<i>In vitro</i> and <i>in vivo</i> evaluation of change of local pH on bacteria in C.S.O.M.

Malik, Meenakshi; Dayal, Deen; Khan, Abidullah

doi:10.1017/s0022215100081093

Cited by 8 publications

(7 citation statements)

References 3 publications

(1 reference statement)

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“…Failure of treatment in our study was in 16 % (8 patients) in comparison of 15 % failure rate in study of Hyeog Gi Choi and 20.40 % in the study of Mailk et al 1975 and Chhangani and Goyal but it is insignificant [9,10].…”

Section: Discussionmentioning

confidence: 42%

Role of Acetic Acid Irrigation in Medical Management of Chronic Suppurative Otitis Media: A Comparative Study

Gupta

Agrawal

Gargav

2014

Indian J Otolaryngol Head Neck Surg

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Chronic otitis media is persistent and insidious disease. It is one of the most common bacterial infections in the field of otolaryngology having significant economic and individual repercussion. Medical management of chronic suppurative otitis media (CSOM) for dry ear is essential before surgical treatment. The objective is to consider the most appropriate medical treatment modalities for patients of CSOM. To assess results of acetic acid irrigation and topical and systemic antibiotic in CSOM and consider, the most appropriate medical management. This study was conducted prospectively from Nov 2011 to Sep 2013 in 100 patients of CSOM (tubotympanic type). Patient included in the present study were divided in two groups. In one group patients were treated with aural toilet and irrigation with acetic acid and in other group patients were treated with topical and systemic antibiotic. After a follow up period of 3 months duration results were assessed on the basis of absence of discharge, healing of perforation and status of middle ear. Otorrhoea resolution in group treated with acetic acid was 84 % and healing of perforation was noted in 26 % while failure rate of 16 % was noted. In group treated with topical and systemic antibiotic 58 % of patient shows otorrhoea resolution, 14 % achieve healing of perforation and 32 % had failure. Medical management of CSOM without Cholesteatoma by frequent aural cleaning and irrigation using dilute acetic acid can be more desirable choice as compared to the topical and oral antibiotics.

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Section: Discussionmentioning

confidence: 42%

Role of Acetic Acid Irrigation in Medical Management of Chronic Suppurative Otitis Media: A Comparative Study

Gupta

Agrawal

Gargav

2014

Indian J Otolaryngol Head Neck Surg

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Section: Discussionmentioning

confidence: 99%

“…Antibacterials work by changing the pH of skin to acidic resulting in its effect in bacterial infection. There have been both in vivo and in vitro studies to show the antibacterial effect of acetic acid [4][5][6] and also aluminium acetate. 6 Comparison with other studies A trial of 39 patients showed that adding an aminoglycoside to steroid drops conveys no significant benefit when treating otitis externa, again indicating the beneficial effects of just steroids.…”

Section: Discussionmentioning

confidence: 99%

Prospective randomised single‐blind controlled trial of glacial acetic acid versus glacial acetic acid, neomycin sulphate and dexamethasone spray in otitis externa and infected mastoid cavities

Johnston

Flook

Mehta

et al. 2006

Clinical Otolaryngology

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Glacial acetic acid, dexamethasone and neomycin sulphate is significantly more effective in treating otitis externa when compared with glacial acetic acid. This effect failed to be significant in the infected mastoid cavities group. We therefore recommend that in conjunction with aural toilet, antibiotic/steroid combination is more effective than an antibacterial agent for otitis externa. Larger numbers of infected mastoid cavities are required to be studied.

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“…In this study, Otomycosis was common in those with history of antibiotic ear drops usage (60%) prior to one month of clinical examination, followed by diabetes mellitus (22.9%). Continued usage of ear drops was found to be leading predisposing factor in the study by Malik et al 22 (55%). Liston and Siegel.…”

Section: Predisposing Factorsmentioning

confidence: 93%

Otomycosis in Chronic Otitis Media

B.R¹,

Nath²,

P.S³

2017

jebmh

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BACKGROUNDOtomycosis is a frequently diagnosed entity by an otolaryngologist with non-specific symptoms ranging from pruritus, aural fullness, and ear discharge and ear pain. Accurate diagnosis requires a high degree of suspicion, especially in cases of chronic suppurative otitis Media.The aims of this study were-1. To investigate the prevalence of otomycosis in patients with chronic suppurative otitis media 2. To identify fungal pathogens present in chronic suppurative otitis media. 3. To identify bacterial flora in the ear discharges. MATERIALS AND METHODSPresent study is a Descriptive study. Study population included 322 patients with chronic suppurative otitis media who attended the Department of ENT, Government Medical College, Thiruvananthapuram from February 2013 to January 2014. The discharge specimens were worked on for isolation and culture of bacterial, fungal organism. The results were analysed. RESULTSOtomycosis in chronic suppurative otitis media, mostly affected age group is 21-30, mainly females. House wives and manual labourers were more affected. Prior antibiotic ear drops (60%) and diabetes mellitus (22%) were the common predisposing factors. Cultures revealed Pseudomonas aeruginosa (56%) as the major bacterial pathogen and Aspergillus (75%) as the major fungal pathogen. CONCLUSIONSignificant numbers of cases of chronic suppurative otitis media with otorrhoea have super added fungal infections. It can cause refractoriness to usual topical antibiotic therapy and failure of surgeries. This study also shows that fungal culture is advisable in refractory cases before starting antibiotic therapy.

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In vitro and in vivo evaluation of change of local pH on bacteria in C.S.O.M.

Cited by 8 publications

References 3 publications

Role of Acetic Acid Irrigation in Medical Management of Chronic Suppurative Otitis Media: A Comparative Study

Role of Acetic Acid Irrigation in Medical Management of Chronic Suppurative Otitis Media: A Comparative Study

Prospective randomised single‐blind controlled trial of glacial acetic acid versus glacial acetic acid, neomycin sulphate and dexamethasone spray in otitis externa and infected mastoid cavities

Otomycosis in Chronic Otitis Media

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