<i>IGF1</i>gene polymorphisms associated with diabetic retinopathy risk in Chinese Han population

Zhang, Jian; Xiao, Chen; Zhang, Like; Peng, Yi

doi:10.18632/oncotarget.21366

Cited by 14 publications

(15 citation statements)

References 27 publications

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“…Dotta et al reported that the rs35767GG genotype exhibited circulating concentrations of IGF1 and lower insulin sensitivity in Europeans [11]. However, Zhang et al found that the A allele of rs35767 contributed to the risk of developing T2DM in a Chinese Han population [25]. Presently, we did not find evidence of an association between rs35767 and T2DM.…”

Section: Discussioncontrasting

confidence: 87%

“…In addition to the indirect role of JAZF1, IGF1, and IGF2BP2 in insulin resistance involving lipid metabolism, the three proteins can also have direct effects on glucose metabolism [5,16,19]. The genes encoding these proteins, as well as their SNPs, have been associated with T2DM and metabolic traits [6,11,[20][21][22][23][24][25][26]. For example, Long et al reported that rs6769511C in IGF2BP2 was associated with the risk of T2DM in African Americans [22].…”

Section: Ivyspringmentioning

confidence: 99%

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Evidence of association between single-nucleotide polymorphisms in lipid metabolism-related genes and type 2 diabetes mellitus in a Chinese population

et al. 2021

Int. J. Med. Sci.

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Background: Type 2 diabetes mellitus (T2DM) is a complex chronic metabolic disorder triggered by insulin resistance in peripheral tissues. Evidence has shown that lipid metabolism and related genetic factors lead to insulin resistance. Hence, it is meaningful to investigate the association between single-nucleotide polymorphisms (SNPs) in lipid metabolism-related genes and T2DM. Methods: A total of 1,194 subjects with T2DM and 1,274 Non-diabetic subjects (NDM) were enrolled. Five SNPs in three genes (rs864745 in JAZF1 , rs35767 in IGF1 , and rs4376068, rs4402960, and rs6769511 in IGF2BP2 ) that contribute to insulin resistance involving lipid metabolism were genotyped using the MassArray method in a Chinese population. Results: The allele and genotypes of rs6769511 in IGF2BP2 were associated with T2DM (P=0.009 and P=0.002, respectively). In inheritance model analysis, compared with the T/T-C/T genotype, the C/C genotype of rs6769511 in IGF2BP2 was a risk factor for the development of T2DM (P<0.001, odds ratio [OR] =1.76; 95% confidence interval [CI]: 1.29-2.42). Haplotype analysis revealed associations of the rs4376068-rs4402960-rs6769511 haplotypes in IGF2BP2 with the development of T2DM (P=0.015). Additionally, rs4376068C-rs4402960T-rs6769511C was a risk haplotype for T2DM (OR=1.179; 95% CI: 1.033-1.346). Conclusion: The rs6769511 in IGF2BP2 was associated with T2DM susceptibility, and the rs4376068-rs4402960-rs6769511 haplotypes in IGF2BP2 was associated with the development of T2DM in a Chinese population.

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Section: Discussioncontrasting

confidence: 87%

Section: Ivyspringmentioning

confidence: 99%

Evidence of association between single-nucleotide polymorphisms in lipid metabolism-related genes and type 2 diabetes mellitus in a Chinese population

et al. 2021

Int. J. Med. Sci.

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“…[25] According to existing documents, there are some functional polymorphisms in IGF-1 gene which could influence the transcriptional activity and protein production, like rs35767, rs5742714, and rs972936. [19–21] Moreover, a series of studies have demonstrated that these three polymorphisms were involved in various human diseases. For instance, Marini et al reported that the individuals carrying rs35767 T allele showed low risk of anemia compared with C allele.…”

Section: Discussionmentioning

confidence: 99%

“…For example, Zhang et al suggested that IGF1 rs35767 polymorphism might contribute to the risk of diabetic retinopathy through regulating serum concentration of IGF1 in Chinese Han population. [19] Cao et al reported that the genetic variants of rs5742714 polymorphism showed obvious association with IGF1 serum level, moreover, rs5742714 may be a genetic predictor of susceptibility and prognosis for renal cell carcinoma among Chinese Han population. [20] Rs972936 also holds the capacity to regulate human diseases via influencing circulating levels of IGF-1 .…”

Section: Introductionmentioning

confidence: 99%

IGF-1 polymorphisms modulate the susceptibility to osteonecrosis of the femoral head among Chinese Han population

2019

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The study was performed to investigate the genetic associations of IGF-1 polymorphisms rs35767, rs5742714, and rs972936 with susceptibility to osteonecrosis of the femoral head (ONFH) among Chinese Han population. Totally, 101 ONFH patients and 128 healthy controls were enrolled. Hardy–Weinberg equilibrium (HWE) was detected with chi-square test in control group. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to estimate the relationship between IGF-1 polymorphisms and ONFH risk. Besides, hyplotype analysis was performed to examine linkage disequilibrium between the studied polymorphisms. Genotype AA and allele A of polymorphism rs35767 were more frequent in control group, and offered protection for ONFH onset (AA: OR = 0.382, 95% CI = 0.158-0.923; A: OR = 0.650, 95% CI = 0.442–0.956). Furthermore, the negative relationship was also observed between ONFH risk and polymorphism rs5742714 under the comparisons CG vs CC, and G vs C (OR = 0.395, 95%CI = 0.199–0.787; OR = 0.346, 95%CI = 0.191–0.627). While the polymorphism rs972936 significantly enhanced the disease risk (CT vs CC: OR = 2.434, 95% CI = 1.184–5.003; TT vs CC: OR = 2.497, 95% CI = 1.040–5.990). Furthermore, haplotype analysis demonstrated that C-T (rs5742714–rs972936) could increase ONFH risk (OR = 2.177, 95% CI = 1.444–3.283), while G-T might be a protective factor for ONFH (OR = 0.472, 95% CI = 0.254–0.878). IGF-1 polymorphisms rs35767, rs5742714, and rs972936 show significant association with ONFH risk.

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“…The SNP rs35767 is known to contribute to the development of diabetes in various population. A study showed TT genotype of rs35767 increased 1.92 fold and 1.77 fold of risk for T2DM and diabetic retinopathy in the Chinese Han population, respectively [21]. Besides, CC genotype of rs7136446 had higher body mass index and body fat percentage than TT and CT genotypes [22] but lacking evidence on other metabolic traits [23].…”

mentioning

confidence: 99%

Dietary Acid Load and Its Interaction With IGF1 and IL6 Polymorphisms on Metabolic Traits Among Postmenopausal Women

Lim¹,

Chan²,

Ramachandran³

et al. 2020

Preprint

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Background: Despite considerable work has been done to understand the underlying disease mechanisms by elucidating its genetic etiology, still the pathophysiology of the metabolic syndrome remains unclear. While numerous studies have shown that Insulin growth factors-1 (IGF1), Interleukin-6 (IL-6) gene polymorphisms and high dietary acid load (DAL) were related to undesirable profile of metabolic traits; it remains controversial whether DAL is associated with genetic polymorphisms or risk of metabolic traits. Thus, the objective of this study was to explore the effects of DAL, IGF1 and IL6 gene polymorphisms and their potential diet-gene interactions on metabolic traits. Methods: A total of 211 community-dwelling postmenopausal women were recruited. DAL was estimated using potential renal acid load (PRAL). Blood was drawn for biochemical parameters and DNA was extracted and Agena® MassARRAY was used for genotyping analysis to identify the signaling of IGF1 (rs35767, rs7136446) and IL6 (rs1800796) polymorphisms. Interactions between diet and genetic polymorphisms were assessed using hierarchical multiple linear regression analysis.Results: Mean age of respondents was 67 ± 6.7 years. A total of 68.2%, 59.2%, 49.3%, 23.2%, 23.2% and 10.9% had elevated systolic blood pressure (SBP), hyperglycemia, excessive waist circumference (WC), diastolic blood pressure (DBP), triglycerides (TG) and low high-density lipoprotein (HDL), respectively. DAL was positively associated with FBG (β = 0.147, p < 0.05) and there was significant interaction effect between DAL and IL6 with SBP (β = 0.19, p = 0.041). On the other hand, there were no significant main effects of DAL and single nucleotide polymorphisms (SNPs) (rs35767, rs7136446 and rs1800796) on SBP, DBP, WC, TG or HDL and cholesterol ratio. There were also no significant interaction effects between DAL and IGF1 SNPs (rs35767 and rs7136446) on SBP, DBP and FBG, TG, HDL and cholesterol ratio. Conclusion: These findings did not support the interaction effects between DAL and IGF1 and IL6 SNPs (s35767, rs7136446 and rs1800796) on metabolic traits, except for SBP. Besides, higher DAL was associated with higher FBG, allowing us to postulate high DAL is a potential risk factor for diabetes. Future research delineating foods that contribute to high DAL, and how IL6 gene polymorphism influences the association with DAL on hypertension are warranted.

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IGF1gene polymorphisms associated with diabetic retinopathy risk in Chinese Han population

Cited by 14 publications

References 27 publications

Evidence of association between single-nucleotide polymorphisms in lipid metabolism-related genes and type 2 diabetes mellitus in a Chinese population

Evidence of association between single-nucleotide polymorphisms in lipid metabolism-related genes and type 2 diabetes mellitus in a Chinese population

IGF-1 polymorphisms modulate the susceptibility to osteonecrosis of the femoral head among Chinese Han population

Dietary Acid Load and Its Interaction With IGF1 and IL6 Polymorphisms on Metabolic Traits Among Postmenopausal Women

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