<i>In vitro</i>arrhythmia generation by mild hypothermia: a pitchfork bifurcation type process

Xu, Binbin; Jacquir, Sabir; Laurent, Gabriel; Binczak, Stéphane; Pont, Oriol; Yahia, Hussein

doi:10.1088/0967-3334/36/3/579

Cited by 4 publications

(1 citation statement)

References 56 publications

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“…Below 30°C, cardiac arrest becomes a real concern due to an increased risk of ventricular fibrillation. 49 Contractility is also affected; at 25°C cardiac output decreases to approximately 45% of normal values. 50…”

Section: Extreme Hypothermia and The Heartmentioning

confidence: 99%

Editor’s Choice- Inside the cold heart: A review of therapeutic hypothermia cardioprotection

Chavez

León

Einav

et al. 2016

European Heart Journal: Acute Cardiovascular Care

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Targeted temperature management has been originally used to reduce neurological injury and improve outcome in patients after out-of-hospital cardiac arrest. Myocardial infarction remains a major cause of death in the world and several investigators are studying the effect of mild therapeutic hypothermia during an acute cardiac ischemic injury. A search on MEDLINE, Scopus and EMBASE databases was conducted to obtain data regarding the cardioprotective properties of therapeutic hypothermia. Preclinical studies have shown that therapeutic hypothermia provides a cardioprotective effect in animals. The proposed pathways for the cardioprotective effects of therapeutic hypothermia include stabilization of mitochondrial permeability, production of nitric oxide, equilibration of reactive oxygen species, and calcium channels homeostasis. Clinical trials in humans have yielded controversial results. Current trials are therefore seeking to combine therapeutic hypothermia with other treatment modalities in order to improve the outcomes of patients with acute ischemic injury. This article provides a review of the hypothermia effects on the cardiovascular system, from the basic science of physiological changes in the human body and molecular mechanisms of cardioprotection to the bench of clinical trials with therapeutic hypothermia in patients with acute ischemic injury.

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Section: Extreme Hypothermia and The Heartmentioning

confidence: 99%

Editor’s Choice- Inside the cold heart: A review of therapeutic hypothermia cardioprotection

Chavez

León

Einav

et al. 2016

European Heart Journal: Acute Cardiovascular Care

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Nonlinear dynamics of two-dimensional cardiac action potential duration mapping model with memory

2019

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Quantification of Contractile Dynamic Complexities Exhibited by Human Stem Cell-Derived Cardiomyocytes Using Nonlinear Dimensional Analysis

Hoang

Jacquir

Lemus

et al. 2019

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Understanding the complexity of biological signals has been gaining widespread attention due to increasing knowledge on the nonlinearity that exists in these systems. Cardiac signals are known to exhibit highly complex dynamics, consisting of high degrees of interdependency that regulate the cardiac contractile functions. These regulatory mechanisms are important to understand for the development of novel in vitro cardiac systems, especially with the exponential growth in deriving cardiac tissue directly from human induced pluripotent stem cells (hiPSCs). This work describes a unique analytical approach that integrates linear amplitude and frequency analysis of physical cardiac contraction, with nonlinear analysis of the contraction signals to measure the signals’ complexity. We generated contraction motion waveforms reflecting the physical contraction of hiPSC-derived cardiomyocytes (hiPSC-CMs) and implemented these signals to nonlinear analysis to compute the capacity and correlation dimensions. These parameters allowed us to characterize the dynamics of the cardiac signals when reconstructed into a phase space and provided a measure of signal complexity to supplement contractile physiology data. Thus, we applied this approach to evaluate drug response and observed that relationships between contractile physiology and dynamic complexity were unique to each tested drug. This illustrated the applicability of this approach in not only characterization of cardiac signals, but also monitoring and diagnostics of cardiac health in response to external stress.

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In vitroarrhythmia generation by mild hypothermia: a pitchfork bifurcation type process

Cited by 4 publications

References 56 publications

Editor’s Choice- Inside the cold heart: A review of therapeutic hypothermia cardioprotection

Editor’s Choice- Inside the cold heart: A review of therapeutic hypothermia cardioprotection

Nonlinear dynamics of two-dimensional cardiac action potential duration mapping model with memory

Quantification of Contractile Dynamic Complexities Exhibited by Human Stem Cell-Derived Cardiomyocytes Using Nonlinear Dimensional Analysis

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