In vitro and in vivo study of fosfomycin in methicillin-resistant Staphylococcus aureus septicaemia

Abstract

SUMMARYFive hundred strains of methicillin-resistant Staphylococcus aureus were tested against various anti-staphylococcal agents. Vancomycin, fusidic acid and fosfomycin were found to be the most effective. Only 1 strain out of 500 was resistant to fosfomycin. Three patients with methicillin-resistant Staphylococcus aureus septicaemia were successfully treated by fosfomycin. We conclude that fosfomycin could be the drug of choice for methicillin-resistant Staphylococcus aureus infection.

New therapeutic choices for infections caused by methicillin-resistant Staphylococcus aureus

“…It can be administered in combination (without antagonism) with glycopeptides, linezolid, quinupristin–dalfopristin, β‐lactams, aminoglycosides, ansamycines, nitroimidazoles, and quinolones. A tromethamine derivative can be administered as an oral drug to treat urinary tract infections caused by some Gram‐negative rods and Enterococcus faecalis [161,165–170]. A review of the subject has been recently published [171].…”

In vitro synergism of fosfomycin and clarithromycin antimicrobials against methicillin-resistant Staphylococcus pseudintermedius

“…[ 5 , 6 ]. These organisms tend to work cooperatively to ensure community survival, where some may forfeit active growth [ 7 , 8 ]. As a result, biofilm infections are generally difficult to clear, owing to enhanced microbial resistance and tight adherence to the surface of the substrate [ 6 , 9 ].…”