In vitro and in vivo testing of the hypocholesterolemic activity of ergosterol- and β-glucan-enriched extracts obtained from shiitake mushrooms (Lentinula edodes)

Morales, Diego; Tejedor-Calvo, Eva; Jurado-Chivato, Noelia; Polo, Gonzalo; Tabernero, María; Ruiz-Rodrı́guez, Alejandro; Largo, Carlota; Soler‐Rivas, Cristina

doi:10.1039/c9fo01744e

Cited by 30 publications

(19 citation statements)

References 30 publications

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“…Its role in the prevention of high cholesterol blood levels ( Table 2 ) could be attributed to the presence of lovastatin, a cholesterol-lowering drug, in its fruiting bodies [ 50 ] and the hypocholesterolemic molecule eritadenine [ 76 ]. Furthermore, a β -glucan-enriched extract of this mushroom was able to profoundly reduce the levels of cholesterol in a mouse model [ 77 ]. Previously, it has been shown that the intake of shiitake mushroom by male Wistar rats significantly reduced cholesterol concentrations in the blood [ 78 ].…”

Section: Resultsmentioning

confidence: 99%

Ethnomycological Investigation in Serbia: Astonishing Realm of Mycomedicines and Mycofood

Živković

Ivanov

Stojković

et al. 2021

JoF

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This study aims to fill the gaps in ethnomycological knowledge in Serbia by identifying various fungal species that have been used due to their medicinal or nutritional properties. Ethnomycological information was gathered using semi-structured interviews with participants from different mycological associations in Serbia. A total of 62 participants were involved in this study. Eighty-five species belonging to 28 families were identified. All of the reported fungal species were pointed out as edible, and only 15 of them were declared as medicinal. The family Boletaceae was represented by the highest number of species, followed by Russulaceae, Agaricaceae and Polyporaceae. We also performed detailed analysis of the literature in order to provide scientific evidence for the recorded medicinal use of fungi in Serbia. The male participants reported a higher level of ethnomycological knowledge compared to women, whereas the highest number of used fungi species was mentioned by participants within the age group of 61–80 years. In addition to preserving ethnomycological knowledge in Serbia, this study can present a good starting point for further pharmacological investigations of fungi.

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Section: Resultsmentioning

confidence: 99%

Ethnomycological Investigation in Serbia: Astonishing Realm of Mycomedicines and Mycofood

Živković

Ivanov

Stojković

et al. 2021

JoF

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“…Detailed studies of the biological effects of fungi have shown that some of them can be attributed to ergosterol ( 2 ) [ 33 , 34 , 35 , 36 , 37 , 38 ]. That is why ergosterol itself has attracted considerable attention as a potential lead for the development of new therapeutics.…”

Section: Sterolsmentioning

confidence: 99%

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

2022

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Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolated from fungal sources. As a rule, further testing is carried out for their biological effects, and many of the isolated compounds exhibit one or another activity. This study aims to review recent literature (mainly over the past 10 years, selected older works are discussed for consistency purposes) on the structures and bioactivities of fungal metabolites of ergosterol. The review is not exhaustive in its coverage of structures found in fungi. Rather, it focuses solely on discussing compounds that have shown some biological activity with potential pharmacological utility.

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“…Shiitake ( Lentinus edodes ), which accounts for 17% of the global edible fungi [ 12 ], is the second most consumed mushroom in the world due to its good texture, nutritious effects. In addition, it illustrates many health promotion effects, such as anti-oxidant and reducing hypercholesterolemia properties, which probably attributed to the ingredients of lentinan (β-1,3-glucan) [ 13 , 14 ]. Shiitake is rich in protein, but low in fat, which is very suitable for the elderly as a nutritionally rich diet [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, it illustrates many health promotion effects, such as anti-oxidant and reducing hypercholesterolemia properties, which probably attributed to the ingredients of lentinan (β-1,3-glucan) [ 13 , 14 ]. Shiitake is rich in protein, but low in fat, which is very suitable for the elderly as a nutritionally rich diet [ 13 , 14 ]. However, its hard texture and requirement of great chewing efforts makes it difficult for the elderly or dysphagia patients.…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Shiitake Mushroom Incorporated with Gums as Dysphagia Diet

Liu

Bhandari

Guo

et al. 2021

Foods

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With the speeding tendency of aging society, the population experienced dysphagia is increasing quickly. Desirable dysphagic diets should be safe, visually appealing and nutritious. 3D printing allows for creation of personalized nutritious foods with regular-like appearance. Shiitake mushroom, rich in protein and bioactive compounds, is suitable for elderly, but its hard texture was not friendly to the elderly with dysphagia. This study investigated the feasibility of production of dysphagic product using shiitake mushroom by 3D printing with various gums addition, including arabic gum (AG), xanthan gum (XG) and k-carrageenan gum (KG) at concentrations of 0.3%, 0.6% and 0.9% (w/w). Data suggested that XG and KG incorporation significantly increased inks’ mechanical strength by decreasing water mobility and promoting the formation of hydrogen bond, enabling 3D printed objects with great self-supporting capacity. The XG containing and KG-0.3% samples were categorized into level 5—minced and moist dysphagia diet within international dysphagia diet standardization initiative (IDDSI) framework. AG addition decreased mechanical strength and viscosity, hardness and self-supporting capacity of 3D printed constructions. AG-0.3% and AG-0.6% samples could not be classified as dysphagia diets based on IDDSI tests. This study provides useful information for dysphagia diet development with appealing appearance by 3D printing.

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In vitro and in vivo testing of the hypocholesterolemic activity of ergosterol- and β-glucan-enriched extracts obtained from shiitake mushrooms (Lentinula edodes)

Abstract: Herein, two shiitake fractions were obtained: the ergosterol-enriched fraction exerted higher in vitro hypocholesterolemic activity and the β-glucan-enriched fraction reduced the cholesterol levels in mice.

Cited by 30 publications

References 30 publications

Ethnomycological Investigation in Serbia: Astonishing Realm of Mycomedicines and Mycofood

Ethnomycological Investigation in Serbia: Astonishing Realm of Mycomedicines and Mycofood

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

3D Printing of Shiitake Mushroom Incorporated with Gums as Dysphagia Diet

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