<i>Hypericum perforatum</i> Extract Against Oxidative Stress, Apoptosis and Oedema in Kidney Induced by Gentamicin

İzol, Volkan; Aridogan, Ibrahim Atilla; Tansug, Zuhtu; Doran, Figen; Erdoğan, Kıvılcım Eren; Kaplan, Halil Mahir; Şingirik, Ergin; Ertuğ, Peyman U.; Pazarcı, Perçin

doi:10.3923/ijp.2019.66.73

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…Gentamicin has been shown to decrease the expression of CAT. Additionally, Izol et al reported that GSH and CAT levels decreased significantly in the gentamicin group but increased significantly when gentamicin was co-administered with Hypericum extract, so this regime keeps the cells safe from free radical injuries (18). Finally, in the present study, SGOT and SGPT levels increased significantly in Cis compared to Cont group.…”

Section: Discussionsupporting

confidence: 61%

“…In addition, the MDA level decreased significantly in the renal tissue in the gentamicin group by Hypericum MDA is a typical marker of lipid peroxidative damage (18). This study showed that Hypericum plant possesses multiple active factors, such as apigenin and hyperforin, which modify apoptosis (18). In the present study, SOD and CAT decreased significantly in the Cis group compared to Cont but increased in the CisH and HCis groups compared to Cis.…”

Section: Discussionsupporting

confidence: 51%

“…In another study, Izol et al showed that gentamicin administration results in edematous injury, which was attenuated by Hypericum extract administration. In addition, the MDA level decreased significantly in the renal tissue in the gentamicin group by Hypericum MDA is a typical marker of lipid peroxidative damage (18). This study showed that Hypericum plant possesses multiple active factors, such as apigenin and hyperforin, which modify apoptosis (18).…”

Section: Discussionmentioning

confidence: 83%

“…This effect shows that decreased glomerular filtration related to ROS leads to increased serum BUN and Cr levels. Hypericum extract prevents ROS production by way of its antioxidant effects and thus leads to decreased BUN and Cr values (18).…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of pretreatment or concomitant treatment with Hypericum extract on renal function and renal toxicity in cisplatin-induced nephrotoxicity

et al. 2022

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Introduction: Cisplatin is a strong anticancer medicine, but its use is limited due to the potential nephrotoxicity induction. Objectives: The present study seeks to determine the impact of Hypericum hydroalcoholic extract on cisplatin-induced nephrotoxicity. Materials and Methods: Thirty-two male rats were assigned to groups 1 to 4. Group 1, control (Cont); treated by saline (IP). Group 2, Cis; cisplatin [intraperitoneal (IP), 7.5 mg/kg]. Group 3, CisH; cisplatin + Hypericum (70 mg/kg, IP, for one week). Group 4, HCis; first treated with Hypericum for a week, followed by cisplatin. Renal tissue and blood samples were obtained a week after cisplatin injection for tissue assay and biochemical analysis. Kidney tissue damage score (KTDS), plasma creatinine (Cr), blood urea nitrogen (BUN), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were measured. Results: Kidney weight showed significant differences between the treated groups and the Cont group (P<0.001). Serum BUN, Cr, SGOT, and SGPT increased significantly in Cont (P<0.01). BUN decreased in CisH and HCis groups compared to Cis group, although there was no significant difference. Serum Cr, SGOT, and SGPT decreased significantly in CisH and HCis groups compared to the Cis group (P<0.05). MDA and KTDS increased in the Cis group and decreased significantly in the CisH and HCis groups compared to the Cis group (P<0.05). Serum SOD and CAT decreased significantly in Cis compared to Cont (P<0.05) and increased in CisH and HCis groups compared to Cis. There was no significant difference between the CisH and HCis groups in any of the measured parameters. Conclusion: This study reveals that pretreatment with Hypericum extract or its concomitant administration with cisplatin can moderate the side-effects of cisplatin, improve renal function and decrease lipid peroxidation, renal toxicity and the KTDS.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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Protective effects of pretreatment or concomitant treatment with Hypericum extract on renal function and renal toxicity in cisplatin-induced nephrotoxicity

et al. 2022

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“…Sümeli et al also reported that the H. perforatum L. extract has anti-inflammatory, anti-fibrotic, and anti-necrotic properties in cases of severe esophageal burns (Sümeli et al, 2022). Izol et al reported that the antioxidant and anti-inflammatory properties of H. perforatum L. extract protecting the kidneys from gentamicin-induced nephrotoxicity (Izol et al, 2019). The anti-inflammatory efficacy of H. perforatum L.…”

Section: Hypericum Scabrum Immersed In Ointmentmentioning

confidence: 99%

The potential role of Hypericum perforatum in wound healing: A literature review on the phytochemicals, pharmacological approaches, and mechanistic perspectives

Farasati Far,

Gouranmohit,

Naimi‐jamal

et al. 2024

Phytotherapy Research

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St. John's Wort, commonly known as Hypericum perforatum L., is a flowering plant in the Clusiaceae family that traditionally been employed for treating anxiety, depression, wounds, burns, sunburn, irritation, and stomach ailments. This review provides a synopsis of H. perforatum L. phytoconstituents and their biological effects, highlighting its beneficial therapeutic properties for dermatological indications, as well as its antioxidant, antimicrobial, anti‐inflammatory, and anti‐angiogenic activity in various applications including wound healing and skin conditions such as eczema, sun burn and minor burns also spastic paralysis, stiff neck and mood disorders as anti‐depressant and nerve pains such as neuralgia. The data were collected from several databases as Web of Science PubMed, ScienceDirect, Scopus and Google Scholar using the terms: “H. perforatum L.”, “H. perforatum L. /phytochemistry,” and “H. perforatum extracts/wound healing” collected from 1994 to 2023. The findings suggest H. perforatum L. acts through various mechanisms and plays a role in each phase of the wound healing process, including re‐epithelialization, angiogenesis, wound contraction, and connective tissue regeneration. H. perforatum L. enhances collagen deposition, decreases inflammation, inhibits fibroblast migration, and promotes epithelialization by increasing the number of fibroblasts with polygonal shape and the number of collagen fibers within fibroblasts. H. Perforatum L. extracts modulate the immune response and reduce inflammation were found to accelerate the wound healing process via inhibition of inflammatory mediators' production like interleukin‐6, tumor necrosis factor‐α, cyclooxygenase‐2 gene expression, and inducible nitric oxide synthase. Thus, H. perforatum L. represents a potential remedy for a wide range of dermatological problems, owing to its constituents with beneficial therapeutic properties. H. perforatum L. could be utilized in the development of novel wound healing therapies.

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Efficiency of hypericum perforatum, povidone iodine, tincture benzoin and tretinoin on wound healing

Yalçınkaya

Başaran

Tunckasık

et al. 2022

Food and Chemical Toxicology

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Hypericum perforatum Extract Against Oxidative Stress, Apoptosis and Oedema in Kidney Induced by Gentamicin

Cited by 9 publications

References 28 publications

Protective effects of pretreatment or concomitant treatment with Hypericum extract on renal function and renal toxicity in cisplatin-induced nephrotoxicity

Protective effects of pretreatment or concomitant treatment with Hypericum extract on renal function and renal toxicity in cisplatin-induced nephrotoxicity

The potential role of Hypericum perforatum in wound healing: A literature review on the phytochemicals, pharmacological approaches, and mechanistic perspectives

Efficiency of hypericum perforatum, povidone iodine, tincture benzoin and tretinoin on wound healing

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