<i>In situ</i>self-assembled peptide nanofibers for cancer theranostics

Liu, Ning; Zhu, Lianghan; Li, Zhaoting; Liu, Wenlong; Sun, Minjie; Zhou, Zhanwei

doi:10.1039/d1bm00782c

Cited by 22 publications

(10 citation statements)

References 67 publications

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“…[5] The construction of an artificial extracellular matrix (AECM) in the peripheral tumor tissue is another strategy for tumor blockade therapy. [6] AECM functions as an exogenous barrier and restrains the proliferation, migration, and invasion of cancer cells. For instance, Xu's group first reported fibrous nanonet formed by a small D-peptide derivative in the pericellular space.…”

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confidence: 99%

Versatile Polymer‐Initiating Biomineralization for Tumor Blockade Therapy

et al. 2022

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dense extracellular matrix, prevent the cell-targeting therapeutic agents from penetrating deep into tumors and compromising their therapeutic effects. [1] As a fascinating non-cell-targeting strategy, the penetration-independent tumor blockade therapy obstructs the communications between the tumor and surrounding normal tissues by blocking tumor vasculature or building physical barriers. [2] Recently, vessel-targeted blockade therapy, including vascular disruption, arterial embolization, thrombosis induction, and so forth, [3] results in tumor malnutrition and accumulation of detrimental metabolites, ultimately leading to the ischemia and necrosis of central tumor region. [4] However, the viable marginal tumor tissue, cardiac ischemia, abnormal blood pressure, reversible neurologic complications, or other possible side effects have limited its clinical translation. [5] The construction of an artificial extracellular matrix (AECM) in the peripheral tumor tissue is another strategy for tumor blockade therapy. [6] AECM functions as an exogenous barrier and restrains the proliferation, migration, and invasion of cancer cells. For instance, Xu's group first reported fibrous nanonet formed by a small D-peptide derivative in the pericellular space. [7] The nanonets entrapped the secretory proteins and blocked cell Tumor blockade therapy is a promising penetration-independent antitumor modality, which effectively inhibits the exchange of nutrients, oxygen, and information between the tumor and surrounding microenvironments. However, the current blockade therapy strategies have limited antitumor efficacy due to defects of inadequate tumor obstruction, possible side effects, and short duration. For these reasons, a facilely synthesized versatile polymer 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-poly(ethylene glycol)alendronate (DSPE-PEG-ALN, DPA) is developed to initiate the formation of biomineral shell around osteosarcoma as a potent physical barrier. The DSPE moiety shares a similar chemical structure with the cytomembrane, allowing the membrane insertion of DPA. The bisphosphonic acid groups in ALN attract ions to realize biomineralization around cells. After injection in the invasive osteosarcoma tissue, DPA inserts into the cytomembrane, induces continuous mineral deposition, and ultimately builds a physical barrier around the tumor. Meanwhile, ALN in DPA alleviates bone destruction by suppressing the activity of osteoclasts. Through hindering the exchange of necessary substances, the biomineralization coating inhibits the growth of primary osteosarcoma and pulmonary metastasis simultaneously. Therefore, the multifunctional polymer-initiating blockade therapy provides a promising modality for tumor inhibition in clinics with high efficacy and negligible side effects.

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confidence: 99%

Versatile Polymer‐Initiating Biomineralization for Tumor Blockade Therapy

et al. 2022

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“…Recently, stimulus-induced in situ self-assembly of peptides resulted in improved accumulation and prolonged retention times of NFs [ 25 ]. This assembly/aggregation induced retention (AIR) effect provides the basis for biological activity of self-assembling NFs and is increasingly exploited in theranostic therapies [ 26 ].…”

Section: Methods Of Preparationmentioning

confidence: 99%

Nanofiber Carriers of Therapeutic Load: Current Trends

Jarak

Silva

Domingues

et al. 2022

IJMS

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The fast advancement in nanotechnology has prompted the improvement of numerous methods for the creation of various nanoscale composites of which nanofibers have gotten extensive consideration. Nanofibers are polymeric/composite fibers which have a nanoscale diameter. They vary in porous structure and have an extensive area. Material choice is of crucial importance for the assembly of nanofibers and their function as efficient drug and biomedicine carriers. A broad scope of active pharmaceutical ingredients can be incorporated within the nanofibers or bound to their surface. The ability to deliver small molecular drugs such as antibiotics or anticancer medications, proteins, peptides, cells, DNA and RNAs has led to the biomedical application in disease therapy and tissue engineering. Although nanofibers have shown incredible potential for drug and biomedicine applications, there are still difficulties which should be resolved before they can be utilized in clinical practice. This review intends to give an outline of the recent advances in nanofibers, contemplating the preparation methods, the therapeutic loading and release and the various therapeutic applications.

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“…Nanofibers have also become another important drug delivery tool which has been explored to deliver therapeutics from the natural and synthetic origin and also showed potential in delivering peptides. [174][175][176] As per literature, exploration of nanofiberbased delivery has been projected for topical application [177] to the treatment of glioma. [178] With a similar strategy, Zhang and team incorporated the broad-spectrum HDAC inhibitor, trichostatin A, to evaluate the HDAC inhibitory activity and induction of histone acetylation.…”

Section: Nanofibersmentioning

confidence: 99%

Current Strategies in Breast Cancer Therapy: Role of Epigenetics and Nanomedicine

Sengupta

Choudhury

Dutta

et al. 2022

Part & Part Syst Charact

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Breast cancer (BC), the most common cancer in women, is incurable due to metastatic spread to distant organs. The existence of epigenetic dysregulation has been shown to contribute to the progression and even metastasize through the transition from epithelial to mesenchymal. Behind failure strategies of conventional treatments, fruitful outcomes of epigenetic drugs have provided the hope of solid tumor management where the reversal of acquired resistance of the cancer cells is possible by epigenome regulation. Several agents have been identified to target epigenetic regulators in the cancer cells exhibiting remarkable potential against solid tumors, including BC. However, unnecessary systemic exposure, solubility issues, and unsuitability for diseased conditions using conventional delivery systems limit their use as cancer therapeutics. The progression of nanotechnology in pharmaceutical delivery has revolutionized cancer therapy, where specific, targeted and efficient delivery of epigenetic agents for alteration of cancerous conditions are ensured. In this review, a focus is made on epigenetic alteration in BC condition with the deliverable potential of the nanocarriers toward the breast tumor microenvironment for proper management. The significance of targeting and controlled release of therapeutics in the improved targeting of cancer cells is highlighted.

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In situself-assembled peptide nanofibers for cancer theranostics

Abstract: Self-assembled nanofibers hold tremendous promise for cancer theranostics owing to their in situ assembly, spatiotemporal responsiveness, and diverse bioactivity. Herein, this review summarizes recent advances of self-assembled peptide nanofibers and...

Cited by 22 publications

References 67 publications

Versatile Polymer‐Initiating Biomineralization for Tumor Blockade Therapy

Versatile Polymer‐Initiating Biomineralization for Tumor Blockade Therapy

Nanofiber Carriers of Therapeutic Load: Current Trends

Current Strategies in Breast Cancer Therapy: Role of Epigenetics and Nanomedicine

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