<i>Humulus japonicus</i>Extracts Protect Against Lipopolysaccharide/<scp>d</scp>-Galactosamine-Induced Acute Liver Injury in Rats

Bae, Jinhyung; Min, Young; Nam, Yoonjin; Lee, Hyun Seok; Sohn, Uy Dong

doi:10.1089/jmf.2018.4178

Cited by 17 publications

(10 citation statements)

References 33 publications

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“…The serum levels of ALT and AST are sensitive markers for measuring liver injury (10,29). To investigate the effect of H 2 S on liver function, the serum levels of ALT, AST and ammonia were measured.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure

Yuan

Huang

et al. 2020

Exp Ther Med

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Acute liver failure (ALF) is a devastating clinical syndrome with a high mortality rate if not treated promptly. Previous studies have demonstrated the beneficial effects of hydrogen sulfide (H 2 S) on the brain and liver. The present study aimed to investigate the potential protective effects of H 2 S in ALF. A mouse model of ALF was established following treatment with thioacetamide (TAA). Mice with TAA-induced ALF were intraperitoneally injected with 30 or 100 µmol/kg/day sodium hydrosulfide (NaHS; a H 2 S donor drug) for two weeks. According to results from novel object recognition and Y-maze tests, in the present study, NaHS treatment alleviated cognitive deficiency and preserved spatial orientation learning ability in TAA-induced ALF mice compared with those of untreated mice. In addition, NaHS treatment reduced serum levels of aspartate transaminase (AST), alanine transaminase (ALT) and the concentration of ammonia compared with those that received control treatment, resulting in weight loss prevention. These findings suggested a beneficial effect of H 2 S on liver function. In conclusion, results from the present study suggested that H 2 S treatment may alleviate cognitive deficiency and hepatic dysfunction in mice with ALF, indicating the potential therapeutic benefits of applying H 2 S for the treatment of ALF.

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Section: Discussionmentioning

confidence: 99%

Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure

Yuan

Huang

et al. 2020

Exp Ther Med

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“…Pathogenesis of ALI may be related to drugs, toxins, alcohol, metabolic diseases or chronic autoimmune hepatitis (Shi et al 2018;Wang, Diao et al 2018). At present, the clinical prognosis for ALI is not good, as this condition usually occurs unpredictably and deteriorates rapidly (Bae et al 2018). Hence, for ALI, prevention is as important as an effective treatment.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl₄-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling

Zhang

Feng

et al. 2020

Pharmaceutical Biology

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Context: Camellia nitidissima Chi (Theaceae) is an evergreen shrub, the leaves of which are used in many medicinal applications. Objective: To characterize the chemical composition of a 10% aqueous ethanol extract of C. nitidissima leaves (CNE), and to explore the protective effect of the extract against acute liver injury (ALI) in rats. Materials and methods: Male Sprague-Dawley rats were divided into six groups (n ¼ 10): control and negative (0.5% CMC-Na, 5 mL/kg/d), thiopronin (20 mg/kg/d) and CNE (40, 80 and 160 mg/kg/d). All groups were treated for seven consecutive days, and then, except for the control, carbon tetrachloride was administered intraperitoneally. The biochemical parameters, mRNAs, and proteins were analyzed using enzyme-linked immunoassays kits, quantitative polymerase chain reaction and western blot. Chemical components were identified using mass spectroscopy, and the phenol and flavonoid content determined by ultraviolet spectrophotometry. Results: Pre-treatment with CNE (160 mg/kg) attenuated the pathological changes in liver tissues and decreased alanine transaminase (62 and 60%), aspartate transaminase (49 and 53%) and malondialdehyde (35 and 42%) levels in serum and liver tissues. Moreover, CNE reduced the concentrations of reactive oxygen species (55%), tumour necrosis factor-a (26%), interleukin-1b (19%) and IL-6 (19%) and blocked the nuclear translocation of p65. Pre-treatment with CNE increased anti-heme oxygenase-1 (40%), superoxide dismutase (108%) and glutathione (97%) levels through upregulating nuclear factor erythroid-2-related factor 2. Twelve compounds were detected; the content of phenols and flavonoids was determined as 34.474 ± 1.026 and 15.228 ± 0.422 mg/g crude drug in CNE, respectively. Discussion and conclusions: These results suggested that CNE is a promising agent for functional food and hepatoprotective drug against ALI.

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“…Determination of the enzymes activities was performed according to the standard methods using kits purchased from Spinreact (Girona, Spain) and BioVision (Milpitas, CA, USA). 3,23 The malondialdehyde (MDA) contents were measured in the heart homogenate (10% w/v in 10mM ice-cold Tris-HCl buffer (pH 7.4)) according to the method of Ohkawaet al 24 Reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were determined according to the methods of Beutleret al, 25 Nishikimiet al 26 and Aebi, 27 respectively. The protein content in the heart homogenate was assayed according to the previously described method of Lowry et al 28…”

Section: Biochemical Assaymentioning

confidence: 99%

Artemisia judaica Attenuates Hyperglycaemia-Mediated Oxidative Stress and Cardiac Injury in Streptozotocin-Induced Diabetic Rats

2020

TJNPR

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Diabetes mellitus (DM) is a metabolic disorder characterised by hyperglycaemia and associated with numerous acute and chronic complications such as nephropathy, retinopathy and cardiomyopathy. Diabetic cardiomyopathy (DCM) as one of the common long-term diabetic consequences involves various pathological changes in the myocardium that eventually lead to heart failure. 1,2 Hyperglycaemia-mediated oxidative stress plays a crucial role in the pathophysiological mechanisms underlying myocardial damage in diabetic cardiomyopathy. 2,3 Excess reactive oxygen species (ROS) stimulate the inflammatory process and apoptotic death pathways activation eventually culminating in myocardial damage and development of DCM. 3-5 Therefore, scavenging of ROS by antioxidants has gained much attention as a promising approach to attenuate DCM and other diabetes complications which are mediated by oxidative damage. Artemisia judaica L. (A. judaica) belongs to the family Asteraceae and Artemisia genera which are widely used in folk medicine being recommended by Bedouins in Middle Eastern countries where it is known by the Arabic name "Al-ba'atharan". 6 Traditionally, it is widely used for the treatment of gastro-intestinal disorders, heart diseases, erectile dysfunction, diabetes mellitus, wound healing, and inflammatory related diseases such as arthritis. 7 Extracts and isolated compounds from A. judaica have exhibited various biological and

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Humulus japonicusExtracts Protect Against Lipopolysaccharide/d-Galactosamine-Induced Acute Liver Injury in Rats

Cited by 17 publications

References 33 publications

Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure

Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure

Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl₄-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling

Artemisia judaica Attenuates Hyperglycaemia-Mediated Oxidative Stress and Cardiac Injury in Streptozotocin-Induced Diabetic Rats

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Humulus japonicusExtracts Protect Against Lipopolysaccharide/d-Galactosamine-Induced Acute Liver Injury in Rats

Cited by 17 publications

References 33 publications

Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure

Hydrogen sulfide alleviates cognitive deficiency and hepatic dysfunction in a mouse model of acute liver failure

Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl4-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling

Artemisia judaica Attenuates Hyperglycaemia-Mediated Oxidative Stress and Cardiac Injury in Streptozotocin-Induced Diabetic Rats

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Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl₄-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling