HOGG1 Ser³²⁶Cys polymorphism and modification by environmental factors of stomach cancer risk in Chinese

Abstract

Oxidative stress is involved in many types of DNA damage, e.g., resulting in 8-hydroxyguanine adducts. Since a human counterpart exists for the yeast gene OGG1 (hOGG1) encoding an enzyme that repairs 8-hydroxyguanine, its polymorphism, Ser 326 Cys, might have potential as a genetic marker for cancer susceptibility. To investigate its association with stomach cancer risk and possible interactions with environmental factors, we conducted a case-control study of 101 stomach cancer cases and 198 controls using PCR-singlestrand conformation polymorphism and a questionnaire approach. The proportional distribution of the Cys/Cys alleles did not differ between stomach cancer cases and controls, but subgroup analyses revealed that a frequent drinking habit elevated the odds ratio (OR) for stomach cancer in Cys/Cys compared to Ser/Ser and Ser/Cys carriers. The ORs with frequent consumption of pickled vegetables and meat tended to be higher in Cys/Cys than in Ser/Ser and Ser/Cys carriers, these interactions being on the borderline of statistical significance. Our findings suggest that the hOGG1 Ser 326 Cys polymorphism may alter the impact of some environmental factors on stomach cancer development. For confirmation, an additional study with a larger number of subjects is now required.

Lack of Association between the hOGG1 Ser326Cys Polymorphism and Gastric Cancer Risk: a Meta-analysis

“…Controls were mainly healthy populations, and matched with age or cancer-free. Genotype distributions in the controls of all studies were in agreement with HWE except one (Takezaki et al, 2002). …”

“…Of these studies, three (Poplawski et al, 2006;Arai et al, 2008;Li et al, 2009) were excluded because these studies didn't report available data. As a result, a total of eleven publications Hanaoka et al, 2001;Takezaki et al, 2002;Tsukino et al, 2004;Capella et al, 2008;Farinati et al, 2008;Canbay et al, 2010;Malik et al, 2010;Palli et al, 2010;Sun et al, 2010;Engin et al, 2011) involving 5,107 subjects were included in this meta-analysis. Table 1 lists the main characteristics of these studies.…”

“…Oxidative DNA damage caused by ROS is thought to be one of the pathogeneses (Farinati et al, 1998), and thus hOGG1 Ser326Cys polymorphism, responsible for repairing ROS generating DNA damage, may associate to susceptibility to GC. However, published studies conducted to observe the relations showed inconsistent results, including lack of association Hanaoka et al, 2001;Poplawski et al, 2006;Arai et al, 2008;Capella et al, 2008;Malik et al, 2010;Palli et al, 2010;Sun et al, 2010;Engin et al, 2011) and positive association interacting with other factors (Takezaki et al, 2002;Tsukino et al, 2004;Farinati et al, 2008;Li et al, 2009). In order to decisively conclude, a meta-analysis was performed to evaluate the association between hOGG1 Ser326Cys polymorphism and the susceptibility of GC.…”

Genetic polymorphism of hOGG1 and risk of pterygium in Chinese

“…[24][25][26][27] In order not to interfere with our analysis of hOGG1 polymorphism on the susceptibility to the pterygium, the subjects suffering from benign or malignant tumours were excluded. On the other hand, owing to the fact that the veterans accounted for approximately 50% of our patients, there were higher proportions of male sex and outdoor occupation type in our patients and controls.…”

“…The hOGG1 Cys/Cys homozygosity has been reported to increase the risks of lung cancer, 24 oesophageal cancer, 25 orolaryngeal cancer, 26 and stomach cancer. 27 Additionally, some studies revealed the impact of this genetic polymorphism on patients suffering from chronic oxidative stress. 28,29 In this study, we tried to investigate whether the hOGG1 genetic polymorphism is associated with the susceptibility of humans to pterygium.…”