In situ forming double-crosslinked hydrogels with highly dispersed short fibers for the treatment of irregular wounds

Abstract

The in-situ forming injectable hydrogels hold great potential for the treatment of irregular wounds. However, their practical applications were hindered by long gelation time, poor mechanical performance, and lack of...

Electroactive nanofibrous membrane with temperature monitoring for wound healing

“…Severe inammatory response and inltration of inammatory cells can delay wound healing. 53,54 The wound site skin was taken for HE staining on days 6 and 9 to observe the inammatory cell inltration (Fig. 7a and c).…”

Methylcellulose/agarose hydrogel loaded with short electrospun PLLA/laminin fibers as an injectable scaffold for tissue engineering/3D cell culture model for tumour therapies

“…The such minimally invasive solution increases potential patients' comfort and faster convalescence. 33,34…”

“…The such minimally invasive solution increases potential patients' comfort and faster convalescence. 33,34 Electrospun-oriented PLLA bers are widely used as scaffolds for neural tissue regeneration, mainly due to their biocompatibility, controlled degradation, and mechanical properties similar to neural tissue. The brous structure effectively supports the regeneration of neurons in both in vitro and in vivo conditions.…”

Gelatin-Based Injectable Hydrogels Loaded with Copper Ion Cross-linked Tannic Acid Nanoparticles for Irregular Wound Closure Repair

“…The resulting injectable hydrogel exhibits good biocompatibility and cellular infiltration while actively promoting wound healing. However, it should be noted that the mechanical properties and adhesion to wounds of this hydrogel are relatively poor . It is worth noting that most injectable hydrogels usually suffer from several problems: (1) They have poor biocompatibility of the reactive monomer and initiator, which is not conducive to wound repair.…”

“…However, it should be noted that the mechanical properties and adhesion to wounds of this hydrogel are relatively poor. 32 It is worth noting that most injectable hydrogels usually suffer from several problems: (1) They have poor biocompatibility of the reactive monomer and initiator, which is not conducive to wound repair. (2) The initiation efficiency of the initiator is not enough, and the speed of its in situ molding is not enough.…”