In VitroandIn VivoGenotoxicity Assessment ofAristolochia manshuriensisKom.

Hwang, Youn–Hwan; Kim, Taesoo; Cho, Won‐Kyung; Yang, Hye Jin; Kwak, Dong Hoon; Ha, Hyunil; Song, Kwang Hoon; Yeul, Jin

doi:10.1155/2012/412736

Cited by 16 publications

(6 citation statements)

References 27 publications

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“…In this study, the comet single cell gel assay demonstrated no evidence that the herbal formulated drug was potentially genotoxic (Figure 7, Figure 8). Certain plants have been demonstrated to be genotoxic due to the content of certain phytochemicals present in them that form adducts with DNA that interfere with normal DNA repair mechanism in various cells 37, 38, 39, 40, 41. In previous studies, capsaicin, which is linked to C. frutescens , has been demonstrated to be carcinogenic in humans 42 .…”

Section: Discussionmentioning

confidence: 99%

Pro-inflammatory and toxicological evaluation of Hepacare ® in mice

Adebayo

Ashano

Yakubu

et al. 2017

Journal of Taibah University Medical Sciences

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Objectives Hepacare ® is a widely marketed herbal formulation in Nigeria for treating chronic liver ailments. This study evaluated the safety, as well as pro-inflammatory and genotoxicity effects, of Hepacare ® in mice. Methods The effect of the formulation was estimated in a 28-day study where 25 mice were divided into five groups, and Hepacare ® was orally administered at 250, 500, 750 and 2500 mg/kg body weight. The biochemical and haematological parameters were determined, organ weights were estimated and histopathology was also conducted. mRNA expression of the pro-inflammatory cytokines, TNF-α and IL-6 was estimated by RT-PCR in acute toxicity experiments. Results The LD 50 was calculated at 3807.89 mg/kg body weight in mice. There was a significant increase (p < 0.05) in the ALP activity in the 750 mg/kg treated group, while the 2500 mg/kg group exhibited significant increases in their AST, ALT, ALP, total bilirubin and total protein levels compared with the control group. However, there was a significant dose related increase in monocytes counts in the groups treated with 750 and 2500 mg/kg. There was no significant difference (p > 0.05) in TNF-α and IL-6 mRNA expression in the genotoxicity studies in all of the treatment groups compared with the control. However, several hepatic and nephro-pathological derangements were observed in the groups treated with higher doses of the formulation. Conclusions The study established that the herbal formulation may not induce significant pro-inflammatory toxic responses and genotoxic effects, but prolonged intake of higher doses may cause severe biochemical and clinical abnormalities.

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Section: Discussionmentioning

confidence: 99%

Pro-inflammatory and toxicological evaluation of Hepacare ® in mice

Adebayo

Ashano

Yakubu

et al. 2017

Journal of Taibah University Medical Sciences

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“…Following the discovery of the nephrotoxic and carcinogenic potentials of aristolochic acids (Vanherweghem et al, 1993), several studies confirmed their genotoxic activity (Kohara et al, 2002; Fang et al, 2011; Hwang et al, 2012). Schmeiser et al (1996) demonstrated the presence of aristolochic acids-related DNA adducts in renal tissues of patients.…”

Section: Toxicity and Adverse Health Effects Of Some Common Herbal Mementioning

confidence: 99%

The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety

2014

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The use of herbal medicinal products and supplements has increased tremendously over the past three decades with not less than 80% of people worldwide relying on them for some part of primary healthcare. Although therapies involving these agents have shown promising potential with the efficacy of a good number of herbal products clearly established, many of them remain untested and their use are either poorly monitored or not even monitored at all. The consequence of this is an inadequate knowledge of their mode of action, potential adverse reactions, contraindications, and interactions with existing orthodox pharmaceuticals and functional foods to promote both safe and rational use of these agents. Since safety continues to be a major issue with the use of herbal remedies, it becomes imperative, therefore, that relevant regulatory authorities put in place appropriate measures to protect public health by ensuring that all herbal medicines are safe and of suitable quality. This review discusses toxicity-related issues and major safety concerns arising from the use of herbal medicinal products and also highlights some important challenges associated with effective monitoring of their safety.

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“…Herbal medicine is generally considered safe in Korea as a consequence of the natural origin of the ingredients that comprise treatments as well as its long-established role in Korean society. However, some toxicological studies have revealed the potential for herbal medicines to induce harmful genetic damage [15][16][17][18]. In other cases, a dearth of toxicity information has occasionally resulted in the misapplication of herbal medicine [19,20].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Genotoxicity Assessment from the Glycyrrhiza New Variety Extract

et al. 2021

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The various species that comprise the genus Glycyrrhiza (Licorice) have long been used as oriental herbal medicines in Asian countries. Wongam (WG), which is a new variety of Glycyrrhiza, was developed in Korea to overcome the limitations of low productivity, environmental restrictions, and an insufficient presence of glycyrrhizic acid and liquiritigenin. In this study, we evaluated WG extract’s genotoxicity through an in vitro bacterial reverse mutation (AMES) test, an in vitro chromosome aberration test, and an in vivo mouse bone marrow micronucleus test. In the AMES test, WG extract at concentrations of up to 5000 µg/plate showed no genotoxicity regardless of S9 mix. No chromosome aberrations appeared after 6 h in 1400 µg/mL WG extract regardless of S9 mix or in 1100 µg/mL WG extract after 24 h without S9 mix. Nor was there a significant increase in the number of micronucleated polychromatic erythrocytes to total erythrocytes up to 5000 mg/kg/day for 2 days detected in the micronucleus test. These results confirm that WG extract is safe for use as an herbal medicine, as it precipitates no detectable genotoxic effects.

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In VitroandIn VivoGenotoxicity Assessment ofAristolochia manshuriensisKom.

Cited by 16 publications

References 27 publications

Pro-inflammatory and toxicological evaluation of Hepacare ® in mice

Pro-inflammatory and toxicological evaluation of Hepacare ® in mice

The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety

In Vitro Genotoxicity Assessment from the Glycyrrhiza New Variety Extract

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