<i>In vitro</i>antioxidant and antiproliferative potential of medicinal plants used in traditional Indian medicine to treat cancer

Arul, Albert-Baskar; Numair, Khalid S Al; Alsaif, Mohammed A.; Ignacimuthu, Savarimuthu

doi:10.1179/1351000212y.0000000017

Cited by 46 publications

(32 citation statements)

References 24 publications

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“…[9]. Antimicrobial [10] and anticancer activities [11] were reported for B. maderaspatensis. Some studies on chemical analysis were reported for plant species from genus Blepharis and various phytochemical compounds were identified, such as stigmasterol tetracosanoate [12] and other flavonol glycosides, and blepharisides A and B [13] from B. ciliaris (L.) B.L.Burtt.…”

Section: Introductionmentioning

confidence: 99%

Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities

et al. 2019

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Background: Blepharis linariifolia Pers. (Family: Acanthaceae) is used in traditional medicines as a general tonic and for the treatment of various health problems in Sudan. The main aim of this study was to isolate and identify the major chemical constituents from the aerial parts of B. linariifolia and evaluate their bioactivities. Methods: The dried aerial parts of the plant were extracted successively with 100% acetone and 50% acetone, and thereafter the combined extract was subjected to repeated column chromatography to isolate the main components. Free radical scavenging activity was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical method, and in vitro enzyme inhibitory activities against α-glucosidase, pancreatic lipase, and mushroom tyrosinase were evaluated. Results: From the detailed chemical analysis, verbascoside (1), vanillic acid (2), apigenin (3), and 6″-O-p-coumaroylprunin (4), were isolated and their structures were identified on the basis of their nuclear magnetic resonance (NMR) spectral data. Among the isolated compounds, verbascoside (1) showed the most potent free radical scavenging activity (IC50 = 22.03 ± 0.04 μM). Apigenin (3) and 6″-O-p-coumaroylprunin (4) showed promising inhibitory activities against all tested enzymes. Apigenin (3) showed the most potent inhibitory activity against α-glucosidase and tyrosinase (IC50 = 34.73 ± 1.78 μM and 23.14 ± 1.83 μM, respectively), whereas 6″-O-p-coumaroylprunin (4) showed potent inhibition for lipase (IC50 = 2.25 ± 0.17 μM). Conclusions: Four phenolic compounds were isolated and identified from B. linariifolia acetone extract, which are reported for the first time from this plant. All compounds showed good DPPH free radical scavenging activities, with verbascoside (1) being the most potent. Apigenin (3) was the most active as α-glucosidase and mushroom tyrosinase inhibitor, while 6″-O-p-coumaroylprunin (4) showed potent inhibitory activity for pancreatic lipase.

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Section: Introductionmentioning

confidence: 99%

Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities

et al. 2019

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“…Synthetic drugs are potential against oxidative damage but they have adverse side effects. An alternative approach is to consume natural herbal antioxidants from food supplements and traditional medicines [16,17] . Currently, many herbal antioxidants have been isolated from different plant materials [18] .…”

Section: Discussionmentioning

confidence: 99%

In vitro analysis on bactericidal screening and antioxidant potentiality of leaf and root extracts of Thottea siliquosa (Lam.) Ding Hou. An ethnobotanical plant

Nusaiba¹,

Murugan

2013

Asian Pacific Journal of Tropical Biomedicine

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Objective: Natural products of plant origin are potential source of novel antimicrobial and antioxidative agents. Thottea siliquosa (Lam.) Ding Hou. (T. siliquosa). A medicinal herb used by local tribals for treating various ailments. The present study aims at the phytochemical screening, GC-MS analysis, in vitro antibacterial activity and antioxidant potentiality of root and leaf extracts of T. siliquosa. Methods: Hot continuous Soxhlet extraction, GC-MS analysis, antibacterial analysis by disc diffusion, microdilution assay and antioxidant potentialities by hydroxyl radical and nitric oxide radical scavenging. The data was statistically analyzed. Results: Phytochemical screening of the ethyl acetate and methanolic extract of leaf and root revealed the presence of phenols, alkaloids, tannins and saponin. The extract revealed a pool of phytochemicals by comparison with authentic standards from spectral library. Both the extracts has shown their broad spectrum of inhibition against the selected bacteria Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumonia compared with standard antibiotic drug streptomycin. The extracts showed antioxidant activity by scavenging of free radicals such as hydroxyl and nitric oxide. The IC 50 values of the ethyl acetate extracts leaf and root and standard in this assay were 167.5依0.67, 99.4依1.2, 192依2.5 µg/mL respectively. Similarly those methanolic extracts of leaf and root were 269.5依0.89 and 289.1依2.66 µg/mL respectively. Similarly, ethyl acetate and methanolic extracts also caused a moderate dose-dependent inhibition of nitric oxide with an IC 50 range 65.5依1.55 to 148 依3.09 µg/mL. The inhibitory activities were found to be dose dependent. Conclusion: The present study provides evidence that ethyl acetate and methanol extract of leaf and root of T. siliquosa are potential source of natural antioxidants and bactericidal nature. It is essential that research should continue to isolate and purify the bio active components of this natural plant and use in drug discovery and development.

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“…Later on it has been reported that hexane, ethyl-acetate, and methanolic extracts of A. tristis Roxb. showed antiproliferative properties with minimum side effects as determined in human colon adenocarcinoma cell line (COLO-320-DM) [54].…”

Section: Amaranth As An Anticancermentioning

confidence: 97%

Nutritional Functional Value and Therapeutic Utilization of Amaranth

Soriano-Garcı́a¹,

Aguirre-Díaz²

2020

Nutritional Value of Amaranth

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Amaranthus is a dicotyledonous pseudocereal and one of the New World's oldest crops, having originated in Mesoamerica, and was a major food crop of the Aztecs who named it Huautli or Xtes. Popularity in the cultivation and consumption of Amaranthus seed in the modern era began in the mid-1970s with the rediscovery and promotion of amaranth due to its superior nutritional attributes as compared to cereal grains. Today, amaranth is still included in the human diet because of its nutraceutical relevance. Amaranth is considered as a "superfood" because it contains high nutraceutical values such as a high-quality protein, unsaturated oils, squalene, dietary fiber, tocopherols, tocotrienols, phenolic compounds, flavonoids, vitamins, and minerals. Compared to other grains, amaranth has a higher amount of protein, dietary fiber, calcium, iron, and magnesium; therefore although it is an ancient crop nowadays, it is considered a millennium crop or superfood with relevant nutraceutical values and its agronomic versatility. This comprehensive chapter is focused on amaranth composition and antioxidant properties and provides several potential medical benefits of its valuable components.

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In vitroantioxidant and antiproliferative potential of medicinal plants used in traditional Indian medicine to treat cancer

Cited by 46 publications

References 24 publications

Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities

Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities

In vitro analysis on bactericidal screening and antioxidant potentiality of leaf and root extracts of Thottea siliquosa (Lam.) Ding Hou. An ethnobotanical plant

Nutritional Functional Value and Therapeutic Utilization of Amaranth

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