Candida albicansandEnterococcus faecalisin the gut

Garsin, Danielle A.; Lorenz, Michael

doi:10.4161/gmic.26040

Cited by 50 publications

(34 citation statements)

References 52 publications

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“…These findings, together with the recent reports of the commensalism between C. albicans and E. faecalis in the mouse gut46 suggest that through mutual inhibition of virulence, C. albican s and its interacting bacterial counterparts trade their pathogenicity for long-term fitness, thus facilitating a commensal existence within the host.…”

Section: Discussionmentioning

confidence: 61%

Morphological and physiological changes induced by contact-dependent interaction between Candida albicans and Fusobacterium nucleatum

Bor

Cen

Agnello

et al. 2016

Sci Rep

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Candida albicans and Fusobacterium nucleatum are well-studied oral commensal microbes with pathogenic potential that are involved in various oral polymicrobial infectious diseases. Recently, we demonstrated that F. nucleatum ATCC 23726 coaggregates with C. albicans SN152, a process mainly mediated by fusobacterial membrane protein RadD and Candida cell wall protein Flo9. The aim of this study was to investigate the potential biological impact of this inter-kingdom interaction. We found that F. nucleatum ATCC 23726 inhibits growth and hyphal morphogenesis of C. albicans SN152 in a contact-dependent manner. Further analysis revealed that the inhibition of Candida hyphal morphogenesis is mediated via RadD and Flo9 protein pair. Using a murine macrophage cell line, we showed that the F. nucleatum-induced inhibition of Candida hyphal morphogenesis promotes C. albicans survival and negatively impacts the macrophage-killing capability of C. albicans. Furthermore, the yeast form of C. albicans repressed F. nucleatum-induced MCP-1 and TNFα production in macrophages. Our study suggests that the interaction between C. albicans and F. nucleatum leads to a mutual attenuation of virulence, which may function to promote a long-term commensal lifestyle within the oral cavity. This finding has significant implications for our understanding of inter-kingdom interaction and may impact clinical treatment strategies.

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Section: Discussionmentioning

confidence: 61%

Morphological and physiological changes induced by contact-dependent interaction between Candida albicans and Fusobacterium nucleatum

Bor

Cen

Agnello

et al. 2016

Sci Rep

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“…Interestingly, within the intact gut of the worm, Candida albicans and Enterococcus faecalis show a symbiotic relationship, concurrently reducing the pathogenicity of the other. In the absence of E. faecalis , C. albicans showed an increased hyphal morphogenesis, a key virulence factor . This type of relationship is not limited to the GIT.…”

Section: The Role Of the Intestinal Microbiomementioning

confidence: 88%

The triune of intestinal microbiome, genetics and inflammatory status and its impact on the healing of lower gastrointestinal anastomoses

2017

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Gastrointestinal resections are a common operation and most involve an anastomosis to rejoin the ends of the remaining bowel to restore gastrointestinal (GIT) continuity. While most joins heal uneventfully, in up to 26% of patients healing fails and an anastomotic leak (AL) develops. Despite advances in surgical technology and techniques, the rate of anastomotic leaks has not decreased over the last few decades raising the possibility that perhaps we do not yet fully understand the phenomenon of AL and are thus ill‐equipped to prevent it. As in all complex conditions, it is necessary to isolate each different aspect of disease for interrogation of its specific role, but, as we hope to demonstrate in this article, it is a dangerous oversimplification to consider any single aspect as the full answer to the problem. Instead, consideration of important individual observations in parallel could illuminate the way forward towards a possibly simple solution amidst the complexity. This article details three aspects that we believe intertwine, and therefore should be considered together in wound healing within the GIT during postsurgical recovery: the microbiome, the host genetic make‐up and their relationship to the perioperative inflammatory status. Each of these, alone or in combination, has been linked with various states of health and disease, and in combining these three aspects in the case of postoperative recovery from bowel resection, we may be nearer an answer to preventing anastomotic leaks than might have been thought just a few years ago.

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“…The protein responsible was identified as the bacteriocin EntV; this secreted protein demonstrated antihyphal and antivirulence properties without antagonising fungal growth [107•]. Co-infection of these organisms has been shown to attenuate C. albicans virulence in vivo, particularly with an initial administration of E. faecalis [108,109]. Interestingly, this effect was also mimicked in a murine oral candidiasis model, whereby initial administration of heatkilled bacteria was shown to have a protective antifungal effect [110].…”

Section: Endodontic Infections: Sinister Encounters In the Darkmentioning

confidence: 99%

Fungi at the Scene of the Crime: Innocent Bystanders or Accomplices in Oral Infections?

Delaney

Kean

Short

et al. 2018

Curr Clin Micro Rpt

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Purpose of Review Over the last decade, microbiome studies have enhanced our knowledge and understanding of the polymicrobial nature of oral infections. Recently, profiling of the fungal microbiome has expanded our conventional understanding of oral ecology, revealing the critical importance of yeasts within this complex microbiome. This review aims to explore our current appreciation of interkingdom interactions in oral disease. Recent Findings There is a growing evidence base of interactions and pathogenic synergy and antagonism with bacterial species within oral disease. Recent studies have helped to develop our knowledge of how Candida albicans, alongside bacteria such as Porphyromonas gingivalis, Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, and Lactobacillus species, influence overall pathogenicity. Summary Clinical and experimental evidence makes a compelling case for a role for C. albicans in a number of oral infections, though whether its role is an active accomplice or passive bystander remains to be determined.

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Candida albicansandEnterococcus faecalisin the gut

Cited by 50 publications

References 52 publications

Morphological and physiological changes induced by contact-dependent interaction between Candida albicans and Fusobacterium nucleatum

Morphological and physiological changes induced by contact-dependent interaction between Candida albicans and Fusobacterium nucleatum

The triune of intestinal microbiome, genetics and inflammatory status and its impact on the healing of lower gastrointestinal anastomoses

Fungi at the Scene of the Crime: Innocent Bystanders or Accomplices in Oral Infections?

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