hsdS
A
regulated extracellular vesicle-associated PLY to protect
Streptococcus pneumoniae
from macrophage killing via LAPosomes
Liping Wang,
Mengyuan Liu,
Yixin Qi
et al.
Abstract:Streptococcus pneumoniae
is a notorious human opportunistic pathogen which undergoes a spontaneous and reversible phenotypic change in response to the host environment. We demonstrated that the regulatory gene
hsdS
A
of DNA methylation in the type I restriction modification system altered colony transparency and substantially contributed to
S. pneumoniae
virulence. Most importantly,
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