflammation. Subjects and Methods: Three hundred patients were divided in three equal groups: Group 1 consisted of patients with periodontitis and type 1 DM, Group 2 of patients with periodontitis and type 2 DM, and Group 3 of patients with periodontitis (control group). After oral examination, smears were taken from gingival tissue, and afterward all of the patients received oral hygiene instructions, removal of dental plaque, and full-mouth scaling and root planing. A split-mouth design was applied; on the right side of jaws GaAlAs LLLT (670 nm, 5 mW, 14 min/day) (model Mils 94; Optica Laser, Sofia, Bulgaria) was applied for five consecutive days. After the therapy was completed, smears from both sides of jaws were taken. The morphometric analysis was done using the National Institutes of Health Image software program and a model NU2 microscope (Carl Zeiss, Jena, Germany). Results: Investigated parameters were significantly lower after therapy compared with values before therapy. After therapy on the side subjected to LLLT, there was no significantly difference between patients with DM and the control group. Conclusions: It can be concluded that LLLT as an adjunct in periodontal therapy reduces gingival inflammation in patients with DM and periodontitis.

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“…The alkaline comet assay indicated that 685 nm PBM delivered at energy densities above 10 J/cm 2 caused DNA damage (both SSBs and DSBs) more than 2-fold in comparison with background control levels. Previously, Houreld et al (2007) reported that after 30 minutes, a single exposure of 632.8 nm PBM at 5 J/cm 2 caused a significant increase in DNA damage [39]. However, it is not clear whether this DNA damage is completely repairable.…”

Section: Discussionmentioning

confidence: 99%

Photobiomodulation leads to enhanced radiosensitivity through induction of apoptosis and autophagy in human cervical cancer cells

Djavid

Bigdeli

Goliaei

et al. 2017

Journal of Biophotonics

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The radiomodulatory effect of photobiomodulation (PBM) has recently been studied in cancer cells. The aim of this study was to investigate cellular mechanisms involved in the X-ray radiosensitivity of HeLa cells pre-exposed to PBM. HeLa cells were irradiated with 685 nm laser at different energy densities prior to X-ray ionizing radiation. After irradiation, clonogenic cell survival, cell death due to apoptosis and autophagy were determined. Levels of intracellular reactive oxygen species (ROS), DNA damage and, cell cycle distribution after PBM were measured. PBM at different energy densities (5–20 J/cm2) was not cytotoxic. However, HeLa cells pre-exposed to 20 J/cm2 showed enhanced inhibition of colony formation following ionizing radiation. Enhanced radiosensitivity was due to increased oxidative stress, DNA damage, and radiation-induced apoptosis and autophagy. These results suggest that 685 nm PBM at a higher energy density could possibly be a promising radiosensitizing agent in cervical cancer, to decrease the radiation dose delivered, and therefore prevent the side-effects that are associated with cancer radiotherapy

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In Vitro Exposure of Wounded Diabetic Fibroblast Cells to a Helium-Neon Laser at 5 and 16 J/cm²

Cited by 71 publications

References 15 publications

Histomorphometric Evaluation of the Effects of Various Diode Lasers and Force Levels on Orthodontic Mini Screw Stability

Histomorphometric Evaluation of the Effects of Various Diode Lasers and Force Levels on Orthodontic Mini Screw Stability

Low-Level Lasers as an Adjunct in Periodontal Therapy in Patients with Diabetes Mellitus

Photobiomodulation leads to enhanced radiosensitivity through induction of apoptosis and autophagy in human cervical cancer cells

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In Vitro Exposure of Wounded Diabetic Fibroblast Cells to a Helium-Neon Laser at 5 and 16 J/cm2

Cited by 71 publications

References 15 publications

Histomorphometric Evaluation of the Effects of Various Diode Lasers and Force Levels on Orthodontic Mini Screw Stability

Histomorphometric Evaluation of the Effects of Various Diode Lasers and Force Levels on Orthodontic Mini Screw Stability

Low-Level Lasers as an Adjunct in Periodontal Therapy in Patients with Diabetes Mellitus

Photobiomodulation leads to enhanced radiosensitivity through induction of apoptosis and autophagy in human cervical cancer cells

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In Vitro Exposure of Wounded Diabetic Fibroblast Cells to a Helium-Neon Laser at 5 and 16 J/cm²