In vitro anti-trypanosomal activity of 3-(aryl)-6-piperazin1,2,4-triazolo[3,4-a]phthalazines-loaded ultrathin polymeric particles: effect of polymer type and particle size

Abstract

Herein, TF1 and TF2 were successfully encapsulated into PLGA-, PLA- and PCL-microparticle/-nanoparticle systems. The results demonstrate how polymer chain nature and nanoparticle size affect the leishmanicidal activity of encapsulated triazolophthalazines.