In situ Growth of Ni(OH)₂ Nanoparticles on 316L Stainless Steel Foam: An Efficient Three‐dimensional Non‐enzymatic Glucose Electrochemical Sensor in Real Human Blood Serum Samples

Abstract

For the first time, nickel hydroxide nanoparticles (Ni(OH) 2 NPs) grown on 316L stainless steel foam were used as a non-enzymatic electrochemical glucose sensor. The Ni(OH) 2 /SSF-316L was elaborated by applying a simple ultrafast CV method without nickel salts addition. Ni(OH) 2 /SSF-316L was characterized by SEM and XRD. The electrochemical behavior was investigated by CV, EIS, and amperometric measurements. The fabricated sensor revealed higher sensitivity 1062 μA mM À 1 cm À 2 , wide linear range from 1.0 μM to 4.0 mM with a low detection limit of 2.0 μM and good selectivity. In addition, real sample analysis was performed for controlled glucose in real blood serum.

Recent Advances in Materials for Enzyme-free Electrochemical Glucose Sensors

“…(3,4) Moreover, the difficulty in fixing GOx and its high cost also limit its application. (5) Therefore, enzyme-free glucose sensors, which do not use any biological enzymes, have caught people's interests owing to their high stability, good reproducibility, ability to be manufactured in mass, and easy miniaturization. (6)(7)(8)(9)(10) Enzyme-free glucose sensors use sensitive nanomaterials directly loaded on the electrode surface to catalyze the reactions of glucose and can overcome the traditional dependence on enzyme activity.…”