In vitro anti-inflammatory, in silico molecular docking and molecular dynamics simulation of oleanane-type triterpenes from aerial parts of Mussaenda recurvata

Abstract

Two new triterpenes recurvatanes A and B were isolated from Mussaenda recurvata using bioactive-guided investigation.

In vitro and in silico docking and molecular dynamic of antimicrobial activities, alpha-glucosidase, and anti-inflammatory activity of compounds from the aerial parts of Mussaenda saigonensis

“…NO inhibition of compounds 1-12 were determined with the same procedure reported previously. 21,22 Dulbecco's Modied Eagle's Medium (DMEM) contained L-glutamine (2 mM), HEPES (10 mM), sodium pyruvate (1 mM), and 10% fetal bovine serum (FBS). RAW 264.7 cells were cultured in DMEM, seeded in 96well culture plates (each well 2 × 10 5 cells), and incubated for 3 days (the tested condition: 37 °C in 5%-CO 2 humidied air).…”

“…20 M. recurvata is thought to be a good source of anti-inammatory chemicals. 21,22 Previous research on this Vietnamese plant found nine anti-inammatory compounds: ve saponins and four oleanane-type triterpenes. 21,22 However, not much is known about Mussaenda saigonensis's chemical and biological data.…”

“…21,22 Previous research on this Vietnamese plant found nine anti-inammatory compounds: ve saponins and four oleanane-type triterpenes. 21,22 However, not much is known about Mussaenda saigonensis's chemical and biological data. The potential of M. recurvata components as alpha-glucosidase and NO inhibitors and the high potent activity of M. saigonensis extracts in these assays encouraged us to investigate the titled plant.…”