<i>In vitro</i> Antioxidant and Anticholinesterase Activities of <i>Senecio massaicus</i> Essential Oil and Its Molecular Docking Studies as a Potential Inhibitor of Covid-19 and Alzheimer’s Diseases

Kebbi, Sara; Noman, Labib; Demirtaş, İbrahim; Bensouici, Chawki; Adem, Şevki; Benayache, Fadila; Seghiri, Ramdane; Gok, Mesut

doi:10.1080/22311866.2021.1955006

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…In Algeria, some botanical and natural products are used to treat inflammatory diseases, including gastric ulcers and diarrhea [6]. The genus Senecio, where 18 species, including 5 endemic species, are recorded to Algeria [7]. According to locals, Senecio perralderianus, in folk medicine; used to treat cough, asthma and bronchitis [8].…”

Section: Introductionmentioning

confidence: 99%

Preventing ethanol-induced stomach ulcers in rats using Senecio perralderianus leaf extract

Mamache,

Benabdallah,

Hannachi

et al. 2024

RC FCV-LUZ

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Senecio perralderianus belongs to the family of Asteraceae and is only found in Algeria. Some species of this family are used to heal gastrointestinal issues in conventional medicine for their antioxidant and anti-inflammatory properties. This research was performed in order to determine if methanolic extract from the leaves of S. perralderianus had any protective effects on gastroenteritis brought on by alcohol consumption. Wistar rats were fed with 100% ethanol orally to induce gastric ulcer, and pre-treated with 50, 100, and 200 mg·kg-1 of the extract in addition to 5 mg·kg-1 of Ranitidine as a positive reference drug. The extract had shown a positive effect to protect ethanol-induced gastric ulcers with a protection percentage of 71 to 88%. In addition, pretreatment of rats significantly increased levels of GSH, CAT, and SOD in vivo as non-enzymatic and enzymatic antioxidants, and also reduced the level of lipid peroxidation. Histopathological sections, which showed the action of the therapeutic extract, substantially confirmed these findings on the reduction of the inflammation zone and the reduction of immune cell filtration caused by ethanol toxicity with increased extract dosages compared to Ranitidine. The antiulcer activity is due to inhibition of oxidative stress and gastritis. It is associated with a total polyphenol, flavonoids, chlorophyll (a, b), and carotenoids substantial amounts.

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Section: Introductionmentioning

confidence: 99%

Preventing ethanol-induced stomach ulcers in rats using Senecio perralderianus leaf extract

Mamache,

Benabdallah,

Hannachi

et al. 2024

RC FCV-LUZ

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“…Therefore, it has been reported in many studies that they significantly affect enzyme activities both as extracts and as pure compounds. Many phycochemicals have been reported that specifically affect the enzyme activities of acetylcholinesterase (AChE), Xanthine oxidase (XO), and Tyrosinase (Kebbi et al 2021;Yırtıcı et al 2022). Therefore, the potential effects of the obtained extracts on these three enzymes were investigated in this study.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of insecticidal and enzyme activity potentials of essential oils and extracts of Chenopodium botrys against storage products pests

TÜFEKÇİ,

AKŞİT,

ŞİMŞEK

et al. 2023

Bulletin of Biotechnology

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The essential oil obtained from the aerial part of Chenopodium botrys plant by steam distillation was obtained. The remaining aqueous part was extracted with the solvent ethylacetate and n-butanol, respectively. In the end, five extracts were obtained: essential oil (CB-EO), untreated aqueous extract (CB-F), ethylacetate (CB-EA), n-butanol (CB-nBu) and processed aqueous extract (CB-L). The effects of five extracts on both insecticidal (against Sitophilus granarius and Tribolium castaneum) and enzyme activities (acetylcholinesterase, xanthine oxidase (XO) and tyrosinase) were studied. It has been determined that CB-F extract has an activation effect against tyrosinase enzyme. At the end of 48 hours, CB-EA extract was determined to cause 20% death against the adult insects of Sitophilus granarius as a result of contact toxicity test. As a result of GC-MS analysis of essential oil, α-Eudesmol compound was analyzed as the main component

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Analysis of Volatiles in Senecio anteuphorbium Essential Oil with a Focus on Its Allelopathic Effect by Means of Gas Chromatography

et al. 2022

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The present study aimed to investigate Senecio anteuphorbium, an endemic plant growing in West Morocco and widely used in local folk medicine. The essential oil (EO) extracted from the aerial parts was analyzed by gas chromatography and tested for allelopathic activity. The quantitation of the volatiles was carried out by means of GC-FID with response factors, which were validated through reliable calibration procedures, based on external and internal standardization. This analytical approach allowed to define the real concentration of each constituent (weight%, g/100 g) alongside the conventional relative percent. On the other hand, the identification process was supported by a dual matching based on both mass spectra and retention indices. The essential oil resulted in being rich in sesquiterpenes, with the predominant constituents being bicyclogermacrene (22.75 g/100 g), spathulenol (25.26 g/100 g), epi-γ-eudesmol (6.8 g/100 g), and selina-4,11-diene (5.08 g/100 g). The allelopathic effect was evaluated by studying the inhibition of the germination and growth of Lactuca sativa seeds. A potent allelopathic effect was recorded by the essential oil at a dose of 0.281 mg/mL, with almost a total inhibition of germination.

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In vitro Antioxidant and Anticholinesterase Activities of Senecio massaicus Essential Oil and Its Molecular Docking Studies as a Potential Inhibitor of Covid-19 and Alzheimer’s Diseases

Cited by 3 publications

References 44 publications

Preventing ethanol-induced stomach ulcers in rats using Senecio perralderianus leaf extract

Preventing ethanol-induced stomach ulcers in rats using Senecio perralderianus leaf extract

Evaluation of insecticidal and enzyme activity potentials of essential oils and extracts of Chenopodium botrys against storage products pests

Analysis of Volatiles in Senecio anteuphorbium Essential Oil with a Focus on Its Allelopathic Effect by Means of Gas Chromatography

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