Hypericum sampsonii ameliorates radiodermatitis by inhibiting NLRP3 inflammasome activation
Jiayu Liao,
Zhihong Liu,
Sumei Wu
Abstract:BackgroundRadiodermatitis (RD) is an inflammatory lesion of skin mucosa caused by radiation, which causes itching and pain in patients' skin. Hypericum sampsonii has an anti‐inflammatory effect. This study aims to explore the potential effect and mechanism of H. sampsonii on RD.Materials and MethodsThe RD model was established using X‐ray irradiation of mice and the pain response of mice under different treatment methods. Serum levels of IL‐1β, IL‐6, and TNF‐α were measured by ELSA. The RD cell model was const… Show more
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