In Vitro and In Vivo Evaluation of desmopressin-loaded poly( D,L -lactic-co-glycolic acid) Nanoparticles for Its Potential Use in Cancer Treatment

Abstract

Aim: To develop and characterize the antitumor activity of poly(D,L-lactic-co-glycolic acid) nanoparticles loaded with hemostatic and anticancer drug desmopressin (dDAVP). Materials & methods: After full physicochemical characterization, anticancer activity of dDAVP-loaded poly(D,L-lactic-co-glycolic acid) nanoparticles (NPdDAVP) was evaluated in vitro and in vivo on a highly aggressive breast cancer model. Results: After efficiently loading desmopressin in poly(D,L-lactic-co-glycolic acid) matrix, NPdDAVP exhibited suitable physicochemical characteristics for biomedical applications. NPdDAVP displayed a potent cytostatic effect in vitro, inhibiting tumor cell proliferation and colony forming ability. Moreover, intravenous treatment using nanoparticulated-dDAVP inhibited tumor progression and prolonged survival in animals bearing rapidly-growing mammary tumors. Conclusion: Within the framework of promising dDAVP repurposing studies, these findings support further preclinical development of the NPdDAVP for the management of highly aggressive cancer.

Therapeutic Polymer-Based Cannabidiol Formulation: Tackling Neuroinflammation Associated with Ischemic Events in the Brain

“…However, CBD’s high hydrophobicity limits its clinical implementation due to the use of high doses needed to achieve a therapeutic effect . To overcome CBD pharmacological drawbacks, polymer carriers can be an innovative strategy to improve efficacy and reduce side effects while maintaining the properties of the entrapped active substances . We deliberately selected a well-studied and widely used polymer to build our CBD carriers due to the enhanced feasibility for clinical translation.…”

“… 17 To overcome CBD pharmacological drawbacks, polymer carriers can be an innovative strategy to improve efficacy and reduce side effects while maintaining the properties of the entrapped active substances. 18 We deliberately selected a well-studied and widely used polymer to build our CBD carriers due to the enhanced feasibility for clinical translation. PLGA has a well-known ability to efficiently accommodate hydrophobic drugs through the solvent evaporation method, and it has an appealing history with FDA regulators.…”

Repurposing of Chronically Used Drugs in Cancer Therapy: A Chance to Grasp

“…Desmopressin is also being evaluated in the Phase II trial as preoperative for breast cancer ( Figure 5 A). The efficacy of desmopressin against different breast cancer cell lines [ 105 , 106 , 107 , 108 ] is through the induction of angiostatin [ 108 ] and inhibition of metastasis [ 109 ]. Interestingly, a novel analog of desmopressin shows more significant antimetastatic and inhibitory effects against breast cancer cells MCF-7 and MDA-MB-231 [ 107 , 108 ].…”

Integrated H2O2 self-supplying PLGA@CQDs–CuPox nanoparticles enabling accumulation of copper during the Fenton reaction

“…Poly(D,L-lactic-co-glycolic acid) (PLGA) is a biodegradable polymer that can be used as an encapsulation agent for drugs, nanomaterials, and various substances. 26,27 Its excellent biocompatibility 28 and multifunctional properties 29 make PLGA an ideal carrier for transporting carbon quantum dots and copper peroxide nanoparticles. Consequently, PLGAcoated CQDs and CuPox nanodots can achieve the controlled release of CQDs and CuPox nanodots in the tumor microenvironment, thereby enhancing the effectiveness of chemodynamic therapy.…”