Abstract:Peroxisome proliferator ‐activated receptors (PPAR) are nuclear receptors which regulate gene expression, mainly in the metabolism of lipids and carbohydrates. The γ isotype has as exogenous ligands the thiazolidinediones (TZD), which are used for the treatment of type 2 diabetes mellitus (DM2), though, drugs from this group have been shown to produce severe adverse effects such as hepatic steatosis and massive weight gain. Since this, the aim of this work is to design a new set of molecules based on the substi… Show more
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