<i>Hymenolepis microstoma</i>: direct life cycle in immunodeficient mice

Andreassen, J.; Ito, Akira; Ito, Mamoru; Nakao, Minoru; Nakaya, Kazuhiro

doi:10.1079/joh2003207

Cited by 22 publications

(18 citation statements)

References 11 publications

(16 reference statements)

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“…However, the absence of Asp. tetraptera in some of these sites (THL, NDB) may explain why this nematode is less prevalent at the (Andreassen et al 2004) that are a priori widely distributed in Senegal (Sembène et al 2008).…”

Section: Evidence For Enemy Lossmentioning

confidence: 99%

Parasites and invasions: changes in gastrointestinal helminth assemblages in invasive and native rodents in Senegal

Diagne

Ribas

Charbonnel

et al. 2016

International Journal for Parasitology

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Understanding why some exotic species become widespread and abundant in their colonised range is a fundamental issue that still needs to be addressed. Among many hypotheses, newly established host populations may benefit from a parasite loss ("enemy release" hypothesis) through impoverishment of their original parasite communities or reduced infection levels. Moreover, the fitness of competing native hosts may be negatively affected by the acquisition of exotic taxa from invaders ("parasite spillover") and/or by an increased transmission risk of native parasites due to their amplification by invaders ("parasite spillback"). We focused on gastrointestinal helminth communities to determine whether these predictions could explain the ongoing invasion success of the commensal house mouse (Mus musculus domesticus) and black rat (Rattus rattus), as well as the associated decrease in native Mastomys spp., in Senegal. For both invasive species, our results were consistent with the predictions of the enemy release hypothesis. A decrease in overall gastrointestinal helminth prevalence and infracommunity species richness was observed along the invasion gradients as well as lower specific prevalence/abundance (Aspiculuris tetraptera in Mus musculus domesticus, Hymenolepis diminuta in Rattus rattus) on the invasion fronts. Conversely, we did not find strong evidence of GIH spillover or spillback in invasion fronts, where native and invasive rodents co-occurred. Further experimental research is needed to determine whether and how the loss of gastrointestinal helminths and reduced infection levels along invasion routes may result in any advantageous effects on invader fitness and competitive advantage.

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Section: Evidence For Enemy Lossmentioning

confidence: 99%

Parasites and invasions: changes in gastrointestinal helminth assemblages in invasive and native rodents in Senegal

Diagne

Ribas

Charbonnel

et al. 2016

International Journal for Parasitology

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“…Only through use of flour beetles as intermediate hosts have any healthy rodents been artificially infected with H. microstoma (Nasher and Walkey 1981). Andreassen et al (2004) have demonstrated that H. microstoma can develop into an adult without an intermediate host in artificially immunodeficient mice when a cestode egg is injected or ingested through coprophagy. This suggests the possibility of a direct lifecycle of H. microstoma in immunodeficient mice and lends support to the idea that H. microstoma could be phylogenetically closely related to H. nana, which is the only tapeworm known to not require an intermediate host in order to develop into an adult (Cuomo et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Protecting Free-Living Dormice: Molecular Identification of Cestode Parasites in Captive Dormice (Muscardinus avellanarius) Destined for Reintroduction

et al. 2016

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The success of any population translocation programme relies heavily on the measures implemented to control and monitor the spread of disease. Without these measures, programmes run the risk of releasing immunologically naïve species or, more dangerously, introducing novel infectious agents to native populations. As a precaution, a reintroduction programme for the common or hazel dormouse, Muscardinus avellanarius, in England screens dormice before release following captive breeding. Using PCR sequencing of a range of genes, we tested whether the same species of tapeworm(s) were present in captive and free-living dormice. Whilst only Rodentolepis straminea were identified in free-living dormice, cestode ova found in a captive individual produced a molecular match closely related to Hymenolepis microstoma and a previously unrecorded Rodentolepis species. To prevent putting at risk the free-living population, we recommended the continued treatment of dormice showing tapeworm infection before release. Our work demonstrates how molecular techniques can be used to inform reintroduction programmes, reduce risk from disease and increase chances of reintroduction success.

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“…However, in congenitally athymic mice, Andreassen et al . [27] found that autoinfection was possible, showing that oncospheres penetrated the intestinal tissues and developed into cysticeroids that subsequently excysted and developed normally in the bile duct and duodenum, in a manner similar to the direct cycle of H. nana . Autoinfection of BALB/c mice was also implied by the detection of stage-specific antigens [28].…”

Section: Discussionmentioning

confidence: 99%

Description of Hymenolepis microstoma (Nottingham strain): a classical tapeworm model for research in the genomic era

Cunningham

Olson

2010

Parasites Vectors

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BackgroundHymenolepis microstoma (Dujardin, 1845) Blanchard, 1891, the mouse bile duct tapeworm, is a rodent/beetle-hosted laboratory model that has been used in research and teaching since its domestication in the 1950s. Recent characterization of its genome has prompted us to describe the specific strain that underpins these data, anchoring its identity and bringing the 150+ year-old original description up-to-date.ResultsMorphometric and ultrastructural analyses were carried out on laboratory-reared specimens of the 'Nottingham' strain of Hymenolepis microstoma used for genome characterization. A contemporary description of the species is provided including detailed illustration of adult anatomy and elucidation of its taxonomy and the history of the specific laboratory isolate.ConclusionsOur work acts to anchor the specific strain from which the H. microstoma genome has been characterized and provides an anatomical reference for researchers needing to employ a model tapeworm system that enables easy access to all stages of the life cycle. We review its classification, life history and development, and briefly discuss the genome and other model systems being employed at the beginning of a genomic era in cestodology.

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Hymenolepis microstoma: direct life cycle in immunodeficient mice

Cited by 22 publications

References 11 publications

Parasites and invasions: changes in gastrointestinal helminth assemblages in invasive and native rodents in Senegal

Parasites and invasions: changes in gastrointestinal helminth assemblages in invasive and native rodents in Senegal

Protecting Free-Living Dormice: Molecular Identification of Cestode Parasites in Captive Dormice (Muscardinus avellanarius) Destined for Reintroduction

Description of Hymenolepis microstoma (Nottingham strain): a classical tapeworm model for research in the genomic era

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