<i>In vitro</i>effects of hydrochloric and lactic acids on bioelectric properties of equine gastric squamous mucosa

Andrews, Frank M.; Buchanan, Benjamin R.; Elliott, Sarah B.; Jassim, Rafat Al; McGowan, Catherine; Saxton, Arnold M.

doi:10.2746/042516408x293565

Cited by 27 publications

(20 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The fasting time and type and feeding scheme may have influenced these results. In vitro studies have demonstrated that VFA has minimal ulcerogenic capacity in the non-glandular mucosa of the horse (21). The effect of lactic acid is dependent on the amount and time of exposure to the mucosa; therefore, it is possible to infer that this VFA plays a poor role in the generation of gastric ulcers in the horses of this study.…”

Section: Discussionmentioning

confidence: 83%

“…This results in different levels of change in the cell membrane permeability, according to the type of acid (5,6,21). Acetic acid showed the highest concentration (59%) in the gastric contents of the horses of this study.…”

Section: Discussionmentioning

confidence: 96%

“…Los AGV modifican las propiedades bioeléctricas de la mucosa al disminuir el transporte de sodio, lo que ocasiona diferentes niveles de alteración en la permeabilidad según el tipo de ácido (5,6,21). El ácido acético presentó la mayor concentración (59%) en el contenido gástrico, dato similar a otros estudios (5, 6, 7), y menor que 85% determinado en caballos tratados también con aceite de maíz y de arroz (13).…”

Section: Discussionunclassified

“…En contraste, las concentraciones del ácido láctico halladas fueron mínimas a las reportadas, tal vez el período de ayuno y el tipo y esquema de alimentación influyeron en estos resultados. El poder ulcerogénico también es mínimo en la mucosa no glandular según estudios "in vitro" (21), siendo su efecto relacionado con la cantidad y el tiempo de exposición a la mucosa; por consiguiente, se puede inferir una baja participación en la presencia de las úlceras en este trabajo.…”

Section: Discussionunclassified

See 3 more Smart Citations

Efecto del aceite de maíz sobre los ácidos grasos volátiles en caballos con úlceras gástricas inducidas

Carmona

2016

Rev MVZ Córdoba

View full text Add to dashboard Cite

Objetive. To determine the influence of corn oil on the volatile fatty acids (VFA) concentrations in the gastric juice in horses with phenylbutazone (PBZ) induced gastric ulcers and Correlate the gastroscopic findings with the VFA concentrations. Materials and methods. 15 horses were allotted in 3 groups. Group I (control) received placebo during first 6 days (induction period) and was treated with sucralfate for 2 weeks (treatment period). Groups II and III received PBZ during the induction phase. After 6 days, horses from group II received 70 mL of corn oil /100 kg of body weight/ po, twice a day, for 2 weeks and horses from group III received 90 mL of corn oil/100 kg of body weight/ po, twice a day, for 2 weeks. All horses were examined by gastroscopy at days 0, 7 and 21. The lesions were recorded and classified according to the number and severity. Samples from gastric fluid were taken to measure the concentrations of the acetic, propionic, butyric and lactic acids. Results. Both PBZ protocols produced lesions in the both non-glandular and glandular areas of the stomach. All the treatments produced healing of the injured mucosa glandular. Neither of the two corn oil treatments affected healing of the gastric ulcers located in the non-glandular area. Conclusions. The concentrations of acetic and butyric acids were highest in the gastric juice. The corn oil and sucralfate did not lead to differences in the concentration of acetic acid and butyric acid.Keywords: Equine, stomach, gastric juices, endoscopy, sucralfate (Sources: CAB, DeCs). RESUMENObjetivo. Determinar el efecto del aceite de maíz sobre la concentración de los ácidos grasos volátiles (AGV) en el jugo gástrico de caballos con úlceras gástricas inducidas con fenilbutazona (FBZ) y correlacionar los hallazgos gastroscópicos con las concentraciones de AGV. Materiales y métodos. 15 caballos fueron asignados en 3 grupos. El grupo I (control) recibió placebo durante los primeros 6 días (período de inducción) y fue tratado con sucralfato durante 2 semanas (período de tratamiento). Los grupos II y III recibieron FBZ en la fase de inducción. Después de 6 días, los caballos del grupo II recibieron 70 ml de aceite de maíz /100 kg de peso corporal / vo, dos veces al día, durante 2 semanas Effects of corn oil on the volatile fatty acids in horses with induced gastric ulcers Efecto del aceite de maíz sobre los ácidos grasos volátiles en caballos con úlceras gástricas inducidas

show abstract

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 96%

Section: Discussionunclassified

See 2 more Smart Citations

Efecto del aceite de maíz sobre los ácidos grasos volátiles en caballos con úlceras gástricas inducidas

Carmona

2016

Rev MVZ Córdoba

View full text Add to dashboard Cite

show abstract

“…Such risk factors may lead to an imbalance in aggressive factors within the stomach such as hydrochloric acid, pepsin, volatile fatty acids and bile acids, and those factors protecting against gastric ulceration such as mucus and bicarbonate (Andrews et al, 2008). Gastric ulcers in the squamous mucosa may be directly related to Burden, Gallagher, Thiemann and Trawford the amount of exposure to gastric acidity whereas ulceration in the glandular area of the stomach is more likely to be due to decreased blood flow, bicarbonate and mucus secretion.…”

Section: Discussionmentioning

confidence: 99%

Necropsy survey of gastric ulcers in a population of aged donkeys: prevalence, lesion description and risk factors

Burden¹,

Gallagher²,

Thiemann³

et al. 2009

Animal

View full text Add to dashboard Cite

There is no information about the prevalence of gastric ulceration in donkeys or potential risk factors for its presence in donkeys. The donkey is a stoic, hardy animal that has not previously been thought to suffer from this disease. However, gastric ulceration was found to be a problem in a population of non-working UK donkeys resident at the Donkey Sanctuary and its prevalence was estimated by examining necropsy data over a 2-year period during 2005 to 2006. Associations with clinical and management factors were determined. In total, 426 donkeys were examined at necropsy to determine the presence of gastric ulceration. Lesions were described and scored according to a four-point scale. Management and clinical data from these donkeys were analysed to identify potential risk factors for the presence of gastric ulceration. Terminal blood samples were also studied to determine whether animals were exhibiting hyperlipaemia prior to death. Results showed that 41% (n 5 174) of the donkeys studied had evidence of gastric ulceration at necropsy. Most (49%) of the ulcers were of a medium size (area of >2 cm 2 -,10 cm 2 ) and the most common site for ulcers was the margo plicatus. Of the donkeys examined, 18% had hyperlipaemia prior to or death or euthanasia and this was a risk factor for donkeys developing gastric ulceration; 62% of hyperlipaemia cases also displayed gastric ulceration ( P , 0.001). Kidney disease was a potential risk factor ( P 5 0.02), with 74% of these animals having gastric ulceration. Donkeys that died or were euthanased due to respiratory disease were at a decreased risk of developing ulceration ( P 5 0.01) Donkeys fed a carbohydrate-based diet were more likely ( P , 0.001) to have gastric ulceration than those fed a fibre-only diet, with 55% having gastric ulceration compared with 33% in the fibre-only group. This study has shown that gastric ulceration is commonly observed in donkeys at necropsy and may be extensive.

show abstract

Good Feeding: Nutrition and Feeding of the Arabian Camel (Camelus dromedarius)

Al Jassim

2024

Animal Welfare

View full text Add to dashboard Cite

In vitroeffects of hydrochloric and lactic acids on bioelectric properties of equine gastric squamous mucosa

Abstract: HCl induced alteration in bioelectric properties of equine NG mucosa whereas addition of LRS did not, other than those changes seen with HCl alone.

Cited by 27 publications

References 21 publications

Efecto del aceite de maíz sobre los ácidos grasos volátiles en caballos con úlceras gástricas inducidas

Efecto del aceite de maíz sobre los ácidos grasos volátiles en caballos con úlceras gástricas inducidas

Necropsy survey of gastric ulcers in a population of aged donkeys: prevalence, lesion description and risk factors

Good Feeding: Nutrition and Feeding of the Arabian Camel (Camelus dromedarius)

Contact Info

Product

Resources

About