<i>In situ</i> forming, mechanically resilient hydrogels prepared from 4a-[PEG-<i>b</i>-PTMC-Ac] and thiolated chondroitin sulfate for nucleus pulposus cell delivery

Riahinezhad, Hossein; Amsden, Brian G.

doi:10.1039/d3tb02574h

J. Mater. Chem. B

2024

DOI: 10.1039/d3tb02574h

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In situ forming, mechanically resilient hydrogels prepared from 4a-[PEG-b-PTMC-Ac] and thiolated chondroitin sulfate for nucleus pulposus cell delivery

Hossein Riahinezhad,

Brian G. Amsden

Abstract: Intervertebral disk degeneration (IVDD) is a common condition that causes severe back pain and affects patients’ mobility and life quality considerably. IVDD originates within the central region of the disk...

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Cutting-Edge Biomaterials in Intervertebral Disc Degeneration Tissue Engineering

Wang,

Zhang,

Cheng

et al. 2024

Pharmaceutics

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Intervertebral disc degeneration (IVDD) stands as the foremost contributor to low back pain (LBP), imposing a substantial weight on the world economy. Traditional treatment modalities encompass both conservative approaches and surgical interventions; however, the former falls short in halting IVDD progression, while the latter carries inherent risks. Hence, the quest for an efficacious method to reverse IVDD onset is paramount. Biomaterial delivery systems, exemplified by hydrogels, microspheres, and microneedles, renowned for their exceptional biocompatibility, biodegradability, biological efficacy, and mechanical attributes, have found widespread application in bone, cartilage, and various tissue engineering endeavors. Consequently, IVD tissue engineering has emerged as a burgeoning field of interest. This paper succinctly introduces the intervertebral disc (IVD) structure and the pathophysiology of IVDD, meticulously classifies biomaterials for IVD repair, and reviews recent advances in the field. Particularly, the strengths and weaknesses of biomaterials in IVD tissue engineering are emphasized, and potential avenues for future research are suggested.

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Cutting-Edge Biomaterials in Intervertebral Disc Degeneration Tissue Engineering

Wang,

Zhang,

Cheng

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

show abstract

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In situ forming, mechanically resilient hydrogels prepared from 4a-[PEG-b-PTMC-Ac] and thiolated chondroitin sulfate for nucleus pulposus cell delivery

Abstract: Intervertebral disk degeneration (IVDD) is a common condition that causes severe back pain and affects patients’ mobility and life quality considerably. IVDD originates within the central region of the disk...

Cited by 1 publication

References 67 publications

Cutting-Edge Biomaterials in Intervertebral Disc Degeneration Tissue Engineering

Cutting-Edge Biomaterials in Intervertebral Disc Degeneration Tissue Engineering

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