<i>In Vitro </i>Effect of Dipyrone on Several Peroxidase Labelled Immunoassays

Gascón-Roche, Neus; Mora-Brugués, Josefina; Rodrı́guez-Espinosa, José; Cortés-Rius, M; González‐Sastre, Francesc

doi:10.1515/cclm.1995.33.4.221

Cited by 1 publication

(1 citation statement)

References 3 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 Gascon-Roche and collaborators described a significant positive interference in the determination of free triiodothyronine (T3), cortisol, estradiol and a negative interference in the carcinoembryonic antigen, human chorionic gonadotropin and α-fetoprotein, when determined by an immunoenzymatic assay based in the luminescence that uses peroxidase as a marker. 27…”

Section: Discussionmentioning

confidence: 99%

Drug dosing using estimated glomerular filtration rate: Misclassification due to metamizole interference in a creatinine assay

et al. 2021

View full text Add to dashboard Cite

The estimated glomerular filtration rate is a rather important measurement for patients under intensive care, since they often receive several drugs, and impaired renal function may result in misleading dosing. The estimated glomerular filtration is derived from mathematical models using serum creatinine, a measurement that suffers interference of some drugs, such as metamizole. The study intented to evaluate the impact on patient stratification for dose adjustment of two antimicrobials (meropenem and vancomycin) caused by metamizole interference in creatinine measurement by dry chemistry. A cross-sectional study was conducted with a group of 108 hospitalized patients under metamizole prescriptions at fixed intervals. Serum creatinine levels were determined by enzymatic dry chemistry and JaffÃ© assays and the estimated glomerular filtration rate was calculated through the CKD-EPI equation. Patients were stratified in groups according to their estimated glomerular filtration rate for drug dosing of vancomycin and meropenem. As expected, creatinine values were significantly lower in measurements performed by the dry chemistry method in comparison to JaffÃ© assay (p<0.0001) when patients are under metamizole treatment. A significant bias (-40.3%) was observed between those two methods, leading to a significant difference (p<0.0001) in patient classification according to renal function using the CKD-EPI equation for dosing adjustment. Thus, during the validity of metamizole treatment, the stratification for drug dosing by the estimated glomerular filtration rate is not reliable if the creatinine measurement is done through dry chemistry. Clinical and laboratory staff must be aware of these limitations and cooperate to optimize pharmacotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%