<i>In Vitro</i>Antiplasmodial Activity of Sesquiterpene Lactones from<i>Ambrosia tenuifolia</i>

Sülsen, Valeria P.; Yappu, D. Gutierrez; Laurella, Laura C.; Anesini, Claudia; Turba, Alberto Giménez; Martino, Virginia; Muschietti, Liliana

doi:10.1155/2011/352938

Cited by 10 publications

(6 citation statements)

References 11 publications

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“…Fractionation of organic extract of A. scabra has been previously described [23]. A pure compound, compound B, was obtained from fractions F 5AS(70–74) by crystallization from ethyl acetate.…”

Section: Methodsmentioning

confidence: 99%

“…Five days after infection, the presence of circulating parasites was confirmed by the microhematocrit method [23]. Mice were treated daily with compound A or benznidazole (1 mg/kg of body weight/day) for five consecutive days (days 5 to 10 postinfection) by the intraperitoneal route.…”

Section: Methodsmentioning

confidence: 99%

“…In Argentina, the genus Ambrosia that belongs to this family is represented by three species: A. tenuifolia , A. scabra and A. elatior . Considering the limitations of current therapies for Chagas disease and leishmaniasis and our previous promising findings on the antiprotozoal activity of terpenoids from the genus Ambrosia [20]–[23], the aim of the present work was to isolate further bioactive compounds from A. elatior and A. scabra .…”

Section: Introductionmentioning

confidence: 99%

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Natural Terpenoids from Ambrosia Species Are Active In Vitro and In Vivo against Human Pathogenic Trypanosomatids

et al. 2013

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Among the natural compounds, terpenoids play an important role in the drug discovery process for tropical diseases. The aim of the present work was to isolate antiprotozoal compounds from Ambrosia elatior and A. scabra. The sesquiterpene lactone (STL) cumanin was isolated from A. elatior whereas two other STLs, psilostachyin and cordilin, and one sterol glycoside, daucosterol, were isolated from A. scabra. Cumanin and cordilin were active against Trypanosoma cruzi epimastigotes showing 50% inhibition concentrations (IC50) values of 12 µM and 26 µM, respectively. Moreover, these compounds are active against bloodstrean trypomastigotes, regardless of the T. cruzi strain tested. Psilostachyin and cumanin were also active against amastigote forms with IC50 values of 21 µM and 8 µM, respectively. By contrast, daucosterol showed moderate activity on epimastigotes and trypomastigotes and was inactive against amastigote forms. We also found that cumanin and psilostachyin exhibited an additive effect in their trypanocidal activity when these two drugs were tested together. Cumanin has leishmanicidal activity with growth inhibition values greater than 80% at a concentration of 5 µg/ml (19 µM), against both L. braziliensis and L. amazonensis promastigotes. In an in vivo model of T. cruzi infection, cumanin was more active than benznidazole, producing an 8-fold reduction in parasitemia levels during the acute phase of the infection compared with the control group, and more importantly, a reduction in mortality with 66% of the animals surviving, in comparison with 100% mortality in the control group. Cumanin also showed nontoxic effects at the doses assayed in vivo, as determined using markers of hepatic damage.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Natural Terpenoids from Ambrosia Species Are Active In Vitro and In Vivo against Human Pathogenic Trypanosomatids

et al. 2013

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“…Molecular structures of several common artemisinin monomers are shown in Figure 1. (Lai et al, 2013) Artemisinin and its derivatives Artemisinin is a sesquiterpene lactone, an antimalarial substance, is obtained on large scale from dried leaves of Artemisia annua L. (Usuda et al, 2000;Widmer et al, 2007;Sulsen et al, 2011;Kumar et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Exploring Artemisia annua L., artemisinin and its derivatives, from traditional Chinese wonder medicinal science

Shahrajabian

Sun

Cheng

2020

Not Bot Horti Agrobo

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Artemisia annua L. (Chinese wormwood herb, Asteraceae) synthesizes artemisinin, which is known as qinghaosu, considers as a unique sesquiterpene endoperoxide lactone. In traditional Chinese medicine, it has been used for the treatment of fevers and haemorrhoides. More researches on Artemisia annua L. and its derivatives, especially artemisinin and other metabolites will help to increase the knowledge and value of A. annua and its constituents. Phenolics from Artemisia annua consists of coumarins, flavones, flavonols, phenolic acids, and miscellaneous. Artemisinin has attracted much attention from scientists due to its potent antimalarial properties as secondary metabolites. Moreover, more attentions are focusing on the roles of artemisinin and its derivatives in treating obesity and metabolic diseases. They also have anti-bacterial, anti-inflammatory, anti-tumor, anti-protozoa, anti-helminthic, anti-fungal, anti-angiogenic and antiproliferation properties. The most important derivatives of Artemisia annua L. are arteether, artemether, artemiside, artemisinin, artemisone, artesunate, and dihydroartemisinin. Artemisinin also use against some cancers such as liver cancer, brain glioma, leukemia, nasopharyngeal cancer, gallbladder cancer, gastric cancer, cervical cancer, lung cancer, breast cancer and colon cancer. This important gift from ancient Chinese traditional medicine can guarantee health of people all around the world. Further researches should be done on the new advances and development of artemisinin and its derivatives as potential natural medicine in the global fight against so many diseases, malaria included.

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“…Moreover, artemisinin derivatives are effective against viruses (Efferth et al 2008 ), protozoans (e.g. Toxoplasma gondii (de Oliveira et al, 2009 ); Trypanosoma cruzi (Sülsen et al, 2008 ); and Plasmodium falciparum (Sülsen et al, 2011 ), flatworms (e.g. Schistosoma japonicum , Schistosoma mansoni , Fasciola hepatica , Clonorchis sinensis (Fathy, 2011 ), bacteria and mushrooms (Lopes-Lutz et al 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Artemisia annua L. as a plant with potential use in the treatment of acanthamoebiasis

et al. 2016

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The treatment of acanthamoebiasis is a great problem. Most cerebral invasions end with death, and the treatment of ocular invasions is usually long-lasting and not very effective. Numerous plant extracts and substances isolated from plants, which are effective against trophozoites or cysts, have been studied in the treatment of acanthamoebiasis. However, no agents that are simultaneously effective against both developing forms of amoebae have been discovered yet. It seems that such a plant which fulfils both tasks is Artemisia annua L. Our studies showed that water, alcohol and chloroform extracts from the herb A. annua L. can be applied in general and local treatment or in combined therapy with antibiotics in the treatment of acanthamoebiasis. Extracts from this plant show not only in vitro but also in vivo effects. Studies carried out on experimental animals infected with amoebae show that the application of these extracts significantly prolongs the survival of the animals.

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In VitroAntiplasmodial Activity of Sesquiterpene Lactones fromAmbrosia tenuifolia

Cited by 10 publications

References 11 publications

Natural Terpenoids from Ambrosia Species Are Active In Vitro and In Vivo against Human Pathogenic Trypanosomatids

Natural Terpenoids from Ambrosia Species Are Active In Vitro and In Vivo against Human Pathogenic Trypanosomatids

Exploring Artemisia annua L., artemisinin and its derivatives, from traditional Chinese wonder medicinal science

Artemisia annua L. as a plant with potential use in the treatment of acanthamoebiasis

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