In-vitroandin-vivostudy of amorphous spironolactone prepared by adsorption method using supercritical CO2

Jiang, Qikun; Li, Yuanyuan; Fu, Qiang; Geng, Yajie; Zhao, Juanhang; Ma, Panqin; Zhang, Tianhong

doi:10.3109/03639045.2013.858731

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Manufacturing Methods For Preparing Amorphous Solid Dispersions1

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Cited by 6 publications

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“…Cosolvents such as methanol can be added to CO 2 to aid drug solubility. However, this necessitates an additional step for removing the residual solvent which increases process complexity and expense 211 , 212 , 213 .…”

Section: Manufacturing Methods For Preparing Amorphous Solid Dispersionsmentioning

confidence: 99%

Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

Bhujbal

Mitra

Jain

et al. 2021

Acta Pharmaceutica Sinica B

260

131

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Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs. Various approaches have been employed to produce ASDs and novel techniques are emerging. This review provides an updated overview of manufacturing techniques for preparing ASDs. As physical stability is a critical quality attribute for ASD, the impact of formulation, equipment, and process variables, together with the downstream processing on physical stability of ASDs have been discussed. Selection strategies are proposed to identify suitable manufacturing methods, which may aid in the development of ASDs with satisfactory physical stability.

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Section: Manufacturing Methods For Preparing Amorphous Solid Dispersionsmentioning

confidence: 99%