In Vitro and in Vivo Anti-Influenza Virus Activity of Diarylheptanoids Isolated from Alpinia Officinarum

Abstract

AO-0002 was suggested to have a different anti-influenza virus action to that of oseltamivir and was verified to show anti-influenza activity in vitro and in vivo.

Kolaviron Improves Morbidity and Suppresses Mortality by Mitigating Oxido-Inflammation in BALB/c Mice Infected with Influenza Virus

“…Thus, a recent paradigm shift includes the search and quest for antiviral, redox regulator and/or anti-inflammatory strategies that could either solely emerge as new antiinfluenza or adjunct therapy combined with the existing arsenal to reduce the severity and complications of influenza infections (1,5,14,18,(45)(46)(47)(48). Data from a number of studies suggest that the use of oxygen free radicals as targets may provide an approach to the amelioration of the pathogenicity caused by influenza virus infections (15,47), and several studies have reported the anti-influenza activity of medicinally potent and disease-preventing plant polyphenols and flavonoids with antioxidant properties (9,17,24,42,47,48).…”

Medicinal Herbs and Plant Extracts for Influenza: Bioactivity, Mechanism of Anti-influenza Effects, and Modulation of Immune Responses

“…When diarylheptanoids isolated from Alpinia officinarum were orally administered to mice infected with influenza A virus, these aromatic compounds significantly reduced body weight and prolonged survival times of infected mice and also reduced viral titers in bronchoalveolar lavage fluids of the lungs. These compounds demonstrated dose-dependent suppression of viral messenger RNA [52].…”

Anticancer Properties of Alpinia officinarum (Lesser Galangal) – A mini review.

“…The anticancer activity of diarylheptanoids isolated from Alpinia officinarum has been reported (8,(9)(10)(11)(12)(13)(14)(15)17,18,28). Table 3 summarizes the biological effects of the main diarylheptanoids purified from the plant.…”

“…More recently, many unique biochemical compounds have been purified from A. officinarum (6,7). Among the most studied of these compounds are galangin and members of a class of compounds known as diarylheptanoids which have been demonstrated to have significant anti-inflammatory, anti-proliferative and anti-emetic properties (3,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) (Tables 2 and 3).…”