<i>In vitro</i>effects of cisapride, metoclopramide and bethanechol on smooth muscle preparations from abomasal antrum and duodenum of dairy cows

Michel, A; Mevissen, Meike; Burkhardt, H.; Steiner, Adrian

doi:10.1046/j.0140-7783.2003.00528.x

Cited by 12 publications

(17 citation statements)

References 22 publications

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“…Inhibition of abomasal motility may be major reason of DA. The prerequisite for DA is abomasal atony due to the accumulation of gas and fluid in the abomasum Michel et al 2003, Wittek et al 2008, Buehler et al 2008, Doll et al 2009. Displaced abomasa usually contain more methane (up to 70%) which is comparable to the rumen (Sarashina et al 1990, Doll et al 2009.…”

Section: Etiology and Risk Factorsmentioning

confidence: 99%

Metabolic indicators and risk factors of left displaced abomasum in dairy cattle

Şen¹,

Wittek²,

Güzelbekteş³

2015

EurasianJVetSci

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Section: Etiology and Risk Factorsmentioning

confidence: 99%

Metabolic indicators and risk factors of left displaced abomasum in dairy cattle

Şen¹,

Wittek²,

Güzelbekteş³

2015

EurasianJVetSci

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“…Cisapride was investigated because it increases the rate of gastrointestinal motility in the cat, dog, and horse 20. Bethanechol was investigated because of reports documenting its accelerating effect on gastric and abomasal motility 21, 22, 23, 24…”

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confidence: 99%

Effect of Orally Administered Cisapride, Bethanechol, and Erythromycin on the Apparent Efficiency of Colostral IgG Absorption in Neonatal Holstein‐Friesian Calves

Ghoreishi

Nouri

Rasooli

et al. 2015

Veterinary Internal Medicne

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ObjectiveTo evaluate the effect of orally administered cisapride, bethanechol, and erythromycin on the absorption of colostral IgG in dairy calves.AnimalsTwenty‐four healthy neonatal Holstein‐Friesian calves.ProceduresCalves were randomly assigned to one of the following treatments: 0.9% NaCl solution (2 mL, PO; negative control); erythromycin lactobionate (20 mg/kg BW, PO; anticipated to be a positive control); cisapride (0.5 mg/kg BW, PO); bethanechol chloride (0.5 mg/kg BW, PO). Calves were fed 3 L of pooled bovine colostrum containing acetaminophen (50 mg/kg) by suckling and oroesophageal intubation 30 minutes after each treatment was administered. Jugular venous blood samples were obtained periodically after the start of feeding and plasma total IgG, protein, acetaminophen, and glucose concentrations determined. Abomasal emptying rate was assessed by the time to maximal plasma acetaminophen concentration.ResultsOral administration of cisapride facilitated the absorption of colostral IgG and protein. The effect of cisapride on abomasal emptying rate could not be evaluated because cisapride appeared to interfere with acetaminophen metabolism. Based on the total IgG and total protein concentration‐time relationships, the beneficial effects of cisapride appeared to occur early after oral administration and were transient.Conclusions and Clinical ImportanceAdditional studies appear indicated to characterize the effect of cisapride dose on the magnitude and duration of its effect on facilitating the absorption of colostral IgG and protein. Identification of a nonantimicrobial method for increasing abomasal emptying rate, such as cisapride, will potentially provide a practical and effective method for facilitating transfer of passive immunity in colostrum‐fed dairy calves.

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“…30 In healthy horses, bethanechol stimulates gastric emptying 32 and myoelectric activity of the ileum, cecum, and right ventral colon. 33 In vitro, bethanechol induces a significant concentration-dependent increase in contractility traits in preparations of smooth muscle obtained from the esophageal groove of calves 34 as well as the abomasal antrum 35 and proximal portion of the colon of healthy cows. 36 In contrast, no contractile effect of bethanechol was observed in preparations of smooth muscle obtained from the proximal portion of the duodenum.…”

mentioning

confidence: 99%

“…36 In contrast, no contractile effect of bethanechol was observed in preparations of smooth muscle obtained from the proximal portion of the duodenum. 35 In vivo, bethanechol increases the myoelectric activity of the ileocecocolic area of healthy cows 37 and the abomasum and duodenum of healthy yearling cattle. 27 Bethanechol (0.07 mg/kg, SC, q 8 h for 2 days) also reportedly can be used successfully for conservative treatment of cows with spontaneous cecal dilatation.…”

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confidence: 99%

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In vitro effects of bethanechol on specimens of intestinal smooth muscle obtained from the duodenum and jejunum of healthy dairy cows

Pfeiffer

Mevissen²,

Steiner³

et al. 2007

ajvr

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Objective-To describe the in vitro effects of bethanechol on contractility of smooth muscle preparations from the small intestines of healthy cows and define the muscarinic receptor subtypes involved in mediating contraction.Sample Population-Tissue samples from the duodenum and jejunum collected immediately after slaughter of 40 healthy cows.Procedures-Cumulative concentration-response curves were determined for the muscarinic receptor agonist bethanechol with or without prior incubation with subtype-specific receptor antagonists in an organ bath. Effects of bethanechol and antagonists and the influence of intestinal location on basal tone, maximal amplitude (A max ), and area under the curve (AUC) were evaluated.Results-Bethanechol induced a significant, concentration-dependent increase in all preparations and variables. The effect of bethanechol was more pronounced in jejunal than in duodenal samples and in circular than in longitudinal preparations. Significant inhibition of the effects of bethanechol was observed after prior incubation with muscarinic receptor subtype M 3 antagonists (more commonly for basal tone than for A max and AUC). The M 2 receptor antagonists partly inhibited the response to bethanechol, especially for basal tone. The M 3 receptor antagonists were generally more potent than the M 2 receptor antagonists. In a protection experiment, an M 3 receptor antagonist was less potent than when used in combination with an M 2 receptor antagonist. Receptor antagonists for M 1 and M 4 did not affect contractility variables. Conclusions and ClinicalRelevance-Bethanechol acting on muscarinic receptor subtypes M 2 and M 3 may be of clinical use as a prokinetic drug for motility disorders of the duodenum and jejunum in dairy cows.The important role of the parasympathetic nervous system in physiologic processes of GI tract motility and in the pathophysiology of motility disorders has been described for various species. [1][2][3][4][5][6][7] In the cholinergic system, acetylcholine activates G-protein-coupled muscarinic receptors to cause smooth muscle contraction in several organs. 1,2 Five mAChR subtypes (M 1 to M 5 , respectively) have been cloned 8 and defined pharmacologically. 3,9 Address correspondence to Dr. Meylan.. NIH Public Access Author ManuscriptAm J Vet Res. Author manuscript; available in PMC 2009 September 7.Published in final edited form as: Am J Vet Res. 2007 March ; 68(3): 313-322. doi:10.2460/ajvr.68.3.313. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptThe M 2 and M 3 mAChR subtypes are the predominant receptors in the GI tract of several species, with a ratio for M 2 :M 3 of approximately 4:1. 1,10 However, the M 3 receptor subtype is considered to be of predominant importance in eliciting muscle contractions, and the exact role of the more abundant M 2 subtype remains unclear. 10,11 A study 12 in M 3 receptor knockout mice has emphasized the role of M 3 mAChRs for smooth muscle contraction because ileal contractile response to carbachol in vi...

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In vitroeffects of cisapride, metoclopramide and bethanechol on smooth muscle preparations from abomasal antrum and duodenum of dairy cows

Cited by 12 publications

References 22 publications

Metabolic indicators and risk factors of left displaced abomasum in dairy cattle

Metabolic indicators and risk factors of left displaced abomasum in dairy cattle

Effect of Orally Administered Cisapride, Bethanechol, and Erythromycin on the Apparent Efficiency of Colostral IgG Absorption in Neonatal Holstein‐Friesian Calves

In vitro effects of bethanechol on specimens of intestinal smooth muscle obtained from the duodenum and jejunum of healthy dairy cows

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