<i>In silico</i>analysis of<i>Bacopa monnieri</i>(L.) Wettst. compounds for drug development against Neurodegenerative Disorders

Sangeet, Satyam; Khan, Arshad; Mahanta, Saurov; Roy, Nabamita Banerjee; Das, Sanjib Kumar; Mohanta, Yugal Kishore; Saravanan, Muthupandian; Tag, Hui; Hui, Pallabi K.

doi:10.1101/2022.03.30.486025

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…B. monniera is used for memory enhancement, stress relief for nervousness, and wisdom. The main bioactive ingredients of B. monniera are bacosides, bacopa saponins, betulinic acid, and stigmastanol that help to repair impede neurons, restore synaptic activity, conduct nerve impulse, and kinase activity (Sangeet et al, 2022).…”

Section: Bacopa Monnieramentioning

confidence: 99%

Prominent Medicinal Plants for the Treatment of Neurodegenerative Disorders

Sajid,

Abbas,

Khan

et al. 2023

Complementary and Alternative Medicine: One Health Perspective

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The phrase "neurodegenerative diseases" refers to conditions that cause a major loss of neurons, both structurally and functionally. Neurodegenerative diseases are serious life-threatening in which neural cells in the brain stop working or die. One of the most recently discovered pathogenic processes in the genesis of neurological illnesses is mitochondrial dysfunction. Mitochondria play a significant role in various cellular processes such as the production of ATP, intracellular calcium, and generation of reactive oxygen species and improper function leads to diseases. Oxidative stress and aging are two other prevalent etiologies of neurological diseases. Several side effects have emerged as a result of current treatment methods and the progressive nature of illnesses, prompting patients to switch to other medications. The helpful impact of medicinal plants in these situations has been attributed to their demonstration through several cellular and molecular processes. Traditional plants have a few neuroprotective mechanisms: they reduce inflammatory responses, regulate pro-inflammatory cytokines' functional aspects such as tumor growth, and enhance antioxidant qualities. Plant prevention strategies for these diseases heavily rely on variations in transcription and transduction pathways. Some of the therapeutic herbs for preventing neurological disorders are Panax ginseng, Curcuma longa, Zingiber officinale, Ginkgo biloba, and Utrica diocia, etc., have shown antioxidant as well as anti-inflammatory effects and also show a promising tool for treating neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, multiple sclerosis, and epilepsy. Medicinal plants contain various phytochemical constituents that improve oxidative stress, reduce mitochondrial damage, and protect against brain damage. In short, use of whole plants or parts of medicinal plants from roots to seeds extracted chemicals are used to prevent neurodegenerative illnesses.

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Section: Bacopa Monnieramentioning

confidence: 99%

Prominent Medicinal Plants for the Treatment of Neurodegenerative Disorders

Sajid,

Abbas,

Khan

et al. 2023

Complementary and Alternative Medicine: One Health Perspective

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An in-silico approach to identify bioactive phytochemicals fromHouttuynia cordataThunb. As potential inhibitors of Human Glutathione Reductase

Sangeet,

Khan

2023

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Cellular infections underpin the pathogenesis of cancer and malaria. Mitigating cellular oxidative stress via glutathione reductase (GR) inhibition emerges as a promising therapeutic avenue. Exploiting the antioxidant-rich Houttuynia cordata Thunb., we investigated natural GR inhibitors. Among 13 docked phytochemicals, Quercetin, Quercitrin, and Sesamin exhibited exceptional GR binding affinities. Molecular Docking analysis highlighted their propensity to precisely target the GR active site. Subsequent 150 ns molecular dynamics simulations corroborated their robust interactions, unveiling dynamic stabilizing effects on the protein structure and bolstering their antioxidant potential. Furthermore, ADME-Tox profiling affirmed their favourable drug-like attributes. These findings underscore H. cordata's reservoir of potent antioxidants, poised to combat various maladies, including malaria and cancer. This study distinctly accentuates the distinctive outcomes and paramount significance of harnessing H. cordata phytochemicals as efficacious antioxidants, unravelling novel therapeutic avenues.

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In silicoanalysis ofBacopa monnieri(L.) Wettst. compounds for drug development against Neurodegenerative Disorders

Cited by 2 publications

References 48 publications

Prominent Medicinal Plants for the Treatment of Neurodegenerative Disorders

Prominent Medicinal Plants for the Treatment of Neurodegenerative Disorders

An in-silico approach to identify bioactive phytochemicals fromHouttuynia cordataThunb. As potential inhibitors of Human Glutathione Reductase

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