<i>In situ</i> spatiotemporal characterization and analysis of chemical reactions using an ATR-integrated microfluidic reactor

Srivastava, K.; Boyle, N. D.; Flaman, G. T.; Ramaswami, B.; van den Berg, A.; van der Stam, W.; Burgess, I. J.; Odijk, M.

doi:10.1039/d3lc00521f

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…Srivastava et al, proposed a custom-designed single-bounce ATR-integrated microfluidic reactor to obtain in situ time-resolved information on chemical reactions using synchrotron IR radiation. As a proof of concept, they characterized the model second-order nucleophilic substitution (S N 2) reaction of benzyl bromide (BB) and sodium azide (SA), producing benzyl azide (BA) [ 106 ].…”

Section: Spectroscopy-based Detection Techniquesmentioning

confidence: 99%

On-Chip Photonic Detection Techniques for Non-Invasive In Situ Characterizations at the Microfluidic Scale

Kurdadze,

Lamadie,

Nehme

et al. 2024

Sensors

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Microfluidics has emerged as a robust technology for diverse applications, ranging from bio-medical diagnostics to chemical analysis. Among the different characterization techniques that can be used to analyze samples at the microfluidic scale, the coupling of photonic detection techniques and on-chip configurations is particularly advantageous due to its non-invasive nature, which permits sensitive, real-time, high throughput, and rapid analyses, taking advantage of the microfluidic special environments and reduced sample volumes. Putting a special emphasis on integrated detection schemes, this review article explores the most relevant advances in the on-chip implementation of UV–vis, near-infrared, terahertz, and X-ray-based techniques for different characterizations, ranging from punctual spectroscopic or scattering-based measurements to different types of mapping/imaging. The principles of the techniques and their interest are discussed through their application to different systems.

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Section: Spectroscopy-based Detection Techniquesmentioning

confidence: 99%

On-Chip Photonic Detection Techniques for Non-Invasive In Situ Characterizations at the Microfluidic Scale

Kurdadze,

Lamadie,

Nehme

et al. 2024

Sensors

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show abstract

“…The concept behind microfluidic devices is to downsize a traditional laboratory into a miniaturized chip, incorporating various functions such as detection 1 , 2 , mixing 3 , 4 , synthesis 5 – 8 , and separation 9 – 11 at the micro- and nano-scale. These devices are extensively used in chemical analysis 12 , 13 , chemical synthesis 14 , 15 , and biomedical analysis 16 due to their speed, accuracy, and minimal reagent requirement. Efficient mixing holds significant importance in these devices, making the attainment of quick and uniform mixing with minimal fabrication complexity.…”

Section: Introductionmentioning

confidence: 99%

Optimization of passive micromixers: effects of pillar configuration and gaps on mixing efficiency

Kheirkhah Barzoki

2024

Sci Rep

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Chemical bioreactions play a significant role in many of the microfluidic devices, and their applications in biomedical science have seen substantial growth. Given that effective mixing is vital for initiating biochemical reactions in many applications, micromixers have become increasingly prevalent for high-throughput assays. In this research, a numerical study using the finite element method was conducted to examine the fluid flow and mass transfer characteristics in novel micromixers featuring an array of pillars. The study utilized two-dimensional geometries. The impact of pillar configuration on mixing performance was evaluated using concentration distribution and mixing index as key metrics. The study explores the effects of pillar array design on mixing performance and pressure drop, drawing from principles such as contraction–expansion and split-recombine. Two configurations of pillar arrays, slanted and arrowhead, are introduced, each undergoing investigation regarding parameters such as pillar diameter, gap size between pillar groups, distance between pillars, and vertical shift in pillar groups. Subsequently, optimal micromixers are identified, exhibiting mixing efficiency exceeding 99.7% at moderate Reynolds number (Re = 1), a level typically challenging for micromixers to attain high mixing efficiency. Notably, the pressure drop remains low at 1102 Pa. Furthermore, the variations in mixing index over time and across different positions along the channel are examined. Both configurations demonstrate short mixing lengths and times. At a distance of 4300 μm from the inlet, the slanted and arrowhead configurations yielded mixing indices of 97.2% and 98.9%, respectively. The micromixers could provide a mixing index of 99.5% at the channel’s end within 8 s. Additionally, both configurations exceeded 90% mixing indices by the 3 s. The combination of rapid mixing, low pressure drop, and short mixing length positions the novel micromixers as highly promising for microfluidic applications.

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Atr-Ftir Spectroscopy Imaging with Variable Angles of Incidence of Crude Oil Deposits Formed by Flocculant Flow

Shalygin

2024

Preprint

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In situ spatiotemporal characterization and analysis of chemical reactions using an ATR-integrated microfluidic reactor

Abstract: An ATR-integrated microreactor with the ability to spatiotemporally characterize an in situ monitored chemical reaction to obtain chemical and kinetic information.

Cited by 3 publications

References 41 publications

On-Chip Photonic Detection Techniques for Non-Invasive In Situ Characterizations at the Microfluidic Scale

On-Chip Photonic Detection Techniques for Non-Invasive In Situ Characterizations at the Microfluidic Scale

Optimization of passive micromixers: effects of pillar configuration and gaps on mixing efficiency

Atr-Ftir Spectroscopy Imaging with Variable Angles of Incidence of Crude Oil Deposits Formed by Flocculant Flow

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