In vitro activity of isoimperatorin, alone and in combination, against Mycobacterium tuberculosis

Abstract

This is the first report on the in vitro synergistic antimycobacterial effects of isoimperatorin (IO) in combination with three first-line drugs: rifampin (RMP), isoniazid (INH) and ethambutol (EMB). The results indicated that the antimycobacterial activity of IO was modest; however, IO was a useful and effective agent against Myco. tuberculosis when it was combined with first-line antimycobacterial drugs and is worthy of further development as a lead compound for the development of novel antimycobacterial therapeutic agents.

New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cells

“…It was reported that coumarins possessed various pharmacological effects, such as imperatorin, which had the antihypertensive, antioxidant [5], anti-inflammatory [6], anti-cancer [7], anticonvulsant [8], vasodilatation [9], and anti-HIV-1 [10] activities, and the prevention on lipopolysaccharide (LPS)-induced acute lung injury [11], cerebral ischemia [12], cardiac hypertrophy and heart failure [13]. Isoimperatorin was found to have the anti-Mycobacterium tuberculosis [14] and anti-inflammatory [15] activities, as well as prevention on aflatoxin B 1 -inducible cytotoxicity [16]. Phellopterin was a partial agonist of the central benzodiazepine receptors in vitro [17] with the anti-inflammatory activity [18].…”

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

“…This compound is present in Angelica dahurica, Notopterygium incisum, Ferula lutea, Angelica pubescens, and Peucedanum praeruptorum. Isoimperatorin exhibits various pharmacological activities, including antioxidant [255,256], anti-inflammatory [257], analgesic [258], antibacterial [259,260], and anticancer properties [261,262]. Wijerathne et al reported that isoimperatorin protected against OA-induced asthma via mitigation of airway inflammation and mucus hypersecretion evidenced by the decreased IL-4, IL-5, and IL-13 production [257].…”

Detoxification and Inflammation Control—“Hanshi Zufei Decoction”, a Possible Effective Phytotherapy for Mild Cases by Coronavirus Disease 19

“…Qianghuo (Notopterygium) is widely used in anti-inflammatory, anti-oxidation, anti-arrhythmia, antibacterial, anti-cancer cell proliferation and other treatments [34] [35]. Isoimperatorin (IO), a furanocoumarin isolated from Qianghuo (Notopterygium), shows prominent activity against mycobacterium tuberculosis and nematodes [36] [37]. Furthermore, IO effectively inhibits ovalbumin-induced inflammatory cell infiltration and mucus production to relieve symptoms of asthma [38].…”