<i>In situ</i> injection of dual-delivery PEG based MMP-2 sensitive hydrogels for enhanced tumor penetration and chemo-immune combination therapy

Yan, Jianqin; Zhang, Zhuangzhuang; Zhan, Xiaowei; Chen, Keqi; Pu, Yuji; Liang, Yan; He, Bin

doi:10.1039/d1nr01155c

Cited by 44 publications

(23 citation statements)

References 39 publications

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“…These results confirmed that the NB can enhance the therapeutic effect of CDT by the cellular redox homeostasis interference because of the NB with good biocompatibility when the concentration is lesser than 500 μg ml −1 (Supplementary Figure S6). Finally, the antitumor effect of NB/CuS@PCM NPs is also verified by PI staining (Yan et al, 2021). And the result was consistent with the MTT assay (Figure 3D, PI staining).…”

Section: Resultssupporting

confidence: 84%

An NIR-II Responsive Nanoplatform for Cancer Photothermal and Oxidative Stress Therapy

Huang

Han

et al. 2021

Front. Bioeng. Biotechnol.

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Chemodynamic therapy as an emerging therapeutic strategy has been implemented for oncotherapy. However, the reactive oxygen species can be counteracted by the exorbitant glutathione (GSH) produced by the tumor cells before exerting the antitumor effect. Herein, borneol (NB) serving as a monoterpenoid sensitizer, and copper sulfide (CuS NPs) as an NIR-II photothermal agent were loaded in a thermo-responsive vehicle (NB/CuS@PCM NPs). Under 1,060-nm laser irradiation, the hyperthermia produced by CuS NPs can be used for photothermal therapy and melt the phase change material for drug delivery. In the acidity microenvironment, the CuS NPs released from NB/CuS@PCM NPs could degrade to Cu2+, then Cu2+ was reduced to Cu+ during the depletion of GSH. As Fenton-like catalyst, the copper ion could convert hydrogen peroxide into hydroxyl radicals for chemodynamic therapy. Moreover, the NB originated from NB/CuS@PCM NPs could increase the intracellular ROS content to improve the treatment outcome of chemodynamic therapy. The animal experimental results indicated that the NB/CuS@PCM NPs could accumulate at the tumor site and exhibit an excellent antitumor effect. This work confirmed that the combination of oxidative stress–induced damage and photothermal therapy is a potential therapeutic strategy for cancer treatment.

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Section: Resultssupporting

confidence: 84%

An NIR-II Responsive Nanoplatform for Cancer Photothermal and Oxidative Stress Therapy

Huang

Han

et al. 2021

Front. Bioeng. Biotechnol.

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“…The Michael addition reaction is also utilized in drug delivery and the releasing of on-demand materials [ 106 ]. According to Guo et al, Diacrylate modified 8-arm PEG was crosslinked with MMP-sensitive peptide (CGPQG↓IWGQC) via the Michael addition reaction [ 107 ].…”

Section: Synthesis Of Mmp-cleavable Peptides-based Hydrogelsmentioning

confidence: 99%

Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels

Chen

Zhou

Chen

et al. 2021

Gels

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Accumulating evidence has suggested the significant potential of chemically modified hydrogels in bone regeneration. Despite the progress of bioactive hydrogels with different materials, structures and loading cargoes, the desires from clinical applications have not been fully validated. Multiple biological behaviors are orchestrated precisely during the bone regeneration process, including bone marrow mesenchymal stem cells (BMSCs) recruitment, osteogenic differentiation, matrix calcification and well-organized remodeling. Since matrix metalloproteinases play critical roles in such bone metabolism processes as BMSC commitment, osteoblast survival, osteoclast activation matrix calcification and microstructure remodeling, matrix metalloproteinase (MMP) cleavable peptides-based hydrogels could respond to various MMP levels and, thus, accelerate bone regeneration. In this review, we focused on the MMP-cleavable peptides, polymers, functional modification and crosslinked reactions. Applications, perspectives and limitations of MMP-cleavable peptides-based hydrogels for bone regeneration were then discussed.

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“…Like “Domino-effect”, the chemotherapy combined with immunotherapy could amplify the efficacy of anti-tumor treatment. Studies have demonstrated that many advanced nanoparticles are competent to break through barriers in combinatorial chemo-immune treatment ( Wei X. et al, 2019 ; He et al, 2021 ; Yan et al, 2021 ). Notably, the latest study reveals the phenomenon that some nanomaterials possess the inherent biological effect on immunotherapy.…”

Section: Nanomaterials Therapeutics Overcome Drug Resistancementioning

confidence: 99%

Emerging Nano-Based Strategies Against Drug Resistance in Tumor Chemotherapy

Cao¹,

Zhu²,

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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Drug resistance is the most significant causes of cancer chemotherapy failure. Various mechanisms of drug resistance include tumor heterogeneity, tumor microenvironment, changes at cellular levels, genetic factors, and other mechanisms. In recent years, more attention has been paid to tumor resistance mechanisms and countermeasures. Nanomedicine is an emerging treatment platform, focusing on alternative drug delivery and improved therapeutic effectiveness while reducing side effects on normal tissues. Here, we reviewed the principal forms of drug resistance and the new possibilities that nanomaterials offer for overcoming these therapeutic barriers. Novel nanomaterials based on tumor types are an excellent modality to equalize drug resistance that enables gain more rational and flexible drug selectivity for individual patient treatment. With the emergence of advanced designs and alternative drug delivery strategies with different nanomaterials, overcome of multidrug resistance shows promising and opens new horizons for cancer therapy. This review discussed different mechanisms of drug resistance and recent advances in nanotechnology-based therapeutic strategies to improve the sensitivity and effectiveness of chemotherapeutic drugs, aiming to show the advantages of nanomaterials in overcoming of drug resistance for tumor chemotherapy, which could accelerate the development of personalized medicine.

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In situ injection of dual-delivery PEG based MMP-2 sensitive hydrogels for enhanced tumor penetration and chemo-immune combination therapy

Abstract: Improving the deep penetration of nanoparticles and realizing the combination of chemotherapy and immunotherapy have become a promising strategy for cancer treatment.

Cited by 44 publications

References 39 publications

An NIR-II Responsive Nanoplatform for Cancer Photothermal and Oxidative Stress Therapy

An NIR-II Responsive Nanoplatform for Cancer Photothermal and Oxidative Stress Therapy

Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels

Emerging Nano-Based Strategies Against Drug Resistance in Tumor Chemotherapy

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