<i>In vitro</i> dissolution studies on commercial brands containing immediate release pioglitazone and metformin hydrochloride extended release tablets

Soumya, K.; Susanna, S.; Murthy, T. E. G. K.

doi:10.5958/0975-4377.2017.00003.9

Rese. Jour. Pharmaceut. Dosag. Form. and Technol.

2017

DOI: 10.5958/0975-4377.2017.00003.9

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In vitro dissolution studies on commercial brands containing immediate release pioglitazone and metformin hydrochloride extended release tablets

K. Soumya¹,

S. Susanna²,

T. E. G. K. Murthy³

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Cited by 3 publications

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Vitamin D as add on Therapy to Metformin and Teneligliptin in patients with type 2 Diabetes Mellitus

Ahmad Khan,

Chandra,

Lal Kanojia

2023

RJPT

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A low level of vitamin D is being attributed to the development of diabetes, which can cause insulin resistance, beta-cell death, and inflammation. Vitamin D supplementation can reduce inflammation and insulin resistance. we conducted this study for our population to evaluate the effect of vitamin D on blood glucose in type 2 diabetes mellitus. A prospective interventional, parallel, randomized study, was conducted on 112 type two diabetes and 25(OH) D deficient patients. The control group received Metformin (500mg BD) and Teneligliptin (20mg OD) only, while the intervention group was given Metformin plus Teneligliptin along with vitamin D (Cholecalciferol) (60,000 IU). At the end of 3rd of month follow-up, there was a significant difference in mean FPG and PPG (129.86±7.36mg/dl) vs. (136.12±11.31mg/dl) (p=0.002), (220.81±13.04mg/dl) vs. (228.06±19.40 mg/dl) (p=0.037). in the interventional and control group respectively. And subsequently, mean HbA1c improved significantly in the interventional group as compared to the control group 7.21±0.40% vs. 7.48.0.62% respectively (p = 0.015). also, the measures of glycemic control (FPG, PPG, HbA1c) showed a significant improvement at the end of the 6 months. Our study suggested, that add-on therapy of Vitamin D improved the glycemic parameters of type two diabetes mellitus with concurrent vitamin D deficiency over the course of the study.

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Vitamin D as add on Therapy to Metformin and Teneligliptin in patients with type 2 Diabetes Mellitus

Ahmad Khan,

Chandra,

Lal Kanojia

2023

RJPT

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The Influence of the coating on the release of Ibuprofen from the Tablet: Comparative Dissolution Study of the different types of coating

Bennani,

Cherif Chefchaouni,

Benhaddou

et al. 2023

RJPT

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Ibuprofen is a non-steroidal anti-inflammatory drug known for its remarkable therapeutic effects. It can be available in different forms among which are coated and sugar-coated tablets.The objective of this study was to compare the dissolution profile between these two forms. The study was conducted with 5 ibuprofen drugs: 3 generics and one reference drug based on coated tablets, and one drug containing the coated tablets.The parameters used to evaluate and compare the dissolution profiles were the similarity (f2) and difference (f1) factors.The results obtained showed similar dissolution profiles for the two types of coating, with a more significant release for the sugar-coated tabletsduring the first 30 minutes.Dissolution studies are important studies to establish equivalence between generic and brand name drugs, and also to predict the release of the AP.

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Comparison of In vitro Dissolution Tests of five brands of Diclofenac Sodium delayed release tablets in Moroccan market

Bennani,

Benhaddou,

Chefchaouni

et al. 2024

RJPT

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This study aims to evaluate the similarity of in-vitro dissolution profiles, of commercially available generics of diclofenac sodium delayed-release tablets, of 25mg strength, with the innovator brand in Moroccan Market. Dissolution profiles for five brands were determined using the paddle method from the United States Pharmacopoeia. For the aptitude verification of the method, in our experimental conditions, linearity and accuracy tests were performed. The rate of dissolution was determined by Ultra-Violet Spectroscopy at 276nm. The assessment between the generics and the brand medicine was carried out under the similarity factor approach. We also presented an overview of the dissolution principles of tablet dosage form, and the pharmacopoeia dissolution test recommendations in our case. To compliance with US pharmacopoeia specifications, the rate of dissolution should be not more than 10% after 2hours in the acid stage, and not less than 75% at 45 minutes in the buffer stage. Furthermore, two dissolution profiles are considered similar when the f2 value is ≥50. According to routine quality control, evaluating the rate dissolution at the final point, all the generic medicines marketed in Morocco, meet the specification of the dissolution testing. However, using the comparison of dissolution profiles, only generic-2 is interchangeable with the innovator brand.

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In vitro dissolution studies on commercial brands containing immediate release pioglitazone and metformin hydrochloride extended release tablets

Cited by 3 publications

References 0 publications

Vitamin D as add on Therapy to Metformin and Teneligliptin in patients with type 2 Diabetes Mellitus

Vitamin D as add on Therapy to Metformin and Teneligliptin in patients with type 2 Diabetes Mellitus

The Influence of the coating on the release of Ibuprofen from the Tablet: Comparative Dissolution Study of the different types of coating

Comparison of In vitro Dissolution Tests of five brands of Diclofenac Sodium delayed release tablets in Moroccan market

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