<i>HLA</i> class I alleles are associated with clinic-based migraine and increased risks of chronic migraine and medication overuse

Huang, Claire; Chen, Wei–Ta; Huang, Yuhan; Chen, Hsuan‐Yu; Lee, Hsuan-Shu; Wang, Shuu Jiun

doi:10.1177/0333102420902228

Cited by 12 publications

(15 citation statements)

References 43 publications

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“…A case–control study carried out by Huang et al . in 2020, including a large cohort of 2999 cases and 6055 controls, sought to overcome these limitations, by using a high-resolution technique [ 30 ]. In this study, a significant association between HLA -B and C and clinic-based migraine was reported.…”

Section: Genetic Findings Related To the Immune System In Migraineursmentioning

confidence: 99%

Immunological findings in patients with migraine and other primary headaches: a narrative review

Biscetti

Vanna

Cresta

et al. 2021

Clinical and Experimental Immunology

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Experimental findings suggest an involvement of neuroinflammatory mechanisms in the pathophysiology of migraine. Specifically, preclinical models of migraine have emphasized the role of neuroinflammation following the activation of the trigeminal pathway at several peripheral and central sites including dural vessels, the trigeminal ganglion and the trigeminal nucleus caudalis. The evidence of an induction of inflammatory events in migraine pathophysiological mechanisms has prompted researchers to investigate the Human leukocyte antigen (HLA) phenotypes as well as cytokine genetic polymorphisms in order to verify their potential relationship with migraine risk and severity. Furthermore, the role of neuroinflammation in migraine seems to be supported by evidence of an increase in pro-inflammatory cytokines, both ictally and interictally, together with the prevalence of Th1 lymphocytes and a reduction in regulatory lymphocyte subsets in peripheral blood of migraineurs. Cytokine profiles of cluster headache patients and those of tension-type headache patients further suggest an immunological dysregulation in the pathophysiology of these primary headaches, although evidence is weaker than for migraine. The present review summarizes available findings to date from genetic and biomarker studies that have explored the role of inflammation in primary headaches.

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Section: Genetic Findings Related To the Immune System In Migraineursmentioning

confidence: 99%

Immunological findings in patients with migraine and other primary headaches: a narrative review

Biscetti

Vanna

Cresta

et al. 2021

Clinical and Experimental Immunology

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“…Second, previously identified SNPs significant for clinic-based migraine patients in Taiwan were not replicated in this study. This might imply that the genetic constituents for headaches in community-based cases are different from migraine in clinic-based cases, which could be supported by our previous study showing that HLA class I variants contribute only to clinic-based migraine patients but not community-based migraine patients (9). Third, our sample size is relatively smaller.…”

Section: Discussionmentioning

confidence: 67%

“…The results from these studies inferred that while there is a shared genetic basis across ethnicities, some genetic variants contributing to the complex pathogenesis of migraine might be specific to selected populations (8). In addition, we also identified that the genetic constituents of migraine in the clinic-based cohort were distinct from those in the community-based cohort (9).…”

Section: Introductionmentioning

confidence: 90%

“…In contrast, GWASs for headache disorders from Asian populations are scarce. To date, only two GWASs in Asian migraine patients, both conducted in Taiwan, have been published (8,9). The results from these studies inferred that while there is a shared genetic basis across ethnicities, some genetic variants contributing to the complex pathogenesis of migraine might be specific to selected populations (8).…”

Section: Introductionmentioning

confidence: 99%

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Genome-wide association study reveals susceptibility loci for self-reported headache in a large community-based Asian population

et al. 2021

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Background The genetic substrate for headache in the general population has not been identified in Asians. We investigated susceptible genetic variants for self-reported headache in a large community-based Asian population. Methods We conducted a genome-wide association study in participants recruited from a community-based cohort to identify the genetic variants associated with headache in Taiwanese. All participants received a structured questionnaire for self-reported headache. A total of 2084 patients with “self-reported headache” and 11,822 age- and sex-matched controls were enrolled. Gene enrichment analysis using the Genotype-Tissue Expression version 6 database was performed to explore the potential function of the identified variants. Results We identified two novel loci, rs10493859 in TGFBR3 and rs13312779 in FGF23, that are functionally relevant to vascular function and migraine to be significantly associated with self-reported headache after adjusting age, sex and top 10 principal components ( p = 8.53 × 10−11 and p = 1.07 × 10−8, respectively). Gene enrichment analysis for genes with GWAS suggestive significance ( p < 10−6) demonstrated that the expression of these genes was significantly enriched in the artery ( p = 8.18 × 10−4) and adipose tissue ( p = 8.95 × 10−4). Conclusion Our results suggest that vascular dysfunction might play important roles in the pathogenesis of self-reported headache in Asian populations.

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“…Some environmental factors such as medication-overuse are known, but a genetic disposition is also an obvious possibility. There have been attempts to find genetic risk factors for CM [11][12][13][14][15][16][17] These studies have, however, used a candidate-gene approach comparing CM with healthy controls and not with EM. No studies have to date investigated whether a genetic component promotes the development of EM into CM.…”

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confidence: 99%

Chronic migraine: Genetics or environment?

Chalmer

Rasmussen

Kogelman

et al. 2021

Euro J of Neurology

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Background The transition from episodic migraine to chronic migraine, migraine chronification, is usually a gradual process, which involves multiple risk factors. To date, studies of the genetic risk factors for chronic migraine have focused primarily on candidate‐gene approaches using healthy individuals as controls. Aims and methods In this study, we used a large cohort of migraine families and unrelated migraine patients (n > 2200) with supporting genotype and whole‐genome sequencing data. We evaluated whether there are any genetic variants, common or rare, with a specific association to chronic migraine compared with episodic migraine. Results We found no aggregation of chronic migraine in families with a clustering of migraine. No specific rare variants gave rise to migraine chronification, and migraine chronification was not associated with a higher polygenic risk score. Migraine chronification was not associated with allelic associations with an odds ratio above 2.65. Assessment of effect sizes with genome‐wide significance below an odds ratio of 2.65 requires a genome‐wide association study of at least 7500 chronic migraine patients. Conclusion Our results suggest that migraine chronification is caused by environmental factors rather than genetic factors.

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HLA class I alleles are associated with clinic-based migraine and increased risks of chronic migraine and medication overuse

Cited by 12 publications

References 43 publications

Immunological findings in patients with migraine and other primary headaches: a narrative review

Immunological findings in patients with migraine and other primary headaches: a narrative review

Genome-wide association study reveals susceptibility loci for self-reported headache in a large community-based Asian population

Chronic migraine: Genetics or environment?

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