IL-10 and PRKDC polymorphisms are associated with glioma patient survival

Abstract

Interleukin-10 (IL-10) and DNA repair gene PRKDC mutations are implicated in the development of multiple human cancers, including glioma. We investigated associations between IL-10 and PRKDC gene polymorphisms and prognosis in lowand high-grade glioma patients. We analyzed the associations of one IL-10 and one PRKDC single nucleotide polymorphism with patient clinical factors in 481 glioma patients using Cox proportional hazard models and Kaplan-Meier curves. We also assessed associations between patient clinical characteristics and prognosis. Our data showed that the extent of tumor resection (gross-total resection) and application of chemotherapy were associated with improved patient outcomes in all glioma cases. Additionally, univariate (Log-rank p = 0.019) and multivariate Cox regression analyses (p = 0.022) showed that the IL-10 rs1800871 C/T genotype correlates with improved overall survival in cases of low-grade glioma, whereas the PRKDC rs7003908 C/C genotype correlated with reduced overall and progression-free survival in high-grade glioma patients in univariate (Log-rank p = 0.000 and p = 0.000, respectively) and multivariate Cox regression analyses (p = 0.001; p = 0.002, respectively). These results suggest that IL-10 rs1800871 and PRKDC rs7003908 may be useful biomarkers for predicting glioma patient outcome. Further functional studies are needed to evaluate the mechanisms by which these polymorphisms affect glioma progression.

IL-10 Gene Rs1800871, Rs1800872, and Rs1800896 Polymorphisms and IL-10 Serum Levels Association with Pituitary Adenoma

“…The study found that a high expression of IL-10 was strongly associated with poor survival [ 42 ]. Therefore, a study by Guo et al suggest that IL-10 rs1800871 may be a useful biomarker for predicting glioma patient outcomes [ 43 ]. Another study showed that patients with primary central nervous system lymphomas (PCNSLs) and primary vitreoretinal lymphomas (PVRLs) had similar IL-10 (-1082) A allele frequencies, but their genotype distributions differed from those of the healthy controls.…”

Identification of an Individualized Prognostic Signature Based on the RWSR Model in Early-Stage Bladder Carcinoma

“…A previous study has implicated that downregulation of PRKDC-sensitized MCF-7 cells to chemodrugs in vitro, which is a potential prognostic and predictive marker of response to adjuvant chemotherapy in breast cancer patients [63]. It is proved that PRKDC expression is significantly increased in breast cancer tissue samples compared with NATs and is correlated with reduced overall and progression-free survival in highgrade glioma patients [64]. Downregulation of PRKDC reduces colorectal cancer cell proliferation/survival and induces apoptosis partially through inhibiting AKT activation in colorectal cancer cells.…”