<i>In Vitro</i> Effect and Mechanism of Action of Ergot Alkaloid Dihydroergocristine in Chemoresistant Prostate Cancer Cells

Bai, Lijuan; Li, Xin; Ma, Xiaowei; Zhao, Rui; Wu, Daqing

doi:10.21873/anticanres.14626

Cited by 4 publications

(2 citation statements)

References 63 publications

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“…Ergot alkaloids such as dehydroergocristine was approved to treat this chemo resistant prostate cancer. The effects of the drug were reported by quantitative PCR, Western blot analysis and reporter assay 63 . These EA are also applied in ocular pharmacology.…”

Section: Therapeutic Applicationsmentioning

confidence: 99%

Updated Review on Extraction, Isolation and Quantitative Estimation of Ergot Alkaloids

Theja

Sowmya

Kuber

2022

Bulletin of Pharmaceutical Sciences. Assiut

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Ergot Alkaloids are potent α-blockers that cause direct smooth muscle contraction. They are products of fungi in the genus Claviceps. The most prominent member of this group is Claviceps purpurea (rye ergot fungus). Their common sources include Rye, bread as well as other grains. These are nitrogen derived-natural substances which are grouped under indole alkaloids. These ergot alkaloids are a diverse category of secondary metabolites that have been classified into 3 groups as Clavines, Amides of lysergic acid, Ergopeptines and Lactum ergot alkaloids based on their bond arrangement. They contaminate a large variety of cereals such as rye triticale, wheat and barley. In this present review, basic information regarding the ergots along with their chemistry, extraction, purification and isolation procedures for ergot alkaloids were focused, that helps to produce a purified crude extract that is taken for chromatographic analysis. This review also provides detailed informations on the chromatographic approaches for the ergot alkaloids estimations such as TLC, HPLC, HPTLC, UPLC /UHPLC, LCMS, GCMS with different detection techniques like Mass spectrometry and Fluorescence detection which was done in the past decade and also provides information regarding the pharmacological activity of ergot alkaloids like its application in the treatment of severe, throbbing headaches such as migraine, cluster headaches and also other therapeutic applications.

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Section: Therapeutic Applicationsmentioning

confidence: 99%

Updated Review on Extraction, Isolation and Quantitative Estimation of Ergot Alkaloids

Theja

Sowmya

Kuber

2022

Bulletin of Pharmaceutical Sciences. Assiut

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“…Alkaloids are, at present, an interesting group for medicinal chemicals because of the large number of new molecules yet to be discovered from unexplored species and the broad range of applications that enable some drugs to be repurposed for other diseases [ 16 , 17 , 18 , 19 ]. In this line, chloroquine has attracted much attention due to its potential applications for antiviral treatment.…”

Section: Overview Of Alkaloids In the 21st Centurymentioning

confidence: 99%

Alkaloids as Photosensitisers for the Inactivation of Bacteria

et al. 2021

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Antimicrobial photodynamic therapy has emerged as a powerful approach to tackle microbial infections. Photodynamic therapy utilises a photosensitiser, light, and oxygen to generate singlet oxygen and/or reactive oxygen species in an irradiated tissue spot, which subsequently react with nearby biomolecules and destroy the cellular environment. Due to the possibility to irradiate in a very precise location, it can be used to eradicate bacteria, fungus, and parasites upon light activation of the photosensitiser. In this regard, natural products are low-cost molecules capable of being obtained in large quantities, and some of them can be used as photosensitisers. Alkaloids are the largest family among natural products and include molecules with a basic nature and aromatic rings. For this study, we collected the naturally occurring alkaloids used to treat microorganism infections using a photodynamic inactivation approach. We gathered their main photophysical properties (excitation/emission wavelengths, quantum yields, and oxygen quantum yield) which characterise the ability to efficiently photosensitise. In addition, we described the antibacterial activity of alkaloids upon irradiation and the mechanisms involved in the microorganism killing. This review will serve as a reference source to obtain the main information on alkaloids used in antimicrobial photodynamic therapy.

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DHEC mesylate attenuates pathologies and aberrant bisecting N-glycosylation in Alzheimer's disease models

Wang,

Cao,

Huang

et al. 2024

Neuropharmacology

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In Vitro Effect and Mechanism of Action of Ergot Alkaloid Dihydroergocristine in Chemoresistant Prostate Cancer Cells

Cited by 4 publications

References 63 publications

Updated Review on Extraction, Isolation and Quantitative Estimation of Ergot Alkaloids

Updated Review on Extraction, Isolation and Quantitative Estimation of Ergot Alkaloids

Alkaloids as Photosensitisers for the Inactivation of Bacteria

DHEC mesylate attenuates pathologies and aberrant bisecting N-glycosylation in Alzheimer's disease models

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