Abstract:Exposure of tissue to extreme temperature, corrosive chemicals, ischemia or other noxious stimuli can induce necrotic degeneration that is characterized by cellular swelling, loss of organellar integrity, accumulation of reactive oxygen species, activation of proteases and ultimately cell lysis. Necrosis can be genetically induced in C. elegans neurons by expression of mutant hyperactive ion channels. Mutant DEG/ENaC channels cause entry of excess calcium into the cell, triggering release of ER calcium stores … Show more
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