<i>HLA‐DRB1*09:01</i> allele is associated with anti‐E immunization in a Chinese population

Tian, Lei; Li, Hou; Wang, Lixin; Xu, Hongtao; Xiao, Jie; Ying, Binwu

doi:10.1111/trf.14568

Cited by 12 publications

(5 citation statements)

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“…Schonewille and colleagues proposed that some recipient HLAs such as HLA‐DRB1*15 may be markers of hyperresponders. In addition, a current study by Tian and colleagues revealed that HLA‐DRB1*09:01 is associated with anti‐E immunization. In this regard, a future study of nonresponsiveness may be as useful as understanding responsiveness.…”

Section: Discussionmentioning

confidence: 67%

The prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen‐matched red blood cells for thalassemia transfusions: a 10‐year experience at a tertiary care hospital

et al. 2018

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The prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen-matched red blood cells for thalassemia transfusions: a 10-year experience at a tertiary care hospital BACKGROUND: Hemoglobin E-β 0 thalassemia and homozygous β 0 -thalassemia are the most common chronic transfusion-dependent thalassemias in Thailand. Patients with these conditions can experience clinical complications such as RBC alloimmunization. In this study we aimed to determine the prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen-(C, c, E, e, Mi a ) matched RBC transfusion. STUDY DESIGN AND METHODS: Thalassemia patients were recruited from a tertiary care hospital for 10 years from 2008 to 2017. The medical records of transfusion history were reviewed for red cell phenotype both of patients and donors, number of units transfused, and type of alloantibodies. RESULTS: A total of 383 thalassemia patients were identified (178 males and 205 females). The frequency of RBC alloantibodies was 19.3%. Some patients tested positive for more than one antibody type. Autoantibodies were detected in nine individuals. Anti-E (49 [39.5%]), anti-Mi a (24 [19.4%]), and anti-c (19 [15.3%]) were the most common antibodies detected. A high rate of alloimmunization was found in splenectomized patients. Risk of alloimmunization increased when more total units of blood had been transfused. A trend toward low alloimmunization rates was noted in the antigen-matched RBC group, where 3.5% (5/143) of patients were alloimmunized. Anti-E and anti-Mi a , which may be naturally occurring, were identified in this group.CONCLUSION: Thai patients are more prone to develop antibodies against the Rh and Mi a than to the Kell blood group antigens.

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Section: Discussionmentioning

confidence: 67%

The prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen‐matched red blood cells for thalassemia transfusions: a 10‐year experience at a tertiary care hospital

et al. 2018

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“…ABO, Rh, Kell, Kidd, Duffy, MNS, P, Lewis and Lutheran are the major blood group systems (Daniels, ; Smart & Armstrong, ). Alloantibodies against Rh (E, c), MNS (Mi a ) and Kidd (Jk a ) blood groups are the most commonly reported in Asian populations (Cheng, Lee, & Lin, ; Romphruk et al, ; Tian et al, ). Moreover, these antibodies have frequently been identified as a cause of haemolytic transfusion reactions and HDFN in a range of studies (Chatziantoniou et al, ; Michalewska, Ejduk, & Pniewska, ).…”

Section: Introductionmentioning

confidence: 99%

Phenotype frequencies of Rh (C, c, E, e), M, Mi^a and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand

Romphruk

Butryojantho

Jirasakonpat

et al. 2019

Int J Immunogenetics

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We here report the first study of antigen and phenotype frequencies of Rh (C, c, E, e), M, Mia and Kidd antigens in north‐east Thai blood donors. Blood transfusion services aim to ensure availability of adequate and safe blood to minimize the development of transfusion reactions. For pre‐transfusion testing, the most important blood group systems are ABO and RhD. The transfusion of ABO‐compatible otherwise unknown phenotype blood may result in alloimmunization, especially in multi‐transfused patients. Extended red blood cell (RBC) phenotyping and selection of blood negative for specific antigens reduce post‐transfusion complications and allow for effective blood transfusion regimens to be achieved. A total of 13,567 regular repeated, voluntary Thai blood donors were included for red‐cell antigen typing of Rh (D, C, E, c, e). Samples from 12,768, 9,389 and 13,059 donors were typed for Kidd, M and Mia antigens, respectively. Amongst Rh antigens, e was the most common (96.80%) followed by C (95.50%), c (34.40%) and E (32.20%) with CCDee (60.00%) being the most common phenotype. For Kidd phenotypes, Jk(a+b+) was the most common (46.73%) and Jk(a−b−) was rare (0.07%). For the M and Mia antigen, M(+) was most frequently found (94.96%) and Mia(+) was found in 17.97% of individuals. Knowledge of red‐cell antigen phenotype frequencies in a population is helpful for creating a phenotype database of blood donors which can provide antigen‐negative compatible blood to patients with multiple alloantibodies. Moreover, provision of antigen‐matched blood can prevent alloimmunization in multi‐transfused patients.

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“…Moreover, Asian alloantibodies against Rh (E, c) blood groups are the most commonly reported antibodies. 10,11 Therefore, feto-maternal Rh incompatibility still represents the major cause of HDFN.7, 12 ABO distribution analysis in this study demonstrated that 'B' is the most common blood group, followed by O, A and AB, respectively. This finding is in complete agreement with the research conducted by Mahmood et al in the year 2016.…”

Section: Discussionmentioning

confidence: 64%

Genotypic Frequency of RHC Antigen in Women of Reproductive Age in Pakistan

Bashir

Akhtar²,

Naeem³

et al. 2022

PAFMJ

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Objective: To determine the genotypic frequency of RHC antigen in females of reproductive age. Study Design: Cross-sectional study. Place and Duration of Study: Armed Forces Institute of Transfusion (AFIT) and Pak Emirates Military Hospital, (PEMH) in collaboration with NUMS Pakistan, from Dec 2020 to Dec 2021. Methodology: Females aged 16 to 45 years were recruited in the study. Demographic data, including age, parity, ethnicity etc.,was recorded on a proforma. Venous blood samples were collected in EDTA tubes, and DNA was extracted using 5% Chelex TM. A conventional Polymerase chain reaction and amplified products were subjected to Polyacrylamide Gel electrophoresis. Results: Amongst 200 females, 172(86%) had the expression of RHC antigen, while 28(14%) were negative for the respective antigen. These results were valuable in predicting the risk of hemolytic disease in fetuses and newborns and alloimmunization in our population. Conclusion: Females in the reproductive age group had RHC positivity of 86%. This data will help predict the risk of HDFN in future pregnancies and individuals at risk of alloimmunization in RHC-negative women.

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HLA‐DRB109:01* allele is associated with anti‐E immunization in a Chinese population

Cited by 12 publications

References 20 publications

The prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen‐matched red blood cells for thalassemia transfusions: a 10‐year experience at a tertiary care hospital

The prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen‐matched red blood cells for thalassemia transfusions: a 10‐year experience at a tertiary care hospital

Phenotype frequencies of Rh (C, c, E, e), M, Mi^a and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand

Genotypic Frequency of RHC Antigen in Women of Reproductive Age in Pakistan

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HLA‐DRB1*09:01 allele is associated with anti‐E immunization in a Chinese population

Cited by 12 publications

References 20 publications

The prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen‐matched red blood cells for thalassemia transfusions: a 10‐year experience at a tertiary care hospital

The prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen‐matched red blood cells for thalassemia transfusions: a 10‐year experience at a tertiary care hospital

Phenotype frequencies of Rh (C, c, E, e), M, Mia and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand

Genotypic Frequency of RHC Antigen in Women of Reproductive Age in Pakistan

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HLA‐DRB109:01* allele is associated with anti‐E immunization in a Chinese population

Phenotype frequencies of Rh (C, c, E, e), M, Mi^a and Kidd blood group systems among ethnic Thai blood donors from the north‐east of Thailand