<i>In Situ</i> Measurement of CuO and Cu(OH)<sub>2</sub> Nanoparticle Dissolution Rates in Quiescent Freshwater Mesocosms

Vencalek, Brian E.; Laughton, Stephanie; Spielman-Sun, Eleanor; Rodrigues, Sónia; Unrine, Jason M.; Lowry, Gregory V.; Gregory, Kelvin B.

doi:10.1021/acs.estlett.6b00252

Cited by 51 publications

(56 citation statements)

References 42 publications

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“…For materials other than BaSO 4 , more complex re-speciations must be expected, e.g. Ag sulfidation, Cu oxidation 48,49 , CeO 2 re-speciation to CePO 3 needles 29 ). Reprecipitation in flow-cells has been observed frequently during dissolution testing of stone wool mineral fibers, where especially Si tends to reprecipitate as gel on the surface of the fibers [50][51][52][53] .…”

Section: Discussionmentioning

confidence: 99%

Predicting dissolution and transformation of inhaled nanoparticles in the lung using abiotic flow cells: The case of barium sulfate

Keller

Graham

Koltermann-Jülly

et al. 2020

Sci Rep

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Barium sulfate (BaSo 4) was considered to be poorly-soluble and of low toxicity, but BaSO 4 NM-220 showed a surprisingly short retention after intratracheal instillation in rat lungs, and incorporation of Ba within the bones. Here we show that static abiotic dissolution cannot rationalize this result, whereas two dynamic abiotic dissolution systems (one flow-through and one flow-by) indicated 50% dissolution after 5 to 6 days at non-saturating conditions regardless of flow orientation, which is close to the in vivo half-time of 9.6 days. Non-equilibrium conditions were thus essential to simulate in vivo biodissolution. Instead of shrinking from 32 nm to 23 nm (to match the mass loss to ions), TEM scans of particles retrieved from flow-cells showed an increase to 40 nm. Such transformation suggested either material transport through interfacial contact or Ostwald ripening at super-saturating conditions and was also observed in vivo inside macrophages by high-resolution TEM following 12 months inhalation exposure. The abiotic flow cells thus adequately predicted the overall pulmonary biopersistence of the particles that was mediated by non-equilibrium dissolution and recrystallization. The present methodology for dissolution and transformation fills a high priority gap in nanomaterial hazard assessment and is proposed for the implementation of grouping and read-across by dissolution rates. Knowledge about pulmonary retention kinetics of inhaled particles is an essential element of hazard assessment and of understanding the mechanisms by which adverse health outcomes may occur. Barium sulfate was generally assumed to be poorly-soluble and of low toxicity unless delivered at high concentrations over an extended period 1,2. However, Konduru and colleagues reported that intratracheally instilled 131 BaSO 4 NM-220 exhibited a lung retention half-time of only 9.6 days in rats and that 131 Ba was incorporated into the bones, suggesting nanoparticle dissolution and/or translocation to extrapulmonary sites 3. A subsequent 90-day inhalation study in rats with a high concentration of aerosolized BaSO 4 NM-220 (50 mg/m 3) 4 revealed no signs of lung overload and a retention half-time of 56 days, which is close to the normal range for the rat lung 4. A two-year rat inhalation study with BaSO 4 NM-220 (50 mg/m 3), however, demonstrated an increase of retained Ba in the lung during the first year of exposure, after which a steady-state was achieved 5. Since significant Ba accumulation in bone and bone marrow was also observed and, given that the measurements of Ba distribution [1-3] provide no information about its physicochemical characteristics, the complex in vivo dissolution and/or transformation of BaSO 4 secondary to inhalation exposure require more detailed investigation.

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Section: Discussionmentioning

confidence: 99%

Predicting dissolution and transformation of inhaled nanoparticles in the lung using abiotic flow cells: The case of barium sulfate

Keller

Graham

Koltermann-Jülly

et al. 2020

Sci Rep

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“…The CuNPs used in this experiment had a larger initial size than the AuNPs, showed evidence of aggregation, but also rapidly dissolved in situ in mesocosm water (dissolution half‐life time, t 1/2 ~ 8 h) and dissolved Cu 2+ was likely complexed by dissolved organic matter (Vencalek et al. ). In contrast, AuNPs were less aggregated in the water column (~10 nm) and are assumed to have low solubility under environmental conditions (Lee and Ranville ).…”

Section: Discussionmentioning

confidence: 99%

“…It was observed that after 48 h, 60% ± 8% of the CuNPs were dissolved in absence of nutrient addition and 70% ± 3% in nutrient enriched conditions (Vencalek et al. ).…”

Section: Methodsmentioning

confidence: 99%

“…The dissolution rates of the CuNPs were assessed in situ using Float-ALyzer G2 membrane dialysis devices (Spectrum Laboratories, Rancho Dominguez, California, USA) with a molecular weight cutoff of 8-10 kDa. It was observed that after 48 h, 60% AE 8% of the CuNPs were dissolved in absence of nutrient addition and 70% AE 3% in nutrient enriched conditions (Vencalek et al 2016).…”

Section: Wetland Mesocosm Setup and Experimental Designmentioning

confidence: 99%

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Engineered nanoparticles interact with nutrients to intensify eutrophication in a wetland ecosystem experiment

Simonin

Colman

Anderson

et al. 2018

Ecological Applications

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Despite the rapid rise in diversity and quantities of engineered nanomaterials produced, the impacts of these emerging contaminants on the structure and function of ecosystems have received little attention from ecologists. Moreover, little is known about how manufactured nanomaterials may interact with nutrient pollution in altering ecosystem productivity, despite the recognition that eutrophication is the primary water quality issue in freshwater ecosystems worldwide. In this study, we asked two main questions: (1) To what extent do manufactured nanoparticles affect the biomass and productivity of primary producers in wetland ecosystems? (2) How are these impacts mediated by nutrient pollution? To address these questions, we examined the impacts of a citrate-coated gold nanoparticle (AuNPs) and of a commercial pesticide containing Cu(OH) nanoparticles (CuNPs) on aquatic primary producers under both ambient and enriched nutrient conditions. Wetland mesocosms were exposed repeatedly with low concentrations of nanoparticles and nutrients over the course of a 9-month experiment in an effort to replicate realistic field exposure scenarios. In the absence of nutrient enrichment, there were no persistent effects of AuNPs or CuNPs on primary producers or ecosystem productivity. However, when combined with nutrient enrichment, both NPs intensified eutrophication. When either of these NPs were added in combination with nutrients, algal blooms persisted for >50 d longer than in the nutrient-only treatment. In the AuNP treatment, this shift from clear waters to turbid waters led to large declines in both macrophyte growth and rates of ecosystem gross primary productivity (average reduction of 52% ± 6% and 92% ± 5%, respectively) during the summer. Our results suggest that nutrient status greatly influences the ecosystem-scale impact of two emerging contaminants and that synthetic chemicals may be playing an under-appreciated role in the global trends of increasing eutrophication. We provide evidence here that chronic exposure to Au and Cu(OH) nanoparticles at low concentrations can intensify eutrophication of wetlands and promote the occurrence of algal blooms.

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“…The high demand and application of CuO NPs will likely increase their release into the environment, but the environmental behavior of CuO NPs has not yet been well characterized. For example, most previous studies determined the dissolved Cu percentage after a specific time; however, the NP concentration supersaturated with CuO varied by several orders of magnitude (0.025–60%) . And only a few studies reported the dissolution rates of CuO NPs .…”

Section: Environmental Behavior Of Cuo Nps and Asmentioning

confidence: 99%

Environmental behavior, potential phytotoxicity, and accumulation of copper oxide nanoparticles and arsenic in rice plants

Liu¹,

Dhungana²,

Cobb³

2017

Enviro Toxic and Chemistry

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Copper oxide nanoparticles (CuO NPs) are widely used in many industries. The increasing release of CuO NPs from both intentional and unintentional sources into the environment may pose risks to rice plants, thereby reducing the quality or quantity of this staple grain in the human diet. Not only has arsenic (As) contamination decreased rice yield, but As accumulation in rice has also been a great human health concern for a few decades. New technologies have succeeded in removing As from water by nanomaterials. By all accounts, few studies have addressed CuO NP phytotoxicity to rice, and the interactions of CuO NPs with As are poorly described. The present study 1) reviews studies about the environmental behavior and phytotoxicity of CuO NPs and As and research about the interaction of CuO NPs with As in the environment, 2) discusses critically the potential mechanisms of CuO NP and As toxicity in plants and their interaction, and 3) proposes future research directions for solving the As problem in rice. Environ Toxicol Chem 2018;37:11-20. C 2017 SETAC

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In Situ Measurement of CuO and Cu(OH)₂ Nanoparticle Dissolution Rates in Quiescent Freshwater Mesocosms

Cited by 51 publications

References 42 publications

Predicting dissolution and transformation of inhaled nanoparticles in the lung using abiotic flow cells: The case of barium sulfate

Predicting dissolution and transformation of inhaled nanoparticles in the lung using abiotic flow cells: The case of barium sulfate

Engineered nanoparticles interact with nutrients to intensify eutrophication in a wetland ecosystem experiment

Environmental behavior, potential phytotoxicity, and accumulation of copper oxide nanoparticles and arsenic in rice plants

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In Situ Measurement of CuO and Cu(OH)2 Nanoparticle Dissolution Rates in Quiescent Freshwater Mesocosms

Cited by 51 publications

References 42 publications

Predicting dissolution and transformation of inhaled nanoparticles in the lung using abiotic flow cells: The case of barium sulfate

Predicting dissolution and transformation of inhaled nanoparticles in the lung using abiotic flow cells: The case of barium sulfate

Engineered nanoparticles interact with nutrients to intensify eutrophication in a wetland ecosystem experiment

Environmental behavior, potential phytotoxicity, and accumulation of copper oxide nanoparticles and arsenic in rice plants

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Product

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In Situ Measurement of CuO and Cu(OH)₂ Nanoparticle Dissolution Rates in Quiescent Freshwater Mesocosms