<i>In vitro</i> Cytotoxic and Apoptotic activities of <i>Morinda pubescens</i> leaves on HL-60 Cell Line

J, Bharath.; Indumathy, R

doi:10.5958/0974-360x.2019.00951.x

Cited by 1 publication

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“…3, Fig. 4 ) depict clearly that there was good level of anti-cancer activity exhibited by ginger oleoresin against liver cancer cell line when compared with the previous in vitro study performed by [21,22] to analyze the anticancer activity of ginger against cholangiocarcinoma also proved that there is a remarkable anticancer activity for the extract, but both the studies were with different cell line, parameter but both the study results were quite similar.…”

Section: Discussionsupporting

confidence: 53%

Green Synthesis of Copper Nanoparticles Using Ginger Oleoresin and Evaluation of its Anticancer Activity against Liver Cancer Cell Line

Kumar

Anitha

Rajeshkumar

et al. 2021

JPRI

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Introduction: Nanotechnology is getting used in developing countries to assist, treat disease, and stop health issues. Nanotechnology in addition to nanomedicine is being applied to or developed for application to a spread of commercial and purification processes. Ginger, scientifically known as Zingiber officinale, belongs to the family Zingiberaceae. Aim: The aim of the study was to green synthesis copper nanoparticles using ginger oleoresin and to evaluate its cytotoxic activity against liver cancer cells. Materials and Methods: The Ginger oleoresin was obtained from Synthite Industries Private Limited, Kerala with a product code: 4010000370 was used for the study. Copper nanoparticles were prepared from oleoresin and confirmed using UV-Visible spectroscopy. The prepared copper nanoparticles were then evaluated for the anticancer effect on liver cancer cells using the method of Mosmann. The cells (1 × 105 cells per ml) were seeded in a 96 well microtiter plate (100 μl per well) with replications. Different concentration (control, 10, 20, 30, 40, and 60 μg/ml) of ginger oleoresins mediated copper nanoparticles were tested for the anticancer activity. The percentage of cell viability was calculated. Results: Dose-dependent anticancer activity was observed with ginger oleoresins mediated copper Nanoparticles. The IC 50 value was 30 mg / ml Conclusion: In the present study, ginger oleoresin showed a good activity cytotoxic effect on liver cancer cell lines. However, more research is needed to understand the underlying mechanisms of the cytotoxic property of the ginger plant.

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Section: Discussionsupporting

confidence: 53%