<i>In Vitro</i>
            Activities and Inoculum Effects of Cefiderocol and Aztreonam-Avibactam against Metallo-β-Lactamase-Producing
            <i>Enterobacteriaceae</i>

Huang, Yué; Chen, Pao-Yu; Chou, Pei-Chun; Wang, Jann-Tay

doi:10.1128/spectrum.00569-23

Cited by 7 publications

(1 citation statement)

References 40 publications

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“…There have been limited reports on the E. cloacae complex ST316 lineage elsewhere; one study identified nine E. hormaechei ST316 isolates encoding bla KPC-2 in the United Kingdom between 2014 and 2016 as part of a larger reference study, however, the plasmid content was not reported ( 33 ). Otherwise, eight isolates [one each from references ( 34 – 36 ), and five from reference ( 37 )] of E. hormaechei ST316 have been recently been reported to carry bla NDM-1 in Asia. Although conjugation genes were present, the narrow host range of the plasmid suggests that bla KPC persistence is likely due to the ST316 clone and not driven by the plasmid.…”

Section: Discussionmentioning

confidence: 99%

Plasmid genomic epidemiology of bla _KPC carbapenemase-producing Enterobacterales in Canada, 2010–2021

Lerminiaux,

Mitchell,

Bartoszko

et al. 2023

Antimicrob Agents Chemother

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Carbapenems are considered last-resort antibiotics for the treatment of infections caused by multidrug-resistant Enterobacterales , but carbapenem resistance due to acquisition of carbapenemase genes is a growing threat that has been reported worldwide. Klebsiella pneumoniae carbapenemase ( bla KPC ) is the most common type of carbapenemase in Canada and elsewhere; it can hydrolyze penicillins, cephalosporins, aztreonam, and carbapenems and is frequently found on mobile plasmids in the Tn 4401 transposon. This means that alongside clonal expansion, bla KPC can disseminate through plasmid- and transposon-mediated horizontal gene transfer. We applied whole genome sequencing to characterize the molecular epidemiology of 829 bla KPC carbapenemase-producing isolates collected by the Canadian Nosocomial Infection Surveillance Program from 2010 to 2021. Using a combination of short-read and long-read sequencing, we obtained 202 complete and circular bla KPC -encoding plasmids. Using MOB-suite, 10 major plasmid clusters were identified from this data set which represented 87% (175/202) of the Canadian bla KPC -encoding plasmids. We further estimated the genomic location of incomplete bla KPC -encoding contigs and predicted a plasmid cluster for 95% (603/635) of these. We identified different patterns of carbapenemase mobilization across Canada related to different plasmid clusters, including clonal transmission of IncF-type plasmids (108/829, 13%) in K. pneumoniae clonal complex 258 and novel repE(pEh60-7) plasmids (44/829, 5%) in Enterobacter hormaechei ST316, and horizontal transmission of IncL/M (142/829, 17%) and IncN-type plasmids (149/829, 18%) across multiple genera. Our findings highlight the diversity of bla KPC genomic loci and indicate that multiple, distinct plasmid clusters have contributed to bla KPC spread and persistence in Canada.

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Section: Discussionmentioning

confidence: 99%

Plasmid genomic epidemiology of bla _KPC carbapenemase-producing Enterobacterales in Canada, 2010–2021

Lerminiaux,

Mitchell,

Bartoszko

et al. 2023

Antimicrob Agents Chemother

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Global prevalence of cefiderocol non-susceptibility in Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia: a systematic review and meta-analysis

Karakonstantis,

Rousaki,

Vassilopoulou

et al. 2024

Clinical Microbiology and Infection

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Evaluation of the synergistic effect of eravacycline and tigecycline against carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae

Huang,

Yang,

Wang

et al. 2024

Journal of Infection and Public Health

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In Vitro Activities and Inoculum Effects of Cefiderocol and Aztreonam-Avibactam against Metallo-β-Lactamase-Producing Enterobacteriaceae

Abstract: The prevalence of infections caused by carbapenem-resistant Enterobacteriaceae is increasing worldwide. Currently, therapeutic options for metallo-β-lactamase (MBL)-producing Enterobacteriaceae remain limited.

Cited by 7 publications

References 40 publications

Plasmid genomic epidemiology of bla _KPC carbapenemase-producing Enterobacterales in Canada, 2010–2021

Plasmid genomic epidemiology of bla _KPC carbapenemase-producing Enterobacterales in Canada, 2010–2021

Global prevalence of cefiderocol non-susceptibility in Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia: a systematic review and meta-analysis

Evaluation of the synergistic effect of eravacycline and tigecycline against carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae

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In Vitro Activities and Inoculum Effects of Cefiderocol and Aztreonam-Avibactam against Metallo-β-Lactamase-Producing Enterobacteriaceae

Abstract: The prevalence of infections caused by carbapenem-resistant Enterobacteriaceae is increasing worldwide. Currently, therapeutic options for metallo-β-lactamase (MBL)-producing Enterobacteriaceae remain limited.

Cited by 7 publications

References 40 publications

Plasmid genomic epidemiology of bla KPC carbapenemase-producing Enterobacterales in Canada, 2010–2021

Plasmid genomic epidemiology of bla KPC carbapenemase-producing Enterobacterales in Canada, 2010–2021

Global prevalence of cefiderocol non-susceptibility in Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia: a systematic review and meta-analysis

Evaluation of the synergistic effect of eravacycline and tigecycline against carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae

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Plasmid genomic epidemiology of bla _KPC carbapenemase-producing Enterobacterales in Canada, 2010–2021

Plasmid genomic epidemiology of bla _KPC carbapenemase-producing Enterobacterales in Canada, 2010–2021