<i>In vitro</i>effects of rosmarinic acid on glutathione reductase and glucose 6-phosphate dehydrogenase

Tandogan, Berivan; Kuruüzüm-Uz, Ayşe; Sengezer, C; Güvenalp, Zühal; Lö, Demirezer; Ulusu, Nuriye Nuray

doi:10.3109/13880209.2010.533187

Cited by 27 publications

(19 citation statements)

References 27 publications

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“…Different plant genera are an important source of rosmarinic acid (28). Inhibition of glutathione reductase and glucose 6-phosphate dehydrogenase antioxidant enzymes by rosmarinic acid was shown in our previous study (29). Thus, the antioxidant and AChE inhibitory effects of rosmarinic acid were found to be significant with in vitro and ex vivo methods.…”

Section: Discussionmentioning

confidence: 86%

Molecular docking and ex vivo and in vitro anticholinesterase activity studies ofSalvia sp. and highlighted rosmarinic acid

Demirezer¹,

Gürbüz²,

Uğur³

et al. 2015

Turk J Med Sci

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Background/aim: To evaluate acetylcholinesterase (AChE) inhibitory activity and antioxidant capacity of the major molecule from Salvia sp., rosmarinic acid, as a drug candidate molecule for treatment of Alzheimer disease (AD). Materials and methods:The AChE inhibitory activity of different extracts from Salvia trichoclada, Salvia verticillata, and Salvia fruticosa was determined by the Ellman and isolated guinea pig ileum methods, and the antioxidant capacity was determined with DPPH. The AChE inhibitory activity of the major molecule rosmarinic acid was determined by in silico docking and isolated guinea pig ileum methods. Results:The methanol extract of Salvia trichoclada showed the highest inhibition on AChE. The same extract and rosmarinic acid showed significant contraction responses on isolated guinea pig ileum. All the extracts and rosmarinic acid showed high radical scavenging capacities. Docking results of rosmarinic acid showed high affinity to the selected target, AChE. Conclusion:In this study in vitro and ex vivo studies and in silico docking research of rosmarinic acid were used simultaneously for the first time. Rosmarinic acid showed promising results in all the methods tested.

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Section: Discussionmentioning

confidence: 86%

Molecular docking and ex vivo and in vitro anticholinesterase activity studies ofSalvia sp. and highlighted rosmarinic acid

Demirezer¹,

Gürbüz²,

Uğur³

et al. 2015

Turk J Med Sci

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“…Because both classes have disadvantages (e.g., neurotoxicity for 6-AN and a lack of specificity for androsterone derivatives), new inhibitors of both groups are under evaluation to obtain pharmacological agents that modulate G6PD activity with tissue-specific and enzyme-specific targeting [31]. Among natural products, catechin gallates [32] and rosmarinic acid [33] have been recently discovered as inhibitors of G6PD and may represent the next generation of PPP inhibitors.…”

Section: The Oxidative Branch Of the Ppp And Its Regulation In Mammalmentioning

confidence: 99%

The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate

Riganti

Gazzano

Polimeni

et al. 2012

Free Radical Biology and Medicine

344

289

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“…Of the tested compounds, CB83 showed a significant inhibition on the viability of the mammary carcinoma cell line MCF10-AT1 (119). Some natural products, such as gallated catechins or rosmarinic acid, have been also proposed as G6PD inhibitors (120, 121). With regard to the non-specific inhibitors, it has been reported that treatment with Imatinib (Gleevec), a tyrosine kinase inhibitor designed to specifically target the BCR-ABL oncogene protein, was able to decrease the activity of both hexokinase and G6PD in leukemia cells, leading to suppression of aerobic glycolysis (122, 123).…”

Section: Targeting G6pd In Cancermentioning

confidence: 99%

Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma

2017

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In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined. The pentose phosphate pathway (PPP) is one of the fundamental components of cellular metabolism crucial for cancer cells. This review will discuss recent findings regarding the involvement of PPP enzymes in several types of cancer, with a focus on hepatocellular carcinoma (HCC). We will pay considerable attention to the involvement of glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of the PPP. Subsequently, we discuss the inhibition of the PPP as a potential therapeutic strategy against cancer, in particular, HCC.

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In vitroeffects of rosmarinic acid on glutathione reductase and glucose 6-phosphate dehydrogenase

Cited by 27 publications

References 27 publications

Molecular docking and ex vivo and in vitro anticholinesterase activity studies ofSalvia sp. and highlighted rosmarinic acid

Molecular docking and ex vivo and in vitro anticholinesterase activity studies ofSalvia sp. and highlighted rosmarinic acid

The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate

Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma

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