<i>In vitro</i> biocompatibility and bioactivity of calcium silicate‑based bioceramics in endodontics (Review)

Song, Wuzhou; Li, Shue; Tang, Qingming; Chen, Lili; Zhu, Yuan

doi:10.3892/ijmm.2021.4961

Cited by 37 publications

(27 citation statements)

References 285 publications

(371 reference statements)

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“…The findings support the fact that MTA can store Calcium Hydroxide ions over a longer period and releases them slowly over time. 23 Studies have been done which evaluated outcomes with percentages with success of 97.96% in favor of MTA 24 but the results of this study have been provided in quantitative data which is more accurate and gave exact values of mean dentin thickness. MTA has produced greater thickness of dentin bridge at both 3 months and 6 months, despite its disadvantages it has proven to be a superior material over Ca(OH) 2 .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Calcium Hydroxide and Mineral Trioxide Aggregate in the Formation of Dentin Bridge – A Randomized Controlled Trial

Ruaaz¹

2022

J Pak Dent Assoc

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OBJECTIVE: This study is to compare the dentin bridge thickness achieved using calcium hydroxide and MTA using radiographs. METHODOLOGY: Single blinded randomized controlled trial conducted in the Operative Dentistry department at Fatima Jinnah Dental College and Hospital, Karachi. A total of 100 premolar and molar teeth with class I and II cavities were included in this study. The study participants were assigned into two groups, A and B of 50 participants each. Under local anesthesia, Group A was indirectly pulp capped with Calcium hydroxide (Dycal) and Group B received Mineral Trioxide Aggregate as an indirect pulp capping material. Both groups were then restored with Glass Ionomer Cement. Radiographic follow up was carried out at three and six months to determine mean dentin thickness of reparative dentin bridge. RESULTS: Statistical analysis was performed using SPSS v 23. Independent Sample t-test was applied to evaluate the formation of dentin bridge formation using Ca(OH)2 and MTA at 3 months & 6 months, the outcomes were highly significant (p-value<0.001). Paired sample t-test was applied to evaluate the difference in dentin bridge formation at three months and 6 months, the results were highly significant (p-value <0.001). CONCLUSION: Statistically significant difference was observed in the dentin thickness of reparative dentin bridge amongst the two groups after three months and six months. A greater success rate was noted in the MTA group as compared to the Ca(OH)2 group after 6 months. KEYWORDS: Dentin bridge, Endodontic treatment, Indirect pulp capping, Reparative dentin, randomized controlled trial.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Calcium Hydroxide and Mineral Trioxide Aggregate in the Formation of Dentin Bridge – A Randomized Controlled Trial

Ruaaz¹

2022

J Pak Dent Assoc

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“…Among them, Biodentine (Septodont, Saint-Maur-Des-Fossés, France), a tricalcium silicate-based cement presented in a powderliquid format, has been extensively studied. Together with the Portland cement-based material Mineral Trioxide Aggregate or MTA, it is being used as the reference hydraulic silicate-based cement (14).…”

Section: Introductionmentioning

confidence: 99%

Comparative Biological Properties and Mineralization Potential of 3 Endodontic Materials for Vital Pulp Therapy: Theracal PT, Theracal LC, and Biodentine on Human Dental Pulp Stem Cells

Sanz

Soler-Doria

López‐García

et al. 2021

Journal of Endodontics

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…In addition to its antimicrobial property, it has been shown to inhibit osteoclastogenesis due to the hydroxyl group providing an alkaline environment that allows for repair and calcification. This environment effectively acts on the osteoclast by inhibiting lactic acid secretions and activating alkaline phosphatase, which is crucial in hard tissue formation [48]. In cases of periapical infection with large periapical lesion, Ca(OH) 2 acts as an intra appointment intracanal medicament.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Oregano Essential Oil Extract in the Inhibition of Bacterial Lipopolysaccharide (LPS)-Induced Osteoclastogenesis Using RAW 264.7 Murine Macrophage Cell Line—An In-Vitro Study

et al. 2021

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Gram-negative, anaerobic bacterias are predominate in periapical infections. The bacterial lipopolysaccharide (LPS) initiates the process of inflammation and periapical bone resorption. Usage of various medicaments retards or inactivates the bacterial endotoxin (LPS). However, the results are not highly effective. In recent years, owing to antimicrobial resistance, the shift from conventional agents to herbal agents has been increased tremendously in research. Keeping this in mind, the present study was formulated to evaluate the efficacy of oregano essential oil in inhibiting bacterial LPS- induced osteoclastogenesis. Four different concentrations (0 ng/mL, 25 ng/mL, 50 ng/mL, and 100 ng/mL) of oregano essential oil extract were added into 96-well culture plate. Under light microscope, quantification of osteoclast cells was performed. One-way ANOVA with post-hoc Tukey test was carried out on SPSS v21. A significant reduction (p < 0.001) in the osteoclast was observed in the experimental groups compared to no oregano essential oil extract (control). A dose-dependent significant reduction (p < 0.001) in osteoclast formation was observed among the experimental groups, with lesser osteoclast seen in group IV with 100 ng/mL of oregano essential oil extract. Thus, it can be concluded that oregano essential oil extract can be utilized as a therapeutic agent that can target bacterial LPS-induced osteoclastogenesis. However, randomized controlled studies should be conducted to assess the potential use of this extract in the periapical bone resorption of endodontic origin.

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In vitro biocompatibility and bioactivity of calcium silicate‑based bioceramics in endodontics (Review)

Cited by 37 publications

References 285 publications

Efficacy of Calcium Hydroxide and Mineral Trioxide Aggregate in the Formation of Dentin Bridge – A Randomized Controlled Trial

Efficacy of Calcium Hydroxide and Mineral Trioxide Aggregate in the Formation of Dentin Bridge – A Randomized Controlled Trial

Comparative Biological Properties and Mineralization Potential of 3 Endodontic Materials for Vital Pulp Therapy: Theracal PT, Theracal LC, and Biodentine on Human Dental Pulp Stem Cells

Efficacy of Oregano Essential Oil Extract in the Inhibition of Bacterial Lipopolysaccharide (LPS)-Induced Osteoclastogenesis Using RAW 264.7 Murine Macrophage Cell Line—An In-Vitro Study

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