<i>In vitro</i>
            evaluation of cytotoxic potential of essential oil extracted from leaves of
            <i>Croton heliotropiifolius</i>
            Kunth in human tumor cells

Cavalcanti, Bruno Coêlho; Magalhães, Islay Lima; Rocha, Danilo Damasceno; Stefânio Barreto, Francisco; de Andrade Neto, João Batista; Magalhães, Hemerson Iury Ferreira; dos Santos, Cláudio Costa; de Moraes, Manoel Odorico

doi:10.1080/15287394.2023.2276894

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…Cinnamomum cassia essential oil showed anti-oral cancer activity in HSC-3 cells, through a significant increase in ROS production [54]. The cytotoxic potential of Croton heliotropiifolius on different human cancer cell lines, namely leukaemia, colon, melanoma and glioblastoma, was also related to oxidative stress, culminating in mitochondrial respiratory dysfunction and DNA damage, triggering cell death via apoptosis [55]. In the context of cancer, some monoterpenes like carvacrol [56] and hinokitiol (synonym of β-thujaplicin) [57] are also able to potentiate mitochondrial dysfunction.…”

Section: Antagonistic Hallmarks Mitochondrial Dysfunctionmentioning

confidence: 99%

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

Zuzarte,

Sousa,

Alves-Silva

et al. 2024

Biomedicines

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Ageing is a natural process characterized by a time-dependent decline of physiological integrity that compromises functionality and inevitably leads to death. This decline is also quite relevant in major human pathologies, being a primary risk factor in neurodegenerative diseases, metabolic disorders, cardiovascular diseases and musculoskeletal disorders. Bearing this in mind, it is not surprising that research aiming at improving human health during this process has burst in the last decades. Importantly, major hallmarks of the ageing process and phenotype have been identified, this knowledge being quite relevant for future studies towards the identification of putative pharmaceutical targets, enabling the development of preventive/therapeutic strategies to improve health and longevity. In this context, aromatic plants have emerged as a source of potential bioactive volatile molecules, mainly monoterpenes, with many studies referring to their anti-ageing potential. Nevertheless, an integrated review on the current knowledge is lacking, with several research approaches studying isolated ageing hallmarks or referring to an overall anti-ageing effect, without depicting possible mechanisms of action. Herein, we aim to provide an updated systematization of the bioactive potential of volatile monoterpenes on recently proposed ageing hallmarks, and highlight the main mechanisms of action already identified, as well as possible chemical entity–activity relations. By gathering and categorizing the available scattered information, we also aim to identify important research gaps that could help pave the way for future research in the field.

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