In situ single-cell therapeutic response imaging facilitated by the TRIPODD fluorescence imaging platform
Nathan P. McMahon,
Allison Solanki,
Lei G. Wang
et al.
Abstract:Purpose: Small molecule drugs such as tyrosine kinase inhibitors (TKIs) targeting tumoral molecular dependencies have become standard of care for numerous cancer types. Notably, epidermal growth factor receptor (EGFR) TKIs (e.g., erlotinib, afatinib, osimertinib) are the current first-line treatment for non-small cell lung cancer (NSCLC) due to their improved therapeutic outcomes for EGFR mutated and overexpressing disease over traditional platinum-based chemotherapy. However, many NSCLC tumors develop resist… Show more
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