In vitrodifferentiation of mouse pluripotent stem cells into glucocorticoid-producing adrenocortical cells
Ioannis Oikonomakos,
Melina Tedesco,
Fariba Jian Motamedi
et al.
Abstract:SummaryDirected differentiation of pluripotent stem cells into specialized cell types represents an invaluable tool for a wide range of applications. Here, we have exploited single-cell transcriptomic data to develop a step-wisein vitrodifferentiation system from mouse embryonic stem cells into adrenocortical cells. We show that during development the adrenal primordium is embedded in an extracellular matrix containing tenascin and fibronectin. Culturing cells on fibronectin during differentiation increased th… Show more
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