In vitroandex vivocharacterization of lectin-labeledMycobacterium tuberculosisantigen-containing microspheres for enhanced oral delivery

Yeboah, Kwame G.; Akande, Janet; Addo, Richard T.; Siwale, Rodney C.; Aninkorah-Yeboah, Kwesi; Siddig, Aladin

doi:10.3109/1061186x.2013.833206

Cited by 19 publications

(6 citation statements)

References 43 publications

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“…Consecutive dosing of HBsAg-loaded liposomes decorated with UEA 1 for 3 days elicits maximum serum levels of anti-HBsAg IgG comparable to muscular delivery after three weeks 227 . In addition, mucosal IgA secreted locally is able to migrate to systemic mucosal systems, thus possibly enabling distant mucosal immunity via oral delivery 247 . The vaccines may be released from the vehicles after uptake 165 , but some particles such as glucan microparticles may remain intact in macrophages for a long time.…”

Section: Application Of Lymphatic Transport In Drug Deliverymentioning

confidence: 99%

“…Although natural CMs may work better in prediction, biomimetic CMs are preferred due to lower inter-group variations, reduced number of animals sacrificed and avoidance of tedious operations for separation of natural CMs 73 . The insignificant difference observed between natural and biomimetic CM models justifies the utilization of the latter for drug association study 247 . In addition to basic physicochemical properties of drugs, a series of factors such as addition of surfactants may also matter due to possible alternation of drug solubility 74 .…”

Section: Models For Evaluation Of Lymphatic Transportmentioning

confidence: 99%

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An update on oral drug delivery via intestinal lymphatic transport

Zi-chen

Lü

et al. 2021

Acta Pharmaceutica Sinica B

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Orally administered drug entities have to survive the harsh gastrointestinal environment, penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic circulation. Whereas the gastrointestinal stability can be well maintained by taking proper measures, hepatic metabolism presents as a formidable barrier to drugs suffering from first-pass metabolism. The pharmaceutical academia and industries are seeking alternative pathways for drug transport to circumvent problems associated with the portal pathway. Intestinal lymphatic transport is emerging as a promising pathway to this end. In this review, we intend to provide an updated overview on the rationale, strategies, factors and applications involved in intestinal lymphatic transport. There are mainly two pathways for peroral lymphatic transport—the chylomicron and the microfold cell pathways. The underlying mechanisms are being unraveled gradually and nowadays witness increasing research input and applications.

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Section: Application Of Lymphatic Transport In Drug Deliverymentioning

confidence: 99%

Section: Models For Evaluation Of Lymphatic Transportmentioning

confidence: 99%

An update on oral drug delivery via intestinal lymphatic transport

Zi-chen

Lü

et al. 2021

Acta Pharmaceutica Sinica B

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“…Both lectin-coupled microspheres displayed an affinity for M-cells and showed preferential binding to PP [122] Ulex europaeus 1 agglutinin BSA Liposomes UEA1-functionalized liposomes induced simultaneously both systemic and mucosal immune responses in mice [123] Aleuria aurantia lectin Birch pollen proteins PLGA microspheres…”

Section: Albumin Microspheresmentioning

confidence: 99%

Mimicking microbial strategies for the design of mucus-permeating nanoparticles for oral immunization

Gamazo

Martín-Arbella

Brotons

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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Dealing with mucosal delivery systems means dealing with mucus. The name mucosa comes from mucus, a dense fluid enriched in glycoproteins, such as mucin, which main function is to protect the delicate mucosal epithelium. Mucus provides a barrier against physiological chemical and physical aggressors (i.e., host secreted digestive products such as bile acids and enzymes, food particles) but also against the potentially noxious microbiota and their products. Intestinal mucosa covers 400m(2) in the human host, and, as a consequence, is the major portal of entry of the majority of known pathogens. But, in turn, some microorganisms have evolved many different approaches to circumvent this barrier, a direct consequence of natural co-evolution. The understanding of these mechanisms (known as virulence factors) used to interact and/or disrupt mucosal barriers should instruct us to a rational design of nanoparticulate delivery systems intended for oral vaccination and immunotherapy. This review deals with this mimetic approach to obtain nanocarriers capable to reach the epithelial cells after oral delivery and, in parallel, induce strong and long-lasting immune and protective responses.

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“…The production of the microparticles was by the spray‐drying method. Spray drying is robust with high‐product yield . Furthermore, the technique avoids the toxic chemicals used in solvent evaporation method that would be of great limitation in ophthalmic application …”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Atropine Sulfate in Albumin–Chitosan Microparticles for In Vivo Ocular Drug Delivery

Addo

Yeboah

Siwale

et al. 2015

Journal of Pharmaceutical Sciences

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In vitroandex vivocharacterization of lectin-labeledMycobacterium tuberculosisantigen-containing microspheres for enhanced oral delivery

Abstract: It can be concluded from the study that the lectin-coupled microspheres had better affinity for M-cells and showed preferential binding to the Peyer's patches. This means that the coupling enhanced the targeted delivery of the antigens to the M cells.

Cited by 19 publications

References 43 publications

An update on oral drug delivery via intestinal lymphatic transport

An update on oral drug delivery via intestinal lymphatic transport

Mimicking microbial strategies for the design of mucus-permeating nanoparticles for oral immunization

Formulation and Characterization of Atropine Sulfate in Albumin–Chitosan Microparticles for In Vivo Ocular Drug Delivery

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